Información de la revista
Vol. 112. Núm. 9.
Páginas 845-846 (Octubre 2021)
Vol. 112. Núm. 9.
Páginas 845-846 (Octubre 2021)
Images in Dermatology
Open Access
Noonan Syndrome With Multiple Lentigines: Subtle Key Skin Clues to the Diagnosis
Síndrome de Noonan con lentiginosis: manifestaciones dermatológicas sutiles y claves
Visitas
3216
B. Lozano-Masdemonta,
Autor para correspondencia
belenmasdemont@gmail.com

Corresponding author.
, J. Rojas-Calvab, M.T. Darnaude-Ortizc
a Servicio de Dermatología, Hospital Universitario de Móstoles, Madrid, Spain
b Universidad Rey Juan Carlos, Madrid, Spain
c Servicio de Genética, Hospital Universitario de Móstoles, Madrid, Spain
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (1)
Texto completo

A 15-year-old woman was evaluated for generalized redness and roughness of the skin that had been present since childhood. She had congenital pulmonary valve stenosis, incomplete pyeloureteral duplication of the right kidney, and learning difficulties. Physical examination revealed multiple lentigines on the face and neck, about 100 melanocytic nevi, 4 nevus spilus-like spots, a depressed nasal bridge, and a broad philtrum (Fig. 1). Other notable findings included short stature; sparse eyebrows; follicular hyperkeratosis of the face, arms, and thighs; curly hair; and phototype IV. Family members did not present any diseases of interest and shared none of the aforementioned findings. A genetic study found that the patient was heterozygous for the c.1403 C>T (p.Thr486Met) mutation in PTPN11, which is associated with Noonan syndrome with multiple lentigines (formerly known as LEOPARD syndrome).

Figure 1.

Clinical image showing multiple lentigines, keratosis pilaris, sparse eyebrows, a broad nasal philtrum, bulbous nose, and curly hair.

(0,47MB).

Bessis et al1 prospectively collected data on skin alterations in 34 patients genetically diagnosed with Noonan syndrome with multiple lentigines. In addition to those described in our patient, the following signs can be observed: café noir spots, alopecia, temporary alopecia, ulerythema ophryogenes, palmoplantar hyperkeratosis, skin hypermobility, redundant skin in acral regions, ecchymosis, hyperhidrosis, and lymphedema.

Funding

This work has not received any type of funding.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Reference
[1]
D. Bessis, J. Miquel, E. Bourrat, C. Chiaverini, F. Morice-Picard, C. Abadie, et al.
Dermatological manifestations in Noonan syndrome: a prospective multicentric study of 129 patients positive for mutation.
Br J Dermatol., 180 (2019), pp. 1438-1448

Please cite this article as: Lozano-Masdemont B, Rojas-Calva J, Darnaude-Ortiz MT. Síndrome de Noonan con lentiginosis: manifestaciones dermatológicas sutiles y claves. Actas Dermosifiliogr. 2021;112:845–846.

Idiomas
Actas Dermo-Sifiliográficas
Opciones de artículo
Herramientas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?