A retrospective institutional study of the association of smoking with the severity of hidradenitis suppurativa

doi:10.1016/j.jdermsci.2017.04.006

Journal of Dermatological Science

Volume 87, Issue 2, August 2017, Pages 206-207

https://doi.org/10.1016/j.jdermsci.2017.04.006 Get rights and content

Highlights

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Smoking is a modifiable lifestyle factor and a contributing risk factor for HS.
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In our study of 133 patients, current smoking was associated with more extensive HS.
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Smokers had increased risk for more than two body areas affected compared to non-smoking patients with HS.
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Patients should be informed about the effects of smoking in HS and encouraged to quit smoking.

Section snippets

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Conflict of interest disclosure

The authors have no conflict of interest to declare.

References (10)

C. Dessinioti et al.
Hidradenitis suppurativa (acne inversa) as a systemic disease
Clin. Dermatol.
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H. Kurzen et al.
What causes hidradenitis suppurativa?
Exp. Dermatol.
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L. Matusiak et al.
Hidradenitis suppurativa and associated factors: still unsolved problems
J. Am. Acad. Dermatol.
(2009)
F. Canoui-Poitrine et al.
Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity
J. Am. Acad. Dermatol.
(2009)
K. Sartorius et al.
Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity
Br. J. Dermatol.
(2009)

There are more references available in the full text version of this article.

Cited by (21)

Epidemiology of hidradenitis suppurativa
2023, Clinics in Dermatology
Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent skin disease affecting hair follicles in predominantly intertriginous areas, characterized by deep, painful nodules and abscesses, fistulas, sinus tracts, and scarring. The estimated global prevalence of HS is highly variable, as revealed in a growing body of published literature, and ranges from 0.053% to 4.1%. In North American and European patients, HS is three times more common in women than men, whereas in South Korea and Japan, male predominance is found. The disease most frequently manifests itself between the ages of 18 and 29. Numerous published studies have reported the association between smoking, obesity, and HS, although there are limitations in confirming the causal relationship due to the retrospective design of the available studies.
Case-control studies have frequently evaluated the association between HS, metabolic syndrome, and other systemic comorbidities. Due to increased mental health problems, a higher risk of suicide in patients with HS has been reported. We provide up-to-date evidence about the epidemiology, genetic and environmental risk factors, comorbidities, and quality of life of patients with HS. The divergence in HS frequency, possibly due to differences in populations and methodologies, remains to be explained in future worldwide studies.
Lipidomics Profiling of Hidradenitis Suppurativa Skin Lesions Reveals Lipoxygenase Pathway Dysregulation and Accumulation of Proinflammatory Leukotriene B4
2020, Journal of Investigative Dermatology
Citation Excerpt :
Reported prevalence rates of HS vary from 0.03% to 4% of the population, with female predominance (Jemec et al., 1996; Kirsten et al., 2020; Revuz et al., 2008; Vazquez et al., 2013). Obesity, smoking, and mechanical friction are well-established risk factors associated with the development of HS (Dessinioti et al., 2017; Fabbrocini et al., 2016). It has gradually been accepted that HS is an immunologic disease of the hair follicle, immunohistologically characterized by perifollicular inflammation predominantly involving neutrophils and macrophages in the acute phase of the lesion.
Hidradenitis suppurativa (HS) is a chronic, recurring inflammatory dermatosis characterized by abscesses, deep-seated nodules, sinus tracts, and fibrosis in skin lesions around hair follicles of the axillary, inguinal, and anogenital regions. Whereas the exact pathogenesis remains poorly defined, clear evidence suggests that HS is a multifactorial inflammatory disease characterized by innate and adaptive immune components. Bioactive lipids are important regulators of cutaneous homeostasis, inflammation, and resolution of inflammation. Alterations in the lipid mediator profile can lead to malfunction and cutaneous inflammation. We used targeted lipidomics to analyze selected omega-3 and omega-6 polyunsaturated fatty acids in skin of patients with HS and of healthy volunteers. Lesional HS skin displayed enrichment of 5-lipoxygenase (LO)‒derived metabolites, especially leukotriene B4. In addition, 15-LO‒derived metabolites were underrepresented in HS lesions. Changes in the lipid mediator profile were accompanied by transcriptomic dysregulation of the 5-LO and 15-LO pathways. Hyperactivation of the 5-LO pathway in lesional macrophages identified these cells as potential sources of leukotriene B4, which may cause neutrophil influx and activation. Furthermore, leukotriene B4–induced mediators and pathways were elevated in HS lesions, suggesting a contribution of this proinflammatory lipid meditator to the pathophysiology of HS.
Hidradenitis Suppurativa: Estimated Prevalence, Clinical Features, Concomitant Conditions, and Diagnostic Delay in a University Teaching Hospital in Buenos Aires, Argentina
2019, Actas Dermo-Sifiliograficas
La hidradenitis supurativa es una enfermedad sistémica inflamatoria crónica y recurrente, que afecta, principalmente, los grandes pliegues. Se origina por la oclusión de las unidades pilosebáceas, con la consecuente formación de nódulos dolorosos, abscesos, fístulas y cicatrices, con un alto impacto en la calidad de vida.
Describir prevalencia, características clínicas, frecuencia de comorbilidades y latencia diagnóstica, en pacientes con hidradenitis supurativa atendidos en el Hospital Italiano de Buenos Aires.
Estudio retrospectivo descriptivo de corte transversal. Se relevó la información de las historias clínicas electrónicas de todos los pacientes con diagnóstico de hidradenitis supurativa atendidos en el Hospital Italiano de Buenos Aires entre julio de 2012 y octubre de 2017.
La búsqueda inicial en nuestra base de datos arrojó 180 historias clínicas. En 66 casos se confirmó el diagnóstico. Un 65% eran mujeres. La edad media fue 37 años. La prevalencia fue de 0,02%.
Las áreas más afectadas fueron las axilas, la vulva y las ingles. El tabaquismo y el sobrepeso u obesidad fueron las comorbilidades más frecuentes.
El sexo masculino y las localizaciones perianal y glútea, se asociaron a casos más graves.
El lapso al diagnóstico tuvo un intervalo muy amplio, desde un diagnóstico en la primera consulta, hasta una demora de 142 meses y 21 consultas previas.
Nuestros resultados se encuentran dentro de los valores de la literatura. Este es el primer trabajo de Argentina que describe la prevalencia, las comorbilidades y el error diagnóstico en la hidradenitis supurativa.
Hidradenitis suppurativa is a chronic recurrent systemic inflammatory disease that mainly involves large skin folds. It develops when pilosebaceous units become blocked, leading to the formation of painful nodules, abscesses, fistulas, and scarring. The impact of this disease on quality of life is great.
To describe the prevalence and clinical features of hidradenitis suppurativa in patients treated at Hospital Italiano de Buenos Aires and determine the frequency of comorbidities and time to diagnosis in this population.
Retrospective descriptive cross-sectional study. Information was extracted from the computerized clinical records of all patients with a diagnosis of hidradenitis suppurativa managed in Hospital Italiano de Buenos Aires between July 2012 and October 2017.
Our initial search of the records yielded 180 cases; the diagnosis was confirmed in 66 cases. Sixty-five percent of the patients were women, and the mean age was 37 years. The prevalence of this diagnosis was 0.02%.
The armpits, vulva, and groin were the locations most frequently affected. Smoking, overweight, and obesity were the most commonly recorded concomitant conditions.
Male sex and perianal and gluteal locations were associated with severity.
Time until diagnosis varied widely, ranging from diagnosis at the first visit in some cases to as long as 142 months and 21 visits.
Our findings are consistent with the literature on hidradenitis suppurativa. This is the first Argentinian study to describe the prevalence of this disease as well as the concomitant conditions found and the rate of diagnostic error.
S2k guideline for the treatment of hidradenitis suppurativa/acne inversa (ICD-10 code L73.2)
2024, Aktuelle Dermatologie
Passive smoking and hidradenitis suppurativa: a retrospective analysis
2023, Journal of the European Academy of Dermatology and Venereology
Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits
2022, Biomedicines

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Letter to the EditorA retrospective institutional study of the association of smoking with the severity of hidradenitis suppurativa

Highlights

Section snippets

Funding

Conflict of interest disclosure

Hidradenitis suppurativa (acne inversa) as a systemic disease

Clin. Dermatol.

What causes hidradenitis suppurativa?

Exp. Dermatol.

Hidradenitis suppurativa and associated factors: still unsolved problems

J. Am. Acad. Dermatol.

Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity

J. Am. Acad. Dermatol.

Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity

Br. J. Dermatol.

Letter to the Editor
A retrospective institutional study of the association of smoking with the severity of hidradenitis suppurativa