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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Acrylic resins are thermoplastic polymers or copolymers of acrylic acid or its esters&#46; Acrylic monomers&#44; with initiators&#44; accelerators&#44; and catalysts as additives&#44; are polymerized in 1 of 2 ways&#58; by exposure to ambient temperature&#44; UV or visible light&#44; or electron beams&#59; or by heating&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Acrylic resins can cause a range of skin problems&#44; including allergic contact dermatitis&#44; irritant contact dermatitis&#44; and contact urticaria&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">In 1998&#44; Bj&#246;rkner<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> published a classification of acrylic resins that is widely accepted and with which we concur&#46; That classification includes monoacrylates&#44; monomethacrylates&#44; multifunctional acrylates&#44; prepolymers&#44; acrylonitrile&#44; acrylamide and derivatives&#44; and cyanoacrylates&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Multifunctional acrylates are used for dental and orthopedic prostheses&#44; glues&#44; adhesives&#44; varnishes&#44; artificial nails&#44; dyes and inks&#44; printing plates&#44; parquet and wood flooring&#44; and sealants for the automotive and iron and steel industries &#40;Loctite&#44; Threebond&#44; and Sta-Lok&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The most important multifunctional acrylates in terms of frequency of sensitization are as follows&#58; hydroxyethyl methacrylate &#40;HEMA&#41;&#44; hydroxypropyl methacrylate &#40;HPMA&#41;&#44; etyleneglycol dimethacrylate &#40;EGDMA&#41;&#44; diethylene glycol dimethacrylate &#40;DEGDMA&#41;&#44; trimethylolpropane triacrylate &#40;TMPTMA&#41;&#44; triethylene glycol dimethacrylate &#40;TREGDMA&#41;&#44; and butanediol dimethacrylate &#40;BUDMA&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We report 4 cases of eczematous allergic contact dermatitis in workers employed in the same company&#46; The dermatitis&#44; which affected both hands&#44; was the result of sensitization to acrylic resins contained in a sealant called Threebond &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">In October 2009 our skin allergy unit was asked to perform a study of 4 patients who worked in the same motorcycle assembly company&#46; The clinical appearance of the palms and between the fingers of both hands was identical in all 4 patients&#44; with extremely pruritic lesions consisting of long-standing vesicles and blisters&#46; The patients obtained sick leave from work and received standard treatment with antihistamines and corticosteroids &#40;topical for 3 patients and oral for 1 patient&#41;&#46; The lesions became cracked and scaly and eventually healed&#46; On returning to work&#44; 3 of the patients experienced immediate relapses &#40;the fourth patient had changed jobs&#41;&#46; The 4 patients had been in contact with oils and greases&#44; and also with the Threebond sealant resin&#44; which the patients themselves attributed as the cause of their dermatitis&#46; Although the use of special protective gloves&#44; made of thick cloth&#44; was mandatory in the company&#44; all 4 patients admitted that they had occasionally failed to use them&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The 3 patients who experienced a relapse were 35&#44; 40&#44; and 32 years old&#44; and their lesions had developed within 1&#46;5 months&#44; 1 year&#44; and 10 months&#44; respectively&#44; of starting to work with the sealant&#46; As mentioned above&#44; the fourth patient had changed jobs&#44; and so was not included in our study&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The 3 patients underwent patch testing using the following series&#58; the standard Spanish Contact Dermatitis and Skin Allergy Research Group &#40;GEIDAC&#41; battery&#59; the Chemotechnique PG-1000 plastics and glues series and MA-1000 &#40;meth&#41;acrylates series &#40;Chemotechnique Diagnostics AB&#44; Vellinge&#44; Sweden&#41;&#59; and the Threebond sealant in 2&#37;&#44; 0&#46;5&#37;&#44; and 0&#46;2&#37; aqueous solutions&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">For all 3 patients&#44; readings at 48 and 96<span class="elsevierStyleHsp" style=""></span>hours were negative for allergens in the GEIDAC battery and in the plastics and glues series&#46; As for the &#40;meta&#41;acrylates series&#44; all 3 patients were positive for HEMA&#44; HPMA&#44; and EGDMA&#44; as well as for the 3 concentrations of Threebond&#59; 1 patient was also positive for TREGDMA&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The literature contains a number of reports of allergic contact dermatitis developing following contact with acrylic resins in the Threebond sealant&#44; presenting with eczema in the acute phase&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#8211;5</span></a> In 2000&#44; Turker and Beck<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> published the results of their study performed between 1983 and 1995&#44; reporting 15&#37; positivity to &#40;meth&#41;acrylates&#46; Of the positive cases&#44; 71&#37; were due to occupational contact&#58; 34&#37; in odontostomatology &#40;dentists&#44; clinical assistants&#44; and dental technicians&#41;&#44; and the remaining 66&#37; in other professions&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">To avoid sensitization and burns during patch testing&#44; it is important to adequately dilute the sealant before applying the corresponding patch&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In summary&#44; our 4 patients&#44; workers employed in the same company&#44; had eczematous allergic contact dermatitis on both hands caused by sensitization to acrylic resins contained in the Threebond sealant&#46; The lesions would probably have been avoided had the patients assiduously worn the gloves provided by the company&#46; This underlines the need&#44; in certain occupations&#44; to ensure absolute compliance with all protective measures aimed at preventing direct or airborne contact of the skin with possible allergens or irritants&#46;A number of other cases of dermatitis caused by the same material have been reported in Spain for other occupations&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#8211;10</span></a></p></span>"
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Información de la revista
Vol. 102. Núm. 6.
Páginas 468-469 (agosto 2011)
Vol. 102. Núm. 6.
Páginas 468-469 (agosto 2011)
Case and research letter
Acceso a texto completo
Occupational Contact Dermatitis Due to an Acrylic Resin (ThreeBond): 4 Cases in the Same Company
Dermatitis de contacto profesional por Threebond®. Cuatro casos en la misma empresa
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8348
C. Romagueraa, J. Vilaplanaa, M. Llagosterab, R. Grimalta,
Autor para correspondencia
grimalt@ub.edu

Corresponding author.
a Unidad de Alergia, Servicio Dermatología, Hospital Clinic, Barcelona, Spain
b Dermatología, Mútua Universal, Barcelona, Spain
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To the Editor:

Acrylic resins are thermoplastic polymers or copolymers of acrylic acid or its esters. Acrylic monomers, with initiators, accelerators, and catalysts as additives, are polymerized in 1 of 2 ways: by exposure to ambient temperature, UV or visible light, or electron beams; or by heating.

Acrylic resins can cause a range of skin problems, including allergic contact dermatitis, irritant contact dermatitis, and contact urticaria.

In 1998, Björkner1 published a classification of acrylic resins that is widely accepted and with which we concur. That classification includes monoacrylates, monomethacrylates, multifunctional acrylates, prepolymers, acrylonitrile, acrylamide and derivatives, and cyanoacrylates.

Multifunctional acrylates are used for dental and orthopedic prostheses, glues, adhesives, varnishes, artificial nails, dyes and inks, printing plates, parquet and wood flooring, and sealants for the automotive and iron and steel industries (Loctite, Threebond, and Sta-Lok).

The most important multifunctional acrylates in terms of frequency of sensitization are as follows: hydroxyethyl methacrylate (HEMA), hydroxypropyl methacrylate (HPMA), etyleneglycol dimethacrylate (EGDMA), diethylene glycol dimethacrylate (DEGDMA), trimethylolpropane triacrylate (TMPTMA), triethylene glycol dimethacrylate (TREGDMA), and butanediol dimethacrylate (BUDMA).

We report 4 cases of eczematous allergic contact dermatitis in workers employed in the same company. The dermatitis, which affected both hands, was the result of sensitization to acrylic resins contained in a sealant called Threebond (Fig. 1).

Figure 1.

Threebond sealant responsible for allergic contact dermatitis in our patients, 1 of whom had a vesicular reaction to the 2% Threebond solution.

(0.27MB).

In October 2009 our skin allergy unit was asked to perform a study of 4 patients who worked in the same motorcycle assembly company. The clinical appearance of the palms and between the fingers of both hands was identical in all 4 patients, with extremely pruritic lesions consisting of long-standing vesicles and blisters. The patients obtained sick leave from work and received standard treatment with antihistamines and corticosteroids (topical for 3 patients and oral for 1 patient). The lesions became cracked and scaly and eventually healed. On returning to work, 3 of the patients experienced immediate relapses (the fourth patient had changed jobs). The 4 patients had been in contact with oils and greases, and also with the Threebond sealant resin, which the patients themselves attributed as the cause of their dermatitis. Although the use of special protective gloves, made of thick cloth, was mandatory in the company, all 4 patients admitted that they had occasionally failed to use them.

The 3 patients who experienced a relapse were 35, 40, and 32 years old, and their lesions had developed within 1.5 months, 1 year, and 10 months, respectively, of starting to work with the sealant. As mentioned above, the fourth patient had changed jobs, and so was not included in our study.

The 3 patients underwent patch testing using the following series: the standard Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) battery; the Chemotechnique PG-1000 plastics and glues series and MA-1000 (meth)acrylates series (Chemotechnique Diagnostics AB, Vellinge, Sweden); and the Threebond sealant in 2%, 0.5%, and 0.2% aqueous solutions.

For all 3 patients, readings at 48 and 96hours were negative for allergens in the GEIDAC battery and in the plastics and glues series. As for the (meta)acrylates series, all 3 patients were positive for HEMA, HPMA, and EGDMA, as well as for the 3 concentrations of Threebond; 1 patient was also positive for TREGDMA.

The literature contains a number of reports of allergic contact dermatitis developing following contact with acrylic resins in the Threebond sealant, presenting with eczema in the acute phase.2–5 In 2000, Turker and Beck6 published the results of their study performed between 1983 and 1995, reporting 15% positivity to (meth)acrylates. Of the positive cases, 71% were due to occupational contact: 34% in odontostomatology (dentists, clinical assistants, and dental technicians), and the remaining 66% in other professions.

To avoid sensitization and burns during patch testing, it is important to adequately dilute the sealant before applying the corresponding patch.7

In summary, our 4 patients, workers employed in the same company, had eczematous allergic contact dermatitis on both hands caused by sensitization to acrylic resins contained in the Threebond sealant. The lesions would probably have been avoided had the patients assiduously worn the gloves provided by the company. This underlines the need, in certain occupations, to ensure absolute compliance with all protective measures aimed at preventing direct or airborne contact of the skin with possible allergens or irritants.A number of other cases of dermatitis caused by the same material have been reported in Spain for other occupations.8–10

References
[1]
B. Björkner.
Resinas acrílicas.
Symposium Internacional De Dermatología Labora. Vol 9, pp. 58-66
[2]
C. Romaguera, L. Conde Salazar, F. Grimalt.
Dermatitis de contacto por resinas y plásticos, 2a ed., pp. 195-229
[3]
C. Romaguera, L. Conde Salazar.
Plásticos y resinas sintéticas.
Tratado de Dermatosis, Profesionales, 1a ed., pp. 184-224
[4]
L. Conde Salazar, C. Romaguera.
Dermatitis por plásticos.
Dermatitis de Contacto., pp. 245-281
[5]
L. Conde Salazar, A. Ancona.
Dermatosis profesionales por plásticos y resinas.
Dermatosis Profesionales, pp. 89-110
[6]
S.C. Tucker, M.H.A. Beck.
A 15years study of patch-testing to meth(acrylates) in dental personel.
Contact Dermatitis, 42 (2000), pp. 175-176
[7]
J. Vozmediano, A. Manrique.
Active sensitization to (meth)acrylates.
Contact Dermatitis, 39 (1998), pp. 314
[8]
J.L. Pérez-Formoso, J. de Anca-Fernández, R. Maraví-Cecilia, J.M. Díaz-Torres.
Dermatitis de contacto a acrilatos en una industria de fabricación de ascensores. A propósito de 8 casos.
Actas Dermosifiliogr, 101 (2010), pp. 336-340
[9]
E. Roche, J. de la Cuadra, V. Alegre.
Sensibilización a acrilatos por uñas artificiales acrílicas. Revisión de 15 casos.
Actas Dermosifiliogr, 99 (2008), pp. 788-794
[10]
L. Conde Salazar, L. Romero, D. Guimeraens, M.A. González.
Dermatitis alérgica de contacto por acrilatos en odontólogo y protésico dental.
Actas Dermosifiliogr, 23 (1988), pp. 45-49

Please cite this article as: Romaguera C, et al. Dermatitis de contacto profesional por Threebond©. Cuatro casos en la misma empresa. Actas Dermosifiliogr.2011;102:468-469.

Copyright © 2010. Elsevier España, S.L. and AEDV
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