MiscellaneousAutoimmune Manifestations of Kikuchi Disease
Section snippets
Methods
This study includes 20 patients who were diagnosed in our hospital with histologically confirmed KD. The “Complexo Hospitalario Universitario of Vigo (CHUVI)” has 1250 beds and attends a population that is half urban and half rural, of more than 600,000 inhabitants.
From January 1990 until December 2010, 13 patients with KD were diagnosed and 12 were followed as outpatients with periodic examinations and autoimmunity studies. In 7 additional cases, the electronic records were reviewed and the
General Characteristics of Patients with KD
During the 20-year period, 20 consecutive patients were diagnosed with KD, 13 women (65%) and 7 men (35%) (ratio of women/men, 1.86:1). The mean age at diagnosis was 29 years (range, 15-79). This was higher in men (44 vs 27 years, P < 0.05). Of the 20 patients, 11 were diagnosed with KD during the hospital stay; 5 were diagnosed as outpatients when they were referred for adenopathy study. In the other 3 previously reported cases (8), the disease started after 2 weeks in the hospital for another
Discussion
KD is a rare entity in Western countries that accounts for 0.77% of diagnosis from lymph node biopsies and for which there are few clinical series with more than 9 patients and a prolonged follow-up time (11, 12). This study includes 20 white patients diagnosed with KD with a long follow-up, 17 of them specifically studied to detect the appearance of autoimmune diseases.
Although the general demographic, clinical, and analytical characteristics of the present series were similar to those
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2021, Molecular and Cellular ProbesCitation Excerpt :There are no specific symptoms or laboratory tests for KFD. Some KFD patients have been misdiagnosed with lymphoma and were overtreated with chemotherapy [9]. This experience causes patients suffering, stress, and impacts their health.
Pediatric Kikuchi-Fujimoto disease: A clinicopathologic study and the therapeutic effects of hydroxychloroquine
2019, Journal of Microbiology, Immunology and InfectionCitation Excerpt :Sopeña et al. conducted a case series with the mean follow-up for 119 months, and revealed 5 (29%) of 17 cases had autoimmune diseases prior to or simultaneously with the KFD diagnosis, and 4 (24%) additional cases thereafter.8 SLE was mostly encountered,3,5,10,24 and others such as Sjögren's syndrome and autoimmune thyroiditis have also been mentioned in several studies.6,8,11 In a literature review of 244 KFD cases, higher ANA positivity rate (23% vs. 3%) and association with SLE (28% vs. 9%) were noted in cases from East Asia and the Far East than in those from Europe.10
Clinical association between Kikuchi׳s disease and systemic lupus erythematosus: A systematic literature review
2017, Seminars in Arthritis and RheumatismCitation Excerpt :Kikuchi׳s disease and SLE share many characteristics, not only histological but also clinical, since both diseases affect young women with greater frequency, and many of the symptoms and laboratory disorders of KD patients are diagnostic criteria for SLE. Anti-nuclear antibodies (ANAs) are positive at the time of diagnosis in 30% of patients with KD [4–7], and several cohorts of KD patients with prolonged follow-up have shown that many of such patients develop SLE over time [4,8]. In addition, the treatments shown to be efficient in KD are the same as those used in SLE, that is, corticosteroids, hydroxychloroquine, intravenous immunoglobulins and, in the most severe cases, rituximab [9–12].
Immune-mediated necrotizing myopathy with concomitant development of Kikuchi–Fujimoto disease
2024, International Journal of Rheumatic DiseasesClinical features and prognosis of 118 children with histiocytic necrotizing lymphadenitis
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The authors have no conflicts of interest to disclose.