Publish in this journal
Journal Information
Vol. 109. Num. 7.September 2018
Pages e1-e10Pages 577-666
Download PDF
More article options
Vol. 109. Num. 7.September 2018
Pages e1-e10Pages 577-666
Special article
DOI: 10.1016/j.adengl.2018.06.020
Prevention and treatment of tuberculosis infection in candidates for biologic therapy: A multidisciplinary consensus statement adapted to the dermatology patient
Consenso multidisciplinar sobre prevención y tratamiento de la tuberculosis en pacientes candidatos a tratamiento biológico. Adaptación al paciente dermatológico
P. Rodríguez-Jiméneza,
Corresponding author
, I. Mir-Viladrichb, P. Chicharroa, G. Solano-Lópeza, F.J. López-Longoc, C. Taxonerad, P. Sánchez-Martíneze, X. Martínez-Lacasaf, M. García-Gasallag, J. Dorcah, M. Arias-Guilléni, J.M. García-Garcíaj, E. Daudena
a Servicio de Dermatología, IIS-FIB, Hospital Universitario de La Princesa. Madrid, España
b Servicio de Neumología, Hospital Son Llàtzer, Palma de Mallorca, España
c Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, España
d Servicio del Aparato Digestivo, Hospital Clínico San Carlos e Instituto de Investigación del Hospital Clínico San Carlos (IdISSC), Madrid, España
e Servicio de Enfermedades Infecciosas, Hospital del Mar, Barcelona, España
f Unidad Control de Tuberculosis, Hospital Universitari Mutua de Terrassa, Barcelona, España
g Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Son Llàtzer, Palma de Mallorca, España
h Servicio de Neumología, Hospital Universitario de Bellvitge, Hospitalet de Llobregat (Barcelona), España
i Servicio de Neumología, Hospital Universitario Central de Asturias-Instituto Nacional de Silicosis, Oviedo, España
j Servicio de Neumología, Hospital San Agustín, Avilés, España
This item has received
Article information
Full Text
Download PDF
Figures (4)
Show moreShow less
Tables (8)
Table 1. Degree of Recommendation18
Table 2. Type of Biological Agent, Indication, and Date of Approval.
Table 3. Immunosuppressants That May Induce Tuberculosis.
Table 4. Incidence and Relative Risk of Tuberculosis in Rheumatoid Arthritis Before and After Introduction of Anti-TNF Agents: Impact of the Recommendations.
Table 5. Groups at High Risk of Conversion to Active Tuberculosis.
Table 6. Results of Screening Tests for Latent Tuberculosis Infection in Patients with Systemic Inflammatory Diseases.
Table 7. Interpretation of the Results of Screening in Immunosuppressed Patients.
Table 8. Final Recommendations with Degree of Evidence.
Show moreShow less

Patients with chronic inflammatory diseases being treated with immunosuppressive drugs, and with tumor necrosis factor inhibitors in particular, have an increased risk of infection by Mycobacterium tuberculosis. Screening for latent tuberculosis infection and preventive therapy to reduce the risk of progression to active tuberculosis are mandatory in this group of patients. This updated multidisciplinary consensus document presents the latest expert opinions on the treatment and prevention of tuberculosis in candidates for biologic therapy and establishes recommendations based on current knowledge relating to the use of biologic agents.

Hidradenitis suppurativa
Biologic therapy

El riesgo de infección por Mycobacterium tuberculosis se halla aumentado en los pacientes con enfermedades inflamatorias crónicas y en tratamiento inmunosupresor, en particular con terapia antifactor de necrosis tumoral α. La detección de la infección tuberculosa latente y el tratamiento preventivo dirigido a reducir el riesgo de progresión a tuberculosis activa es obligatoria en este grupo de pacientes. Este documento de consenso multidisciplinar actualiza la opinión de expertos y establece recomendaciones para el diagnóstico y tratamiento de la infección tuberculosa latente en estos pacientes, según los conocimientos actuales en terapias biológicas.

Palabras clave:
Hidrosadenitis supurativa
Terapias biológicas


These are the options to access the full texts of the publication Actas Dermo-Sifiliográficas (English Edition)
If you are a member of the AEDV:
Go to the members area of the website of the AEDV, ( and login.

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe to

Actas Dermo-Sifiliográficas (English Edition)

From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
902 88 87 40
Calls from outside Spain
+34 932 418 800
Actas Dermo-Sifiliográficas (English Edition)

Subscribe to our Newsletter

Article options
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

es en
Política de cookies Cookies policy
Utilizamos cookies propias y de terceros para mejorar nuestros servicios y mostrarle publicidad relacionada con sus preferencias mediante el análisis de sus hábitos de navegación. Si continua navegando, consideramos que acepta su uso. Puede cambiar la configuración u obtener más información aquí. To improve our services and products, we use "cookies" (own or third parties authorized) to show advertising related to client preferences through the analyses of navigation customer behavior. Continuing navigation will be considered as acceptance of this use. You can change the settings or obtain more information by clicking here.