Commentary
Becker’s Nevus and Lethal Beta-Actin Mutations

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The etiology of Becker’s nevus and Becker’s nevus syndrome has been until now unknown. Cai et al. provide evidence that these disorders are caused by lethal mutations in ACTB, a gene coding for beta-actin. They hypothesize that these mutations may interfere with Hedgehog pathway signaling. Their findings have important implications for clinical genetics, and they open new aspects in hair research.

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See related article on pg 1795