Información de la revista
Vol. 114. Núm. 3.
Páginas T282-T284 (Marzo 2023)
Descargar PDF
Más opciones de artículo
Vol. 114. Núm. 3.
Páginas T282-T284 (Marzo 2023)
Case and Research Letter
Open Access
[Translated article] Evaluation of Dermatology Life Quality Index (DLQI) Scores in Patients With Psoriasis: A Cross-sectional and Correlation Study Over a 6-Year Period
Evaluación de los resultados del Índice de Calidad de Vida en Dermatología (DLQI) en pacientes con diagnóstico de psoriasis: un estudio transversal y de correlación durante un periodo de 6 años
P.M. Guavita Fallaa,b,
Autor para correspondencia

Corresponding author.
, J.R. Castro Ayarzaa,c, C. Cortés Correaa,b,c, E. Peñaranda Contrerasa,b,c
a Programa de Dermatología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia
b Servicio de Dermatología, Hospital Universitario de La Samaritana, Bogotá, Colombia
c Grupo Colombiano de Psoriasis e Inmunodermatología – COLPSOR
Contenido relaccionado
P.M. Guavita Falla, J.R. Castro Ayarza, C. Cortés Correa, E. Peñaranda Contreras
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Descargar PDF
Texto completo
To the Editor,

Psoriasis is a chronic inflammatory skin disease that affects patient quality of life and social and emotional well-being.1 Its effects can be evaluated using several questionnaires, including the widely used Dermatology Life Quality Index (DLQI).2 The aims of this study were to assess quality of life in a series of patients with psoriasis, examine which aspects of their lives were most affected, and examine correlations with other clinical measures, comorbidities, and treatment.

We performed a retrospective, cross-sectional, correlational study of patients older than 18 years with a diagnosis of psoriasis who were treated at Hospital Universitario de La Samaritana and a private dermatology clinic in Bogotá, Colombia, between 2010 and 2016. Data were collected by reviewing medical records. A total of 163 patients, selected by non-probabilistic convenience sampling, were included. Patient characteristics and clinical features, scores, and measures are summarized in Tables 1 and 2. DLQI scores according to sex and special psoriasis location are summarized, together with the results of the bivariate analysis, in Table 3. The data were analyzed in SPSS version 24.

Table 1.

Demographic and Clinical Characteristics of the Study Population (n=163).

Variable  Result 
Age, mean (SD), y  48.7 (14)a 
Male sex, No. (%)  112 (68.7) 
Type of psoriasis, No. (%)
Vulgaris (plaque)  147 (90.2) 
Guttata  10 (6.2) 
Pustular  3 (1.8) 
Erythrodermic  2 (1.2) 
Not defined  1 (0.6) 
Psoriasis in special locations, No. (%)
Scalp  59 (36.2) 
Genital area  22 (13.5) 
Palms/soles  7 (4.3) 
Nails associated with other types of psoriasis  35 (21.5) 
Comorbidities, No. (%)
Hypertension  37 (22.7) 
Dyslipidemia  48 (29.4) 
Diabetes mellitus  15 (9.2) 
Rheumatoid arthritis  3 (1.8) 
Hypothyroidism  14 (8.6) 
Psoriatic arthritis  10 (6.1) 
Topical treatment, No. (%)  76 (46.6) 
Corticosteroids only  50 (30.6) 
Corticosteroids+salicylic acid  15 (9.2) 
Calcipotriol+betamethasone  10 (6.1) 
Calcipotriol  1 (0.6) 
Nonbiologic systemic treatment, No. (%)  34 (20.9) 
Methotrexate  26 (16) 
Cyclosporine  3 (1.8) 
Acitretin  1 (0.6) 
Phototherapy  4 (2.5) 
Biologic therapy, No. (%)  11 (6.7) 
Etanercept  3 (1.8) 
Adalimumab  4 (2.4) 
Infliximab  2 (1.2) 
Secukinumab  1 (0.6) 
Ustekinumab  1 (0.6) 

K–S statistic (P=.2).

Table 2.

DLQI, PASI, and BSA Values for Study Population.

Variable  Result 
BSA score, median (IQR)  5 (11)a 
BSA10%, No. (%)  107 (65.6) 
PASI score, median (IQR)  5.1 (7.4)a 
PASI categories, No. (%)
<5  79 (48.4) 
5–10  44 (27) 
>10  40 (24.6) 
Total DLQI score, median (IQR)  8 (12)a 
Impact on quality of life, No. (%)  140 (85.9) 
DLQI categories, No. (%)
No effect on patient quality of life (0–1)  23 (14.1) 
Small effect on patient quality of life (2–5)  37 (22.7) 
Moderate effect on patient quality of life (6–10)  36 (22.1) 
Very large effect on patient quality of life (11–20)  50 (30.7) 
Extremely large effect on patient quality of life (21–30)  17 (10.4) 

Abbreviations: BSA, body surface area; DLQI, Dermatology Life Quality Index; PASI, Psoriasis Area and Severity Index; IQR, interquartile range.


K–S statistic (P=.000).

Table 3.

DLQI Scores According to Sex and Special Psoriasis Location and Results of Bivariate Analysis.

Variable  DLQI score by variable
Sex, median (IQR)
Male  8 (12)a
Female  8 (14)a
Psoriasis in special location, mean (95% CI)
Scalp  13.4 (11.4–15.3)
Genital area  17.8 (15.3–20.2)
Palms/soles  11.8 (7.3–16.2)
Nails associated with other types of psoriasis  12.6 (10.01–15.1)
Bivariate analysis  Rs  P value 
Correlation between DLQI and PASI scores  .342  <.001 
Correlation between total DLQI and individual domain scores  Rs  P value 
Symptoms and feelings  .612  <.001 
Daily activities  .754  <.001 
Leisure  .812  <.001 
Work/school  .656  <.001 
Personal relationships  .704  <.001 
Treatment  .555  <.001 

Abbreviations: DLQI, Dermatology Life Quality Index; IQR, interquartile range; Rs, Spearman correlation coefficient.


K–S statistic (P<.05).

The profile and clinical characteristics of the study population were similar to those described elsewhere. The proportion of patients with impaired quality of life according to the DLQI, 85.9%, was also similar.3,4 In total, 41.1% of the respondents had a DLQI score of more than 10, indicating that they perceived psoriasis as having a very large or extremely large effect on their quality of life.

The most widely affected DLQI domain was the symptoms and feelings domain (questions 1 and 2), indicating that these aspects are important to patients and highlighting the tendency to experience itching and pain and feelings of embarrassment and self-consciousness. These findings were similar to those reported elsewhere.5,6

Patients aged 25 to 34 years had a median DLQI score of 12, the highest by age group (P<.05). People in this age group tend to be occupationally, socially, and sexually active and to have significant concerns and feelings of stigma about their personal appearance. Older adults, as observed in our study, appear to be less affected in these domains, probably because their situation is more stable in terms of work, social life, and personal relationships.

Supporting reports in the literature, DLQI scores were similar in men and women. Scores above the mean were observed in patients with psoriasis in special locations and patients with hypothyroidism, diabetes mellitus, or psoriatic arthritis.4,6–8 Lower scores were observed in patients treated with biologics, although the differences were not significant when compared with other treatments (P=.776). We consider that the potential positive effects of biologic therapy on quality of life in our population should be confirmed using different study designs, as shown by other authors.9

We observed a weak correlation between DLQI and Psoriasis Area and Severity Index (PASI) scores, indicating that factors other than clinical severity influence quality of life in psoriasis. This poor correlation has been highlighted by other authors and suggests that evaluations based on visible signs and symptoms may not reflect patient perceptions or the true impact of psoriasis on quality of life.10

The finding of a highly positive correlation between each of the dimensions of the DLQI and total DLQI score is notable and indicates a strong association between overall quality of life and perceived effects on work, treatments, and emotional, social, and sexual functioning.5

The limitations of our study include potential biases due to its retrospective observational design, a low percentage of patients on biologic therapy (impeding fair comparisons with other treatments), inclusion of patients from just two centers, and a relatively small overall sample.

In conclusion, we observed high rates of quality of life impairment, in some cases severe, in this series of patients with psoriasis. Our findings confirm previous reports that factors other than clinical severity affect patient-perceived quality of life, highlighting the importance of overall assessments including physical, social, emotional, among other dimensions.

Conflicts of Interest

Dr. Piedad M. Guavita declares that she has no conflicts of interest.

Dr. Castro Ayarza has received consultancy or speaker fees for activities sponsored by AbbVie, Amgen, Biopas-UCB, Janssen, and Novartis.

Dr. Cortés Correa and Dr. Peñaranda Contreras have participated in clinical trials sponsored by Novartis, Sanofi, and Roche and have received consultancy or speaker's fees in activities sponsored by Novartis, Sanofi, Janssen, Lilly, and Pharmalab.

K. Lesner, A. Reich, J.C. Szepietwoski, F.J. Dalgard, U. Gieler, L. Tomas-Aragones, et al.
Determinants of psychosocial health in psoriatic patients: a multi-national study.
Acta Derm Venereol, 97 (2017), pp. 1182-1188
F.M. Ali, A.C. Cueva, J. Vyas, A.A. Atwan, M.S. Salek, A.Y. Finlay, et al.
A systematic review of the use of quality-of-life instruments in randomized controlled trials for psoriasis.
Br J Dermatol, 176 (2017), pp. 577-593
C. Cortés, J.R. Castro-Ayarza, E. Fierro, C. Ojeda.
Calidad de vida de pacientes con psoriasis en un hospital de tercer nivel. Comunicación de 59 casos.
Dermatol Rev Mex, 54 (2010), pp. 125-132
R. Rojas, H. Castellanos, E. Peñaranda.
Prevalencia del síndrome metabólico, gravedad clínica y calidad de vida en pacientes con psoriasis del Hospital Universitario de La Samaritana.
Rev Asoc Colomb Dermatol, 21 (2013), pp. 220-225
S. Vinaccia, J.M. Quiceno, A.M. Martínez, C.P. Arbeláez.
Calidad de vida relacionada con la salud, emociones negativas y apoyo social en pacientes con psoriasis vulgar.
Psicología & Salud, 18 (2008), pp. 17-25
L. Lundberg, M. Johannesson, M. Silverdahl, C. Hermansson, M. Lindberg.
Health-related quality of life in patients with psoriasis and atopic dermatitis measured with SF-36, DLQI and a subjective measure of disease activity.
Acta Derm Venereol, 80 (2000), pp. 430-434
T.Z. Palijan, D. Kovacević, E. Koić, K. Ruzić, F. Dervinja.
The impact of psoriasis on the quality of life and psychological characteristics of persons suffering from psoriasis.
Coll Antropol, 35 (2011), pp. 81-85
J.M. Hernánz, M. Sánchez-Regaña, R. Izu, V. Mendiola, C. García-Calvo.
Clinical and therapeutic evaluation of patients with moderate to severe psoriasis in Spain: the Secuence study.
Actas Dermosifiliogr, 103 (2012), pp. 897-904
R.M. Fernández-Torres, S. Pita-Fernández, E. Fonseca.
Quality of life and related factors in a cohort of plaque-type psoriasis patients in La Coruna, Spain.
Int J Dermatol, 53 (2014), pp. e507-e511
W.H. Boehncke, N.C. Brembilla.
Unmet needs in the field of psoriasis: pathogenesis and treatment.
Clin Rev Allergy Immunol, 55 (2018), pp. 295-311
Actas Dermo-Sifiliográficas
Opciones de artículo
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?