Información de la revista
Vol. 98. Núm. 10.
Páginas 657-678 (Diciembre 2007)
Vol. 98. Núm. 10.
Páginas 657-678 (Diciembre 2007)
Review article
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Off-Label Use of Biologic Agents in the Treatment of Dermatosis, Part 1: Infliximab and Adalimumab
Uso de Fármacos Biológicos en Dermatosis Fuera de la Indicación Aprobada. Primera parte: Infliximab y Adalimumab
B. Díaz-Ley
Autor para correspondencia

Correspondence: Servicio de Dermatología, Hospital Universitario de La Princesa, Diego de León, 62, 28006 Madrid, Spain.
, G. Guhl, J. Fernández-Herrera
Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
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In recent years, the therapeutic armamentarium available to dermatologists has been extended thanks to the development of numerous biologic agents. In our field, immunomodulators—although currently only approved for psoriasis—have given rise to new therapeutic possibilities in a number of inflammatory skin diseases. Since these new agents have more specific immunologic mechanisms of action, their efficacy and safety is an improvement on traditional immunosuppressants. Consequently, it is very likely that they will play an important role in dermatology in the next few years. This article, the first part of a review of off-label use of biologic agents in dermatology, describes the anti-tumor necrosis factor-α antibodies infliximab and adalimumab.

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En los últimos años el armamento terapéutico de los dermatólogos se ha incrementado como consecuencia de la introducción de múltiples fármacos biológicos. En Dermatología los inmunomoduladores están aprobados únicamente para la psoriasis. No obstante todos estos medicamentos han abierto nuevas posibilidades de tratamiento para numerosas dermatosis inflamatorias. La eficacia y el perfil de seguridad de estos fármacos puede considerarse mejor al de los inmunosupresores clásicos, dado que actúan sobre mecanismos inmunológicos más específicos, siendo muy probable que en los próximos años estos medicamentos biológicos adquieran un importante papel en el campo de la Dermatología. Este artículo, primera parte de la revisión de usos fuera de indicación de fármacos biológicos en Dermatología, describe los anticuerpos antifactor de necrosis tumoral (TNF): infliximab y adalimumab.

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