Graying is a natural process, characterized by the loss of pigment in the hair, and is considered a sign of aging in society; its onset and progression is closely correlated with age and occurs to varying degrees in all individuals, regardless of gender or race. However, premature graying has a psychological and social impact, affecting patients' self-esteem. The exact etiopathogenesis is still unknown, and it has been associated with multiple factors such as: oxidative stress, ultraviolet radiation, genetic factors, and lifestyle factors such as smoking, nutritional and emotional factors. All of this causes a decrease in the production of melanin by the melanocytes of the hair bulb. Despite the extensive molecular research being carried out to understand the pathogenesis of graying, there is a shortage of effective, evidence-based treatment options. Today, graying has become a cultural phenomenon, where many people opt for cosmetic treatments to cover gray hair.