Journal Information
Vol. 98. Issue 3.
Pages 194-197 (April 2007)
Vol. 98. Issue 3.
Pages 194-197 (April 2007)
Case reports
DOI: 10.1016/S1578-2190(07)70425-0
Full text access
Primary Cutaneous Anaplastic CD30+ Large Cell Lymphoma
Linfoma Primario Cutáneo Anaplásico de Células Grandes CD301
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M.D. Marrero-Calvoa,??
Corresponding author
marrero_mdo@gva.es

Correspondence: San Francisco de Borja, n.° 1; 1-1, 46701 Gandía, Valencia, Spain.
, M. Rodríguez-Sernaa, P. Castejón-Calvetea, S. Peláez-Malagónb
a Servicio de Dermatología, Hospital San Francisco de Borja, Gandía, Valencia, Spain
b Anatomía Patológica, Hospital San Francisco de Borja, Gandía, Valencia, Spain
Article information
Abstract

Primary cutaneous anaplastic CD30+ large cell lymphoma (PCALCL) is part of the spectrum of primary cutaneous CD30+ lymphoproliferative disorders together with lymphomatoid papulosis. It affects mainly elderly patients and presents as skin nodules that tend to ulcerate. Histological and immunohistochemical study show the expression of CD30 antigen in more than 75% of neoplastic cells. Currently it is considered a low grade lymphoma with favorable prognosis and good response to treatments such as local radiotherapy, methotrexate or surgery. We report a 93-year-old patient with ulcerated nodules in her right leg. Histological and immunohistochemical study confirmed the diagnosis of PCALCL, of non-B, non-T origin. The patient was treated with local radiotherapy with progressive resolution of skin nodules and absence of relapse at 6 months follow-up.

Key words:
primary cutaneous anaplastic CD30+ large cell lymphoma
inmunophenotype
radiotherapy
Resumen

El linfoma cutáneo primario anaplásico de células grandes CD30+ (LCPCG) forma parte del espectro de las enfermedades cutáneas primarias linfoproliferativas CD30+, junto a la papulosis linfomatoide. Afecta fundamentalmente a pacientes de edad avanzada, en forma de nódulos cutáneos con tendencia a la ulceración. El estudio histológico e inmunohistoquímico demuestra la expresión del antígeno CD30 en más del 75% de las células neoplásicas. Actualmente se considera un linfoma de bajo grado de malignidad, con buen pronóstico y buena respuesta a tratamientos como la radioterapia local, el metotrexato o la cirugía. Presentamos un caso en una paciente de 93 años con nódulos ulcerados en la pierna derecha. El estudio histológico e inmunohistoquímico confirmó el diagnóstico de LCPCG CD30+, de origen no T no B. La paciente fue tratada con radioterapia local con resolución paulatina de los nódulos cutáneos y sin mostrar recidiva en los 6 meses de seguimiento.

Palabras clave:
linfoma cutáneo primario anaplásico de células grandes CD30+
inmunofenotipo
radioterapia
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References
[1.]
W. Kempf.
CD30 lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators.
J Cutan Pathol, 33 (2006), pp. 58-70
[2.]
D.N. Slater.
The new World Health Organization-European Organization for Research and Treatment of Cancer classification for cutaneous lymphomas: a practical marriage of two giants.
Br J Dermatol, 153 (2005), pp. 874-880
[3.]
R. Willemze, R.C. Beljaards.
Spectrum of primary cutaneous CD-30(Ki-1)-positive lymphoproliferative disorders: a proposal for classification and guidelines for management and treatment.
J Am Acad Dermatol, 28 (1993), pp. 973-980
[4.]
C. Akiyama, N. Shibagaki, N. Yasaka, N. Ohtake, Y. Kubota, O. Takayama, et al.
Primary cutaneous CD30(Ki-1)-positive lymphoma of non-T, non-B origin.
Dermatology, 190 (1995), pp. 238-241
[5.]
S.E. Chang, I.J. Park, J. Huh, J.H. Choi, K.J. Sung, K.C. Moon, et al.
CD56 expression in a case of primary cutaneous CD30+ anaplastic large cell lymphoma.
Br J Dermatol, 142 (2000), pp. 766-770
[6.]
S.M. Cooper, G.D. Turner, K. Hollowood, K. Gatter, C. Hatton, D. Gray, et al.
Primary cutaneous large cell CD30 + lymphoma in a renal transplant recipient.
Br J Dermatol, 149 (2003), pp. 426-428
[7.]
N. Pimpinelli.
Primary cutaneous CD30 + T-cell lymphomas: hypothesis for a highly distinctive clinicobiological behaviour.
J Eur Acad Dermatol Venereol, 15 (2001), pp. 108-109
[8.]
K. Sasaki, M. Sugaya, H. Fujita, K. Takeuchi, H. Torii, A. Asahina, et al.
A case of primary cutaneous anaplastic large cell lymphoma with variant anaplastic lymphoma kinase translocation.
Br J Dermatol, 150 (2004), pp. 1202-1207
[9.]
E.C. Vonderheid, A. Sajjadian, M.E. Kadin.
Methotrexate is effective therapy for lymphomatoid papulosis and other primary cutaneous CD30-positive lymphoproliferative disorders.
J Am Acad Dermatol, 34 (1996), pp. 470-481
[10.]
B. Didona, R. Benucci, P. Amerio, F. Canzona, O. Rienzo, R. Cavalieri.
Primary cutaneous CD30 + T-cell lymphoma responsive to topical imiquimod (Aldara).
Br J Dermatol, 150 (2004), pp. 1198-1201
[11.]
M.C. De Nisi, A. D’Amuri, A.V. Lalinga, R. Occhini, M. Biagioli, C. Miracco.
Posttransplant primary cutaneous CD30 (Ki-1)-positive anaplastic large T-cell lymphoma. A case report.
Br J Dermatol, 152 (2005), pp. 1068-1070
[12.]
C.H. Wang, H.C. Nien, M.F. Hou, G.S. Chen, S.T. Cheng.
Sentinel lymphadenectomy for circumscribed cutaneous T-cell lymphoma.
Dermatol Surg, 30 (2004), pp. 952-956
[13.]
K.U. Kramer, H. Starz, B.R. Balda.
Primary cutaneous CD30-positive large T-cell lymphoma with secondary lymph node involvement detected by sentinel lymphonodectomy.
Acta Derm Venereol, 82 (2002), pp. 73-74
[14.]
M.M. Tomaszewski, J.C. Moad, G.P. Lupton.
Primary cutaneous KI-1(CD30) positive anaplastic large cell lymphoma in childhood.
J Am Acad Dermatol, 40 (1999), pp. 857-861
[15.]
R.L. Ten Berge, J.J. Oudejans, G.J. Ossenkoppele, C.J. Meijer.
ALK-negative systemic anaplastic large cell lymphoma: differential diagnostic and prognosis aspects-a review.
J Pathol, 200 (2003), pp. 4-15
[16.]
A.H. Sarris, R. Luthra, V. Papadimitracopoulou, M. Waasdorp, M.A. Dimopoulos, J.A. McBride, et al.
Amplification of genomic DNA demonstrates the presence of the t(2;5)(p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis.
Blood, 88 (1996), pp. 1771-1779
[17.]
S. Salama.
Primary “cutaneous” T-cell anaplastic large cell lymphoma, CD30+, neutrophil-rich variant with subcutaneous panniculitic lesions, in a post-renal transplant patient: report of unusual case and literature review.
Am J Dermatopathol, 27 (2005), pp. 217-223
[18.]
H. Yurtsever, W. Kempf, R.H. Laeng.
Posttransplant CD30+ anaplastic large cell lymphoma with skin and lymph node involvement.
Dermatology, 207 (2003), pp. 107-110
Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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