Eosinophilic spongiosis: A clinicopathologic review of seventy-one cases

doi:10.1016/S0190-9622(83)70036-8

Journal of the American Academy of Dermatology

Volume 8, Issue 3, March 1983, Pages 337-343

https://doi.org/10.1016/S0190-9622(83)70036-8 Get rights and content

Eosinophilic spongiosis has a distinctive but not diagnostic histologic pattern of the epidermis. This pattern may be seen in a wide variety of clinical disorders. We have observed it most commonly in bullous pemphigoid, particularly the urticarial stage. In most biopsy specimens that show eosinophilic spongiosis, additional definable histologic criteria allow a specific clinical diagnosis to be made. Rarely, clinical correlation and inlmunofluorescent data may be needed for a precise diagnosis. The location of eosinophilic spongiosis within the epidermis is generally not helpful in making a definite diagnosis. The peripheral eosinophilia, found in 61% and 46% of our pemphigoid and pemphigus cases, respectively, may be an important laboratory parameter in the evolution of this distinctive histologic pattern. Eosinophilic spongiosis occurs in early pemphigus lesions. However, its presence does not necessarily herald pemphigus, as a similar histologic pattern can be seen in pemphigoid and other disorders.

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Eosinophilic spongiosis: A clinicopathologic review of seventy-one cases

Pemphigus foliaceus

Arch Dermatol

Eosinophilic spongiosis in pemphigus: A report of an unusual histological change in pemphigus

Arch Dermatol

Eosinophilic spongiosis in early pemphigus foliaceus

Acta Derm Venereol (Stockh)

Childhood pemphigus initially seen as eosinophilic spongiosis

Arch Dermatol

Pemphigus foliaceus: Early clinical appearance as dermatitis herpetiformis with eosinophilic spongiosis

Arch Dermatol

Pemphigus vegetans: Its relationship to eosinophilic spongiosis and favorable response to dapsone

Arch Dermatol

Herpetiform pemphigus, a variable pattern of pemphigus

Int J Dermatol

Dermatitis herpetiformis and acantholysis or pemphigus with response to sulfonamides: Report of two cases

Arch Dermatol

Pemphigus herpetiformis

Hautarzt

Acantholytic herpetiform dermatitis

Arch Dermatol

Erythromelanodermie bei “pemphigus herpetiformis” mit eosinophiler Spongiose

Hautarzt