Journal Information
Vol. 98. Issue 3.
Pages 194-197 (April 2007)
Vol. 98. Issue 3.
Pages 194-197 (April 2007)
Case reports
DOI: 10.1016/S1578-2190(07)70425-0
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Primary Cutaneous Anaplastic CD30+ Large Cell Lymphoma
Linfoma Primario Cutáneo Anaplásico de Células Grandes CD301
M.D. Marrero-Calvoa,??
Corresponding author

Correspondence: San Francisco de Borja, n.° 1; 1-1, 46701 Gandía, Valencia, Spain.
, M. Rodríguez-Sernaa, P. Castejón-Calvetea, S. Peláez-Malagónb
a Servicio de Dermatología, Hospital San Francisco de Borja, Gandía, Valencia, Spain
b Anatomía Patológica, Hospital San Francisco de Borja, Gandía, Valencia, Spain
Article information

Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75% of neoplastic cells. Currently it is considered a low grade lymphoma with favorable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up.

Key words:
primary cutaneous anaplastic CD30+ large cell lymphoma

El linfoma cutáneo primario anaplásico de células grandes CD30+ (LCPCG) forma parte del espectro de las enfermedades cutáneas primarias linfoproliferativas CD30+, junto a la papulosis linfomatoide. Afecta fundamentalmente a pacientes de edad avanzada, en forma de nódulos cutáneos con tendencia a la ulceración. El estudio histológico e inmunohistoquímico demuestra la expresión del antígeno CD30 en más del 75% de las células neoplásicas. Actualmente se considera un linfoma de bajo grado de malignidad, con buen pronóstico y buena respuesta a tratamientos como la radioterapia local, el metotrexato o la cirugía. Presentamos un caso en una paciente de 93 años con nódulos ulcerados en la pierna derecha. El estudio histológico e inmunohistoquímico confirmó el diagnóstico de LCPCG CD30+, de origen no T no B. La paciente fue tratada con radioterapia local con resolución paulatina de los nódulos cutáneos y sin mostrar recidiva en los 6 meses de seguimiento.

Palabras clave:
linfoma cutáneo primario anaplásico de células grandes CD30+
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Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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