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Vol. 103. Issue 1.
Pages 5-11 (January - February 2012)
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Vol. 103. Issue 1.
Pages 5-11 (January - February 2012)
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DOI: 10.1016/j.adengl.2011.03.016
Skin Bioengineering: Preclinical and Clinical Applications
Bioingeniería cutánea: aplicaciones preclínicas y clínicas
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L. Martínez-Santamaríaa, S. Guerrero-Aspizuab, M. Del Ríoa,b,??
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marcela.delrio@ciemat.es

Corresponding author.
a Unidad de Medicina Regenerativa, Departamento de Investigación Básica, División de Biomedicina Epitelial, Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT) y Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Madrid, Spain
b Departamento de Bioingeniería, Universidad Carlos III (UC3 M), Madrid, Spain
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Abstract

Regenerative Medicine is an emerging field that combines basic research and clinical observations in order to identify the elements required to replace damaged tissues and organs in vivo and to stimulate the body's intrinsic regenerative capacity. Great benefits are expected in this field as researchers take advantage of the potential regenerative properties of both embryonic and adult stem cells, and more recently, of induced pluripotent stem cells. Bioengineered skin emerged mainly in response to a critical need for early permanent coverage of extensive burns. Later this technology was also applied to the treatment of chronic ulcers. Our group has established a humanized mouse model of skin grafting that involves the use of bioengineered human skin in immunodeficient mice. This model is suitable for the study of physiologic and pathologic cutaneous processes and the evaluation of treatment strategies for skin diseases, including protocols for gene and cell therapy and tissue engineering.

Keywords:
Tissue engineering
Regenerative medicine
Stem cells
Humanized mouse models of skin diseases
Experimental dermatology
Resumen

La Medicina Regenerativa es un campo emergente que combina la investigación básica y la experiencia clínica con el objetivo de proporcionar los elementos necesarios para reemplazar in vivo tejidos y órganos dañados, estimulando además la capacidad regenerativa intrínseca del organismo. Se esperan grandes avances en este campo en los próximos años, debido a las potenciales propiedades regenerativas de las células madre embrionarias y adultas, y más recientemente de las células madre pluripotentes inducidas.

La bioingeniería cutánea surgió motivada principalmente por la necesidad crítica de dar cobertura permanente a grandes quemados, y posteriormente se ha empleado también en el tratamiento de úlceras crónicas. Nuestro equipo ha desarrollado un modelo preclínico humanizado basado en el trasplante de piel bioingenierizada a ratones inmunodeficientes que posibilita el estudio de procesos fisiológicos y patológicos cutáneos, así como la evaluación de estrategias terapéuticas de intervención dermatológica, incluyendo protocolos de terapia génica y celular e ingeniería tisular.

Palabras clave:
Ingeniería de tejidos
Medicina regenerativa
Células madre
Modelos humanizados de enfermedades cutáneas
Dermatología experimental

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