Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Oral and maxillofacial pathologyThe clinical spectrum of Actinomyces-associated lesions of the oral mucosa and jawbones: correlations with histomorphometric analysis
Section snippets
Materials and Methods
The archives of the Institute of Pathology at Rabin Medical Center and the Department of Oral Pathology and Medicine, School of Dental Medicine, Tel-Aviv University, were searched for any biopsies in which Actinomyces colonies were microscopically identified between 1996 and 2005. Only cases with documented clinical, radiographic, and follow-up data were included in the study. Demographic data, details of medical history, clinical presentation, treatment course, and follow-up were retrieved
Study population
A total of 106 patients were included in the study: 48 male and 58 female. The age range was 13-84 years, mean 50.5 years.
Medical status
Forty (37.7%) of the cases were healthy, without any underlying medical condition. Of the 66 patients (62.3%) with a medical background, the most prevalent conditions were cardiovascular diseases (30), nonoral malignancies (29), and diabetes mellitus (13). Other medical conditions in the study population included neurologic diseases (10), respiratory tract diseases (10),
Discussion
Actinomycosis of the jaws and oral tissues has been considered for a long time to be a rare disease, and therefore it did not generate much interest in research. However, in recent years, infection by Actinomyces species has begun to get more attention in the field of oral pathology, especially as a potential complication in BROJ.9, 10, 11, 18 Infection by Actinomyces has also been suggested to be responsible for deterioration in outcome in cases of osteoradionecrosis of the jaws.19, 20, 21, 22
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