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Vol. 107. Num. 10.
Pages 799-878 (December 2016)
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Vol. 107. Num. 10.
Pages 799-878 (December 2016)
Advances in Dermatology
DOI: 10.1016/j.adengl.2016.05.025
Kidney Disease and Psoriasis. A New Comorbidity?
Enfermedad renal y psoriasis. ¿Una nueva comorbilidad?
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E. González-Parraa, E. Daudénb, J.M. Carrascosac, A. Olveirad, R. Botellaf, C. Bonanadg, R. Riverae,
Corresponding author
rriveradiaz@hotmail.com

Corresponding author.
, for the Systemic Inflammation in Psoriasis Working Group
a Servicio de Nefrología, Hospital La Fundación Jiménez Díaz, Madrid, Spain
b Servicio de Dermatología, Hospital La Princesa, Madrid, Spain
c Servicio de Dermatologia, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
d Servicio de Aparato Digestivo, Hospital La Paz, Madrid, Spain
e Servicio de Dermatología, Hospital 12 de Octubre, Madrid, Spain
f Servicio de Dermatología, Hospital Universitario La Fe, Valencia, Spain
g Servicio de Cardiología, Hospital Clínico Universitario, Valencia, Spain
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Tables (3)
Table 1. Hazard Ratio for Chronic Kidney Disease (CKD) and End Stage Renal Disease (ESRD) in Patients With Psoriasis in Two Cohort Studies.
Table 2. Recommendations for Preventing Renal Damage in Patients with Psoriasis.
Table 3. Psoriasis and Kidney Disease: Key Messages.
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Abstract

Psoriasis is a chronic inflammatory disease that has been associated with cardiovascular and metabolic comorbidities, particularly in young patients and patients with more severe forms of the disease. Recent studies have also linked psoriasis to kidney disease, and this would seem only logical, as the kidney is both a target of classic cardiovascular risk factors and susceptible to the toxic effects of some of the traditional drugs used to control psoriasis.

In this article, we would like to draw readers’ attention to this recently described comorbidity and stress the importance of early detection, as once chronic kidney disease develops, it cannot be reversed. When evaluating patients with psoriasis, particularly when they are candidates for systemic therapy, we believe it is important to order laboratory tests including glomerular filtration rate and a simple urine test to screen for albuminuria (albumin/creatinine ratio).

Keywords:
Psoriasis
Kidney disease
Comorbidity
Resumen

La psoriasis es un proceso inflamatorio crónico que se ha asociado con comorbilidades cardiovasculares y metabólicas, especialmente las formas más graves y en pacientes jóvenes. Estudios recientes relacionan también la psoriasis con enfermedad renal, y parece lógico que sea así porque, por un lado, el riñón es un órgano diana de los factores de riesgo cardiovascular clásicos, y además, algunos de los tratamientos clásicos empleados para controlar la psoriasis tienen toxicidad renal. Con este artículo queremos hacer una llamada de atención sobre esta comorbilidad recientemente descrita; es fundamental su detección precoz porque una vez instaurada, la enfermedad renal crónica es irreversible. Consideramos importante que en el estudio basal de todo paciente con psoriasis, especialmente aquellos que van a recibir terapia sistémica, se analice la función renal con una analítica de sangre con filtrado glomerular y un análisis sencillo de orina para estudiar la albuminuria (relación albúmina/creatinina).

Palabras clave:
Psoriasis
Enfermedad renal
Comorbilidad

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