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Vol. 107. Issue 7.
Pages e47-e56 Pages 545-624 (September 2016)
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Vol. 107. Issue 7.
Pages e47-e56 Pages 545-624 (September 2016)
Original
DOI: 10.1016/j.adengl.2016.04.001
The Cost of Psoriasis and Psoriatic Arthritis in 5 European Countries: A Systematic Review
Coste de la psoriasis y artritis psoriásica en cinco países de Europa: una revisión sistemática
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R. Burgos-Pola,
Corresponding author
rburgos@porib.com

Corresponding author.
, J.M. Martínez-Sesmerob, J.M. Ventura-Cerdác, I. Elíasa, M.T. Calotod, M.Á. Casadoa
a Pharmacoeconomics & Outcomes Research Iberia (PORIB), Madrid, Spain
b Servicio de Farmacia, Complejo Hospitalario de Toledo, Toledo, Spain
c Servicio de Farmacia, Hospital Universitario Doctor Peset, Valencia, Spain
d Celgene, S.L, Madrid, Spain
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Tables (5)
Table 1. Characteristics of the Studies Analyzing the Cost of Psoriasis.
Table 2. Characteristics of the Studies Analyzing the Cost of Psoriatic Arthritis.
Table 3. Results of the Evaluation According to the CHEERS List of Recommendationsa
Table 4. Cost of Psoriasis.
Table 5. Cost of Psoriatic Arthritis.
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Additional material (1)
Abstract
Introduction

While the introduction of biologics has improved the quality of life of patients with psoriasis and psoriatic arthritis, it may have increased the economic burden of these diseases.

Objective

To perform a systematic review of studies on the costs associated with managing and treating psoriasis and psoriatic arthritis in 5 European countries: Germany, Spain, France, Italy, and the United Kingdom.

Methods

We undertook a systematic review of the literature (up to May 2015) using the MEDLINE and EMBASE databases. The methodological quality of the studies identified was evaluated using the Consolidated Health Economic Evaluation Reporting Standards checklist. We considered both direct costs (medical and nonmedical) and indirect costs, adjusted for country-specific inflation and converted to international dollars using purchasing power parity exchange rates for 2015 ($US PPP).

Results

The search retrieved 775 studies; 68.3% analyzed psoriasis and 31.7% analyzed psoriatic arthritis. The total annual cost per patient ranged from US $2,077 to US $13,132 PPP for psoriasis and from US $10,924 to US $17,050 PPP for psoriatic arthritis. Direct costs were the largest component of total expenditure in both diseases. The severity of these diseases was associated with higher costs. The introduction of biologics led to a 3-fold to 5-fold increase in direct costs, and consequently to an increase in total costs.

Conclusions

We have analyzed the economic burden of psoriasis and psoriatic arthritis and shown that costs increase with the treatment and management of more severe disease and the use of biologics.

Keywords:
Psoriasis
Psoriatic arthritis
Cost of disease
Review
Germany
Spain
France
Italy
United Kingdom
Resumen
Introducción

La introducción de las terapias biológicas ha mejorado la calidad de vida de los pacientes con psoriasis y artritis psoriásica, aunque podría haber incrementado su carga económica.

Objetivo: Revisar los estudios de costes del manejo de la psoriasis y artritis psoriásica en cinco países de Europa (Alemania, España, Francia, Italia y Reino Unido).

Métodos

Revisión sistemática de la literatura en Medline y Embase hasta mayo 2015. La calidad metodológica de las publicaciones se evaluó mediante las recomendaciones de la Consolidated Health Economics Reporting Standard (CHEERS). Se consideraron costes directos (sanitarios y no sanitarios) e indirectos, actualizados por la inflación de cada país y ajustados a dólares internacionales 2015 mediante la Paridad de Capacidad Adquisitiva (USD-PPP).

Resultados

Se identificaron 775 publicaciones, 68,3% de psoriasis y 31,7% de artritis psoriásica. El coste total anual por paciente osciló entre 2.077-13.132 USD-PPP y 10.924-17.050 USD-PPP en psoriasis y artritis psoriásica, respectivamente. En ambas patologías, la partida con mayor contribución al coste total fue la relacionada con costes directos. Estadios más graves de la enfermedad se asociaron con un aumento de costes. La introducción de terapias biológicas conllevó un incremento de 3 a 5 veces de los costes directos, que repercutió en los costes totales.

Conclusiones

Esta revisión pone de manifiesto el impacto económico que supone el tratamiento y manejo de la psoriasis y artritis psoriásica, el cual aumenta en función de la gravedad del paciente y de la inclusión de terapias biológicas.

Palabras clave:
Psoriasis
Artritis psoriásica
Coste de la enfermedad
Revisión
Alemania
España
Francia
Italia
Reino Unido

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