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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Granular cell tumor &#40;GCT&#41;&#44; also known as Abrikossoff tumor&#44; is an uncommon benign neoplasm&#44; probably of neural origin derived from Schwann cells&#46; It presents clinically as a solitary asymptomatic nodule and its pathogenesis has been the subject of much debate in the literature&#46;</p> <span class="elsevierStyleSectionTitle">Objectives</span><p class="elsevierStyleSimplePara elsevierViewall">We aimed to analyze the clinical&#44; histologic&#44; and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">In this retrospective study of 34 patients with histologic diagnosis of GCT&#44; we analyzed clinical characteristics &#40;site&#44; age&#44; sex&#44; duration&#44; and suspected diagnosis&#41;&#44; histological findings &#40;border&#44; cell atypia and mitoses&#44; involvement of adnexal structures&#44; pseudoepitheliomatous hyperplasia&#44; and presence of the recently described pustulo-ovoid bodies&#41;&#44; and immunohistochemical findings &#40;S-100 staining in 16 randomly selected cases&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">In total&#44; 58&#46;82&#37; were men and 41&#46;18&#37; were women&#44; and the mean age was 31&#46;74 years&#46; The most common site was the oral cavity &#40;61&#46;76&#37;&#41;&#46; The most frequently suspected clinical diagnosis was fibroma &#40;17&#46;65&#37;&#41;&#46; The lesion was poorly defined and diffuse in 85&#46;29&#37;&#46; Pseudoepitheliomatous hyperplasia was present in 58&#46;82&#37;&#46; Nuclear atypia was found in 29&#46;41&#37; and mitoses in 20&#46;59&#37;&#46; One case was considered malignant &#40;2&#46;94&#37;&#41; and 2 atypical &#40;5&#46;88&#37;&#41;&#46; Pustulo-ovoid bodies were present in 47&#46;06&#37; of the cases and S-100 staining was positive in all cases analyzed&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Our series confirms the characteristics described previously for GCT&#44; except for certain peculiarities&#44; and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El tumor de c&#233;lulas granulares cut&#225;neo &#40;TCG&#41; o de Abrikossoff es una neoplasia benigna e infrecuente&#44; probablemente de origen neural a partir de las c&#233;lulas de Schwann&#46; Cl&#237;nicamente se manifiesta como un n&#243;dulo solitario y asintom&#225;tico&#44; y su etiopatogenia ha estado ampliamente debatida en la literatura&#46;</p> <span class="elsevierStyleSectionTitle">Objetivos</span><p class="elsevierStyleSimplePara elsevierViewall">Analizar las caracter&#237;sticas cl&#237;nicas&#44; histol&#243;gicas e inmunohistoqu&#237;micas asociadas a este tumor y determinar si estos hallazgos se corresponden con lo descrito hasta el momento en la literatura&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realiza un estudio retrospectivo de treinta y cuatro casos con diagn&#243;stico histol&#243;gico de TCG don-de se analizan las caracter&#237;sticas cl&#237;nicas &#40;localizaci&#243;n&#44; edad&#44; sexo&#44; tiempo de evoluci&#243;n y sospecha diagn&#243;stica&#41;&#44;histol&#243;gicas &#40;delimitaci&#243;n&#44; atipia&#44; mitosis&#44; afectaci&#243;n de anejos cut&#225;neos&#44; hiperplasia seudoepiteliomatosa y presencia de los recientemente descritos cuerpos p&#250;stulo-ovoides &#91;CPO&#93;&#41; e inmunohistoqu&#237;micas &#40;tinci&#243;n S-100 en 16 casos seleccionados aleatoriamente&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">El 58&#44;82&#37; fueron hombres y el 41&#44;18&#37; mujeres&#46; La edad media fue de 31&#44;74 a&#241;os&#46; La localizaci&#243;n m&#225;s frecuente fue la cavidad oral &#40;61&#44;76&#37;&#41;&#46; El diagn&#243;stico cl&#237;nico m&#225;s com&#250;nmente sospechado fue el de fibroma &#40;17&#44;65&#37;&#41;&#46; En un 85&#44;29&#37; se presentaba como una lesi&#243;n mal delimitada y difusa&#46; La hiperplasia seudoepiteliomatosa estuvo presente en el 58&#44;82&#37;&#46; Se encontraron atipias nucleares en el 29&#44;41&#37; y mitosis en un 20&#44;59&#37;&#46; Hubo un caso maligno &#40;2&#44;94&#37;&#41; y dos se consideraron at&#237;picos &#40;5&#44;88&#37;&#41;&#46; Los CPO estuvieron presentes en el 47&#44;06&#37;&#46; La tinci&#243;n con S-100 fue positiva en el 100&#37; de los casos analizados&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Nuestra serie confirmar&#237;a las caracter&#237;sticas descritas hasta el momento para el TCG salvo con algunas peculiaridades y apoyar&#237;a la existencia de los CPO como un nuevo hallazgo histol&#243;gico adicional parael diagn&#243;stico de este tumor&#46;</p>"
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Vol. 100. Issue 2.
Pages 126-132 (March 2009)
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Vol. 100. Issue 2.
Pages 126-132 (March 2009)
Original article
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Cutaneous Granular Cell Tumor: A Clinical and Pathologic Analysis of 34 Cases
Tumor de Células Granulares Cutáneo: Análisis Clínico-Patológico de Treinta y Cuatro Casos
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A. Torrijos-Aguilar
Corresponding author
zazu1710@hotmail.com

Correspondence: C/ Bordellet 6, pta. 7, 46113 Moncada, Valencia, Spain.
, V. Alegre-de Miquel, G. Pitarch-Bort, P. Mercader-García, J.M. Fortea-Baixauli
Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Spain
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Abstract
Background

Granular cell tumor (GCT), also known as Abrikossoff tumor, is an uncommon benign neoplasm, probably of neural origin derived from Schwann cells. It presents clinically as a solitary asymptomatic nodule and its pathogenesis has been the subject of much debate in the literature.

Objectives

We aimed to analyze the clinical, histologic, and immunohistochemical characteristics associated with this tumor and to determine whether these findings correspond to those reported to date in the literature.

Methods

In this retrospective study of 34 patients with histologic diagnosis of GCT, we analyzed clinical characteristics (site, age, sex, duration, and suspected diagnosis), histological findings (border, cell atypia and mitoses, involvement of adnexal structures, pseudoepitheliomatous hyperplasia, and presence of the recently described pustulo-ovoid bodies), and immunohistochemical findings (S-100 staining in 16 randomly selected cases).

Results

In total, 58.82% were men and 41.18% were women, and the mean age was 31.74 years. The most common site was the oral cavity (61.76%). The most frequently suspected clinical diagnosis was fibroma (17.65%). The lesion was poorly defined and diffuse in 85.29%. Pseudoepitheliomatous hyperplasia was present in 58.82%. Nuclear atypia was found in 29.41% and mitoses in 20.59%. One case was considered malignant (2.94%) and 2 atypical (5.88%). Pustulo-ovoid bodies were present in 47.06% of the cases and S-100 staining was positive in all cases analyzed.

Conclusions

Our series confirms the characteristics described previously for GCT, except for certain peculiarities, and supports the presence of pustulo-ovoid bodies as an additional histologic finding for diagnosis of this tumor.

Key words:
granular cell tumor
Abrikossoff tumor
pustulo-ovoid bodies of Milian
Resumen
Introducción

El tumor de células granulares cutáneo (TCG) o de Abrikossoff es una neoplasia benigna e infrecuente, probablemente de origen neural a partir de las células de Schwann. Clínicamente se manifiesta como un nódulo solitario y asintomático, y su etiopatogenia ha estado ampliamente debatida en la literatura.

Objetivos

Analizar las características clínicas, histológicas e inmunohistoquímicas asociadas a este tumor y determinar si estos hallazgos se corresponden con lo descrito hasta el momento en la literatura.

Métodos

Se realiza un estudio retrospectivo de treinta y cuatro casos con diagnóstico histológico de TCG don-de se analizan las características clínicas (localización, edad, sexo, tiempo de evolución y sospecha diagnóstica),histológicas (delimitación, atipia, mitosis, afectación de anejos cutáneos, hiperplasia seudoepiteliomatosa y presencia de los recientemente descritos cuerpos pústulo-ovoides [CPO]) e inmunohistoquímicas (tinción S-100 en 16 casos seleccionados aleatoriamente).

Resultados

El 58,82% fueron hombres y el 41,18% mujeres. La edad media fue de 31,74 años. La localización más frecuente fue la cavidad oral (61,76%). El diagnóstico clínico más comúnmente sospechado fue el de fibroma (17,65%). En un 85,29% se presentaba como una lesión mal delimitada y difusa. La hiperplasia seudoepiteliomatosa estuvo presente en el 58,82%. Se encontraron atipias nucleares en el 29,41% y mitosis en un 20,59%. Hubo un caso maligno (2,94%) y dos se consideraron atípicos (5,88%). Los CPO estuvieron presentes en el 47,06%. La tinción con S-100 fue positiva en el 100% de los casos analizados.

Conclusiones

Nuestra serie confirmaría las características descritas hasta el momento para el TCG salvo con algunas peculiaridades y apoyaría la existencia de los CPO como un nuevo hallazgo histológico adicional parael diagnóstico de este tumor.

Palabras clave:
tumor de células granulares
tumor de Abrikossoff
cuerpos pústulo-ovoides de Milian
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Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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