Subacute cutaneous lupus erythematosus—like drug eruption due to combination diuretic hydrochlorothiazide and triamterene

https://doi.org/10.1016/S0190-9622(88)70005-5Get rights and content

Three patients taking a frequently prescribed diuretic combination of hydrochlorothiazide and triamterene developed eruptions resembling subacute cutaneous lupus erythematosus. Histopathology of the skin biopsies of all three patients was consistent with subacute cutaneous lupus erythematosus. On discontinuation of the diuretic drug, the cutaneous eruptions cleared.

References (22)

  • P Baume et al.

    Triamterene, a new natriuretic agent

    Am J Med Sci

    (1963)
  • Cited by (43)

    • What Dermatologists Should Know About Thiazides

      2022, Actas Dermo-Sifiliograficas
    • The spectrum of nephrocutaneous diseases and associations: Inflammatory and medication-related nephrocutaneous associations

      2016, Journal of the American Academy of Dermatology
      Citation Excerpt :

      Notable drug-specific reactions include vesiculobullous eruptions and pustular lesions caused by furosemide and alopecia caused by amiloride and hydrochlorothiazide. Table II provides a comprehensive list of cutaneous side effects of common diuretic agents.40-95 The overall incidence of adverse reactions to ACE inhibitors is estimated at 28%, half of which are cutaneous in nature.96

    • Photosensitivity due to thiazides

      2014, Actas Dermo-Sifiliograficas
      Citation Excerpt :

      Scaly, erythematous plaques that are clinically and histologically indistinguishable from idiopathic SCLE. In addition, anti-Ro/SS-A and anti-La/SS-B antinuclear antibodies may be present in the serum and immune complex deposition may be present in the basement membrane.10,13–18 Lichenoid reaction.

    View all citing articles on Scopus
    View full text