Journal Information
Vol. 110. Issue 4.
Pages 325-327 (May 2019)
Vol. 110. Issue 4.
Pages 325-327 (May 2019)
Case and Research Letters
DOI: 10.1016/j.adengl.2019.02.009
Full text access
Effectiveness of 904nm Gallium-Arsenide Diode Laser in Treatment of Oral Lichen Planus: Report of 2Cases
Eficacia del láser de diodo de arseniuro de galio en el tratamiento de 2 casos de liquen plano oral
P.T. Bhattacharyaa,
Corresponding author

Corresponding author.
, K. Patilb, M.V. Guledgudc
a Profesor asistente, Departamento de Medicina Oral y Radiología, Facultad y Hospital Sarjug Dental, Darbhanga, Bihar, India
b Profesor y jefe, Departamento de Medicina Oral y Radiología, Facultad JSS Dental, Mysore, Karnataka
c Profesor, Departamento de Medicina Oral y Radiología, Facultad JSS Dental, Mysore, Karnataka, India
Article information
Full Text
Download PDF
Figures (2)
Full Text
To the editor:

Two symptomatic non-pregnant female patients with clinically and histopathologically diagnosed oral lichen planus were selected for the treatment with Low Level Laser Therapy (LLLT). Both the patients were neither suffering from any systemic illness nor were on any systemic drugs. Both the patients had histories of recurrent lesions which were treated before with topical corticosteroids. Ethical clearance was obtained from the Ethical Clearance Committee of the college and written informed consent form was obtained from the patients.

The subjective assessment of pain and burning sensation was done on Visual Analogue Scale(VAS) before start of treatment, after 5 and 10 sessions, and after one month post treatment. VAS is a 10cm long horizontal line where 0 represent “no pain” and 10 represent “worst possible pain”.1 The objective assessment of the lesions was done based on Clinical Scoring Scale of Thongprasom et al.2 The lesions were measured with the help of marked tongue blade. The clinical scoring criteria used were as follows:

  • -

    Score 5=white striae with erosive area> 1cm2

  • -

    Score 4=white striae with erosive area <1cm2

  • -

    Score 3=white striae with atrophic area> 1cm2

  • -

    Score 2=white striae with atrophic area <1cm2

  • -

    Score 1=mild white striae, no erythematous area

  • -

    Score 0=no lesion, normal mucosa

The score of 0 or 1 after 10 sessions of LLLT or before was considered complete resolution.

The gallium arsenide diode laser (low–intensity LASER, Prometheus-M, New Delhi, 2001, LASER class: III B, Wavelength: 904nm, Power supply & consumption: 220V & 10W was directed towards the lesions through fiber-optic nozzles at a 5mm distance from the lesions at 4 – 6 points for 5minutes at each point with a frequency of 1500 HZ thrice weekly on alternate days for 10 sessions or till the lesions heal. The international safety procedures for LASER application were respected. The first patient had erosive lichen planus on lower lip since 15 days and had clinical score of 5 and VAS of 6 before treatment. The patient showed complete resolution of the lesion after 5 sessions of LLLT. There was no recurrence in the one year follow up period. The second patient had erosive-reticular lesion on right buccal mucosa (Fig. 1) for one month and clinical score of 5 and VAS of 7 before treatment. The patient showed almost complete resolution of the lesion post 9 sessions of LLLT therapy with clinical score and VAS score of 1 (Fig. 2). The patient was asymptomatic and there had been no recurrence of the lesion one year post treatment.

Figure 1.

Second patient's pre-treatment photograph showing erythematous reticular lesion on buccal mucosa.

Figure 2.

Second patient's post-treatment photograph.


Lichen planus is a T cell mediated potentially premalignant condition that affects mucosal and cutaneous tissues. It was first described by Erasmus Wilson in 1869 as “leichen planus”. The overall prevalence of lichen planus is reportedly 0.22% to 5% worldwide.3

The word LASER is an ellipsis for “Light Amplification by Stimulated Emission of Radiation”. Therapeutic lasers are within red to near visible red electromagnetic spectrum ranging from 630 to 980nm. LLLT is based on Arndt-Schulz principle which states that if the stimulus is too weak, no effect is seen. Increased stimulation and optimal dose leads to the optimal effect; while further dose increase leads to a decreased effect.4

The various effects of LLLT on tissues are as follows5

They act analgesically by enhancing release of endorphin and thus inhibit nociceptive signals and control pain mediators.

The inflamed /pathologic tissues are acidic in nature. LLLT act on cellular reduction-oxidative potential so that the pH becomes optimally alkaline.

LLLT has anti-inflammatory effect as it stimulates lymphocytes, activate mast cells and increase production of adenosine –triphosphate in the mitochondria.

These lasers stimulate microcirculation which results in the change of capillary hydrostatic pressure which in turn helps in edema reduction.

LLLT increase ascorbic acid in fibroblast thus increasing hydroxyproline production and consequently collagen production. Thus, helping in tissue healing and repair.

LLLT improve proliferation of the epithelial cells which leads to increased number of blood vessels as well as enhanced production of granulation tissue.

Various studies and case reports have reported the efficacy of LLLT in treatment of myriad of mucosal lesions and disorders such as oral mucositis, pemphigus vulgaris, recurrent aphthous stomatitis, herpes simplex and oral lichen planus.6–10 We also successfully treated two cases of OLP with 904nm GaAr Laser.

As of now, it can be concluded that LLLT may be an alternative booming mode of treatment for OLP. The substantial deductions on efficacy of LLLT in treatment of OLP can be arrived only after conducting more studies on larger sample sizes and among different ethnic groups.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

J. Scott, E.C. Huskisson.
Graphic representation of pain.
Pain, 2 (1976), pp. 175-184
K. Thongprasom, L. Luangjarmekorn, T. Sererat, W. Taweesap.
Relative efficacy of fluocinolone acetonide compared with triamcinolone acetonide in treatment of oral lichen planus.
J Oral Pathol Med, 21 (1992), pp. 456-458
F. Gorouhi, P. Davari, N. Fazel.
Cutaneous and mucosal lichen planus: A comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis.
The Scientific World Journal, (2014),
[Article ID 742826]
F. Agha-Hosseini, E. Moslemi, I. Mirzaii-Dizgah.
Comparative evaluation of low-level laser and CO2 laser in treatment of patients with oral lichen planus.
Int J Oral Maxillofac Surg, 41 (2012), pp. 1265-1269
A. Tezel, C. Kara, V. Balkaya, R. Orbak.
An evaluation of different treatment for recurrent aphthous stomatitis and patient perceptions: Nd:YAG laser versus medication.
Photomed Laser Surg, 27 (2009), pp. 101-106
R.G. Cauwels, L.C. Martens.
Low level laser in oral mucositis: A piloty study.
Eur Arch Paediatr Dent, 12 (2011), pp. 118-123
E.M. Minicucci, H.A. Miot, S.R. Barraviera, L. Almeida-Lopes.
Low level laser therapy on the treatment of oral and cutaneous pemphigus vulgaris: case report.
Lasers Med Sci, 27 (2012), pp. 1103-1106
V. Anand, V. Gulati, B. Anand.
Low level laser therapy in the treatment of aphthous ulcer.
Indian J Dent Res, 24 (2013), pp. 267-270
D.C. Ferreira, H.L.B. Reis, F.S. Cavalcante, K.R.N. Sentos, M.R.L. Passos.
Recurrent herpes simplex infections: A laser therapy as a potential tool for long-term successful treatment.
Rev Soc Bras Med Trop, 44 (2011), pp. 397-399
A. Cafaro, P.G. Arduino, G. Massolini, E. Romagnoli, R. Broccoletti.
Clinical evaluation of the efficiency of low level laser therapy for oral lichen planus.
Lasers Med Sci, 29 (2014), pp. 185-190

Please cite this article as: Bhattacharya PT, Patil K, Guledgud MV. Eficacia del láser de diodo de arseniuro de galio en el tratamiento de 2 casos de liquen plano oral. Actas Dermosifiliogr. 2019;110:325–327.

Copyright © 2018. Elsevier España, S.L.U. and AEDV
Actas Dermo-Sifiliográficas (English Edition)

Subscribe to our newsletter

Article options
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
    NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
  • Additional material
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
NOTICE Undefined index: tipo (includes_ws_v2/librerias/html/item.php[1273])
Supplemental materials
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.