Información de la revista
Vol. 113. Núm. 1.
Páginas 95-98 (Enero 2022)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 113. Núm. 1.
Páginas 95-98 (Enero 2022)
Case and Research Letter
Open Access
Sporadic Kerathoacantomas in Young Patients: A Case Series and a Proposed Diagnostic Algorithm
Queratoacantomas esporádicos en pacientes jóvenes: serie de casos y propuesta de algoritmo diagnóstico
Visitas
...
A. Tolla,
Autor para correspondencia
atoll@clinic.cat

Corresponding author.
, D. Sitjasb, D. Morgado-Carrascoa, R.M. Pujolc,d
a Departamento de Dermatología, Hospital Clínic de Barcelona, Universidad de Barcelona, Barcelona, Spain
b Departamento de Dermatología, Hospital Universitari Josep Trueta, Girona, Spain
c Departamento de Dermatología, Hospital del Mar, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain
d Grupo de Enfermedades Dermatológicas Inflamatorias y Neoplásicas, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain
Contenido relaccionado
A. Toll, D. Sitjas, D. Morgado-Carrasco, R.M. Pujol
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (2)
Tablas (1)
Table 1. Cases reported in the literature of patients with Muir-Torre syndrome-associated keratoacanthomas.
Texto completo
Dear Editor,

Keratoacanthomas (KAs) are usually sporadic and solitary lesions appearing in patients on sun-exposed areas. Chronic sun-exposure, imiquimod, BRAF inhibitors and hedgehog pathway inhibitors can be triggering agents. Genetic causes of KAs such as Ferguson-Smith syndrome (multiple self-healing squamous epitheliomas -MSSE) and generalized eruptive keratoacanthoma (Grzybowski syndrome) are characterized by the development of dozens to hundreds of KAs at a young age and are not associated with other cutaneous or extracutaneous tumours1. Other associated genetic diseases are xeroderma pigmentosum (XP) and Muir-Torre syndrome (MTS).

We sought to describe the clinical-epidemiological characteristics and associated genetic disorders of young patients with KAs in our centers, and to develop a diagnostic algorithm. We describe three patients who developed KAs before age 40 and who harbored unrecognized genetic diseases predisposing to these cutaneous lesions.

Patient 1 was a 54-year-old male with no relevant family history and a personal history of intense sunlight exposure who had had more than ten KAs since age 39. He developed growing centrifugal lesions on the left forearm after radiotherapy for a solitary KA. The lesions were clinically and histologically suggestive of keratoacanthoma marginatum centrifugum (KMC) (Fig. 1). No loss of MMR immunohistochemical markers was observed in the tumors, and the lesions were successfully treated with intralesional 5-fluorouracil and oral retinoids. A screen analysis of the TGFBR1 gene and a likely pathogenic c.301 T>C heterozygous variant was detected.

Figure 1.

Keratoacanthoma marginatum centrifugum. Dome-shaped keratinizing pink to skin-colored nodules 1 to 2 centimeters in diameter with a central keratotic plug, distributed at the periphery of the previous radiation field (left forearm).

(0,11MB).

Patient 2 was an otherwise healthy 38-year-old male who developed a rapidly growing KA measuring 13 mm on the nose. His father had died at age 53 after developing metastatic colon cancer. MMR immunohistochemical showed loss of MSH2 and MSH6. The lesion was treated with intralesional methotrexate, showing complete regression in a 12-week period. A constitutional c.142G>T heterozygous mutation in the MSH2 gene (predicted to generate a truncating protein, p.Glu48*) was identified by means of a next generation sequencing panel and a Sanger sequencing validation, confirming the diagnosis of Lynch syndrome.

Patient 3 was an otherwise healthy male with no family history who developed a 17 mm diameter KA in the cervical region at age 38. The lesion was surgically excised and MMR immunohistochemical stains showed loss of MSH2 and MSH6. A germinal MMR gene study showed a large deletion (c.(?_68)_1276+?del) involving exons 1 to 7 in the MSH2 gene, confirming the diagnosis of Lynch syndrome, MTS subtype. The patient developed a high grade pT2 carcinoma in the ureter at age 41. Several facial sebaceous adenomas and a KA in the cervical region have also been removed to date.

The development of solitary or multiple KAs at a young age may be the presenting sign of genetic disorders which may be associated with malignant neoplasms. Recognizing such associations is important in order to prevent possible complications.

MSSE, an autosomal dominant disease, is caused by mutations in the TGFBR1 gene together with permissive variants at a locus near the TGFBR1 locus on chromosome 92. Patients with MSSE develop multiple lesions which grow slowly and resolve within months, while new lesions appear. There is variable penetrance, ranging from asymptomatic carriers to patients developing lesions from the first to the seventh decade of life. Some patients may show KCM lesions, characterized by the development of coral reef-like lesions with progressive peripheral expansion and atrophic central healing. The development of KCM after radiotherapy, should suggest the diagnosis of MSSE3. Alternative treatment modalities such as oral retinoids, corticosteroids or intralesional/systemic methotrexate can be used.4

XP is associated with the early development of skin cancer but KAs are seldom the first tumor manifestation. MTS is reported in 10-30% of families with Lynch syndrome mainly harboring mutations of MSH2 or MLH1 genes5,6. MMR immunohistochemical markers should be assayed on tumor samples from patients with sebaceous cutaneous neoplasms, multiple KAs and/or appearing at a young age. However, the lack of expression of MMR proteins in sebaceous neoplasms is not exclusive to patients with MTS and some cases which maintain the expression of the MMR proteins have an underlying germline DNA repair defect.

A literature review shows that approximately 89% of the patients with MTS-associated KAs harbor MSH2 mutations, (Table 1), which is in accordance with the reported mutational prevalence of non-KA cutaneous neoplasms in MTS5–10. MTS-associated KAs7 are often indistinguishable histologically from sporadic KAs. KAs in patients with MTS usually develop before the diagnosis of visceral neoplasms is performed, while sebaceous tumors in MTS are commonly detected after the diagnosis of visceral malignancies.

Table 1.

Cases reported in the literature of patients with Muir-Torre syndrome-associated keratoacanthomas.

Author, year  Sex  Number of KAs  Age of presentation (years)  Location  Loss MMR (IHC) In KA  MSI  Other skin lesions  Visceral tumour in the proband (age in years)  Family history of visceral malignancies  Germinal mutation 
Muir et al, 19677  32  Face  NR  NR  NR  -Larynx squamous cell carcinoma (38)  No  NR 
                -Adenocarcinoma duodenum/ileum (40)     
Mangold et al, 20046  NR  50  NR  MSH2  Yes  -Sebaceous adenoma  -Transitional cell carcinoma ureter (66)  -Uterine cancer, small intestinal cancer, abdominal cancer (mother)  MSH2 (c.1578delC) 
              -Squamous cell carcinoma  -Carcinoma of jejunum (66)  -Breast cancer (maternal uncle)   
Mangold et al, 20046  NR  Multiple  57  NR  NR  Yes  Multiple sebaceous tumours  -Urothelial carcinoma (56)  -Colorectal cancer (brother)  MSH2 (Deletion exons 9,10) 
Mangold et al, 20046  NR  67  NR  NR  NR  Multiple sebaceous tumours  -Multiple colon carcinomas (age unknown)  -Colorectal cancer (father, brother)  MSH2 (c.2005. 2T>C) 
Mangold et al, 20046  NR  Multiple  52  NR  No  Yes  Sebaceous hyperplasias  -Urothelial cancer (52).  -Colon carcinoma (father)  MSH2 (c1571. G>C) 
                -Bladder cancer. (53)     
                -Colon carcinomas (54)     
Ponti et al, 20058  -34  -Neck  MSH2/MSH6  Yes  Sebaceous cysts  -Colon (35)  -Bladder  MSH2(c2131C>T) 
      -44  -Chest        -Renal pelvis (54)  -Breast   
        -Head             
Ponti et al, 20058  -86  Head  -MLH1  Yes  NR  Gastric (89)  -Breast  NR 
                  -Gastric   
Stella et al, 200711  NR  NR  NR  NR  NR  NR  NR  Colon  NR  MSH2 (exons 1-6 deletion) 
South et al, 20085  39  NR  -MLH1  NR  -Sebaceous adenoma  Colon (46)  NR  MLH1 (c.1489delC) 
South et al, 20085  57  NR  NR  NR  NR  None  Colon (daughter)  MSH2 (c942. 3A>T) 
South et al, 20085  41  NR  NR  NR  NR  Colon (41)  NR  MSH2 (c942. 3A>T) 
South et al, 20085  63  NR  NR  NR  NR  -Endometrial (64)  NR  MSH2 (c942. 3A>T) 
                -Colon (71)     
South et al, 20085  56  NR  NR  NR  NR  -Colon (58)  NR  MSH2 (c942. 3A>T) 
South et al, 20085  50  NR  NR  NR  NR  -Colon (60)  NR  MSH2 (Exon 1-6, delet) 
Frogatt et al, 199510  50  NR  NR  NR  NR  Colon (50)  NR  MSH2 linkage 
                Uterine (50)     
Current report  38  Nose  MSH2/MSH6  NP  No  None  -Colon adenocarcinoma (father)  MSH2 (c142 G>T) 
Current report  38  Neck  MSH2/MSH6  NP  Sebaceous adenomas  Urothelial carcinoma (41)  None  MSH2 (c.(?_68)_1276+?del) 

Abbreviations: KA: Keratoacanthoma; M: Male; F: Female; NR: Not reported; MMR: Mismatch repair protein expression; IHC: Immunohistochemistry.

A diagnostic algorithm (Fig. 2) for patients who are 50 years or younger and develop sporadic KAs is proposed. This algorithm rests on three pillars: the presence of a family history of KAs/colorectal cancer, immunohistochemical stains for MMR proteins and genetic studies of MMR genes and germinal alterations in the TGFBR1 gene.

Figure 2.

Diagnostic algorithm for patients who are 50 years or younger and develop sporadic KAs.

Abbreviations: MMR, mismatch repair.

(0,23MB).
Acknowledgements

We thank Dr Marta Pineda, Joan Brunet, Eleanor Reavey and David Goudie for assistance with the genetic study of the cases reported in this work and for comments that improved the manuscript.

References
[1]
B. Kwiek, R.A. Schwartz.
Keratoacanthoma (KA): an update and review.
J Am Acad Dermatol, 74 (2016), pp. 1220-1233
[2]
H.C. Kang, D.A. Quigley, I.-J. Kim, Y. Wakabayashi, M.A. Ferguson-Smith, M. D’Alessandro, et al.
Multiple self-healing squamous epithelioma (MSSE): rare variants in an adjacent region of chromosome 9q22.3 to known TGFBR1 mutations suggest a digenic or multilocus etiology.
J Invest Dermatol, 133 (2013), pp. 1907-1910
[3]
D.P. Lindsay, J. Kharofa, M. Junck, E. Olasz, J.F. Wilson.
Eruptive keratoacanthomas after radiation therapy for keratoacanthoma centrifugum marginatum.
Pract Radiat Oncol, 5 (2015), pp. 203-206
[4]
C. Mangas, I. Bielsa, M. Ribera, M.T. Fernández-Figueras, C. Ferrándiz.
A case of multiple keratoacanthoma centrifugum marginatum.
Dermatol Surg Off Publ Am Soc Dermatol Surg Al, 30 (2004), pp. 803-806
[5]
C.D. South, H. Hampel, I. Comeras, J.A. Westman, W.L. Frankel, A. de la Chapelle.
The frequency of Muir-Torre syndrome among Lynch syndrome families.
J Natl Cancer Inst, 100 (2008), pp. 277-281
[6]
E. Mangold, C. Pagenstecher, M. Leister, M. Mathiak, A. Rütten, W. Friedl, et al.
A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome.
J Med Genet, 41 (2004), pp. 567-572
[7]
E.G. Muir, A.J. Bell, K.A. Barlow.
Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face.
Br J Surg, 54 (1967), pp. 191-195
[8]
G. Ponti, L. Losi, C. Di Gregorio, L. Roncucci, M. Pedroni, A. Scarselli, et al.
Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas: role of clinical features, microsatellite instability, and immunohistochemistry.
Cancer, 103 (2005), pp. 1018-1025
[9]
A. Stella, N.C. Surdo, P. Lastella, D. Barana, C. Oliani, M.G. Tibiletti, et al.
Germline novel MSH2 deletions and a founder MSH2 deletion associated with anticipation effects in HNPCC.
Clin Genet, 71 (2007), pp. 130-139
[10]
N.J. Froggatt, J. Koch, R. Davies, D.G. Evans, A. Clamp, O.W. Quarrell, et al.
Genetic linkage analysis in hereditary non-polyposis colon cancer syndrome.
J Med Genet, 32 (1995), pp. 352-357
[11]
A. Stella, N.C. Surdo, P. Lastella, D. Barana, C. Oliani, M.G. Tibiletti, et al.
Germline novel MSH2 deletions and a founder MSH2 deletion associated with anticipation effects in HNPCC.
Clin Genet, 71 (2007), pp. 130-139
Copyright © 2021. AEDV
Idiomas
Actas Dermo-Sifiliográficas

Suscríbase a la newsletter

Opciones de artículo
Herramientas
es

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?