Treatment of latent or subclinical Genital HPV Infection with 5-aminolevulinic acid-based photodynamic therapy
Section snippets
Background
There is persuasive evidence that human papillomavirus (HPV) DNA can persist in the epithelium in the absence of a disease, and it has been suggested that latent infections may persist for years or even decades [1]. Persistent HPV infection is the strongest risk factor for developing HPV-associated precancers and cancers [2]. The aim of conventional treatment is to remove warts, which is ineffective for latent, persistent infections. As such, it is common for genital warts to recur after
Aims
To observe the effect of photodynamic therapy in patients with latent or subclinical genital HPV Infection.
Methods
Patients of the Department of Dermatology and Venereology, Nanfang Hospital from February 2016 to December 2017, who had positive test results for HPV and were asymptomatic with no visible lesions, were enrolled. Patients under 18 years old provided informed consent by their guardian. HPV genotype and viral load assay were performed on a female baby with five month old with the consent of her parents. At each patient visit, polymerase chain reaction was used to identify HPV genotypes and
Results
A total of 20 patients (7 males and 13 females) with ages ranging from 5 months to 50 years were enrolled. Their clinical characteristics are presented in Table 1. A total of 15 patients with active infections received ALA-PDT treatment, and HPV viral loads were significantly decreased after three rounds of treatment (p < 0.001). Fourteen of the patients had negative results on HPV tests after three rounds of PDT treatment (14/15, 93.33%). Among them, twelve had negative HPV test results after
Conclusion
In the present study, the results indicated that PDT treatment can effectively eliminate HPV, significantly reducing viral loads after three rounds of treatment (p < 0.001). The rate of negative HPV DNA test results was higher in patients with latent or subclinical infections than in patients with genital warts after one round of PDT treatment, which indicates that latent HPV infections are more easily cleared that symptomatic cases. ALA-PDT can effectively eliminate latent or subclinical HPV
Conflict of interest
All authors have no conflict of interest.
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