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Vol. 109. Issue 8.
Pages 699-707 (October 2018)
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Vol. 109. Issue 8.
Pages 699-707 (October 2018)
Practical Dermatology
DOI: 10.1016/j.adengl.2018.07.010
Cutaneous Adverse Drug Reactions: How to Identify the Trigger
Reacciones cutáneas adversas a medicamentos: cómo identificar el desencadenante
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A. Zambernardi
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ma.zambernardi@gmail.com

Corresponding author.
, M. Label
Servicio de Dermatología, Hospital Ramos Mejía, Ciudad de Buenos Aires, Argentina
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Abstract

It is estimated that 10% to 15% of medicated patients develop adverse drug reactions (ADR). Despite the high prevalence of ADR, the identification of the trigger drugs remains a medical challenge, mainly in polymedicated patients. Our goal is to update the diagnostic tools to identify enhancer drugs of type B-ADR that compromise the skin and/or mucous membranes, in order to optimize patients’ follow-up and improve their quality of life. We develop the review in two stages: I- we review the pathophysiological mechanisms of the ADR; II- we developed the clinical approach for the identification of the triggering drug.

Keywords:
Adverse drug reactions
Drug-induced skin disorders
Diagnostic methods
Pharmacological Interaction of Drugs With Immune Receptors (P-i CONCEPT)
Pseudoallergies
Hypersensitivity reactions
Resumen

Entre el 10 al 15% de los pacientes medicados desarrollan reacciones adversas a medicamentos (RAM). A pesar de la alta prevalencia de RAM, la identificación del agente causal es un desafío diagnóstico y terapéutico, principalmente en pacientes que reciben múltiples medicamentos. Nuestro objetivo es actualizar los métodos de diagnóstico para identificar el fármaco desencadenante de RAM de tipo B que comprometa piel y/o mucosas, a fin de optimizar el seguimiento y la calidad de vida del paciente. Desarrollamos la revisión en dos etapas: I- repasamos los mecanismos fisiopatológicos de las RAM; II- desarrollamos el abordaje clínico para la identificación del desencadenante.

Palabras clave:
Reacciones adversas a medicamentos
Farmacodermias
Métodos de diagnósticos
Interacción farmacológica de medicamentos con receptores inmunes (CONCEPTO P-I)
Pseudoalergias
Reacciones de hipersensibilidad

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