Reviews and feature articleIL-22–producing “T22” T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17–producing TH17 T cells
Section snippets
Study design
Peripheral blood and skin biopsies were collected from 12 patients with AD (age 23-48 years; median, 34 years) and 13 patients with psoriasis (age 28-60 years; median, 52 years) under a Rockefeller University institutional review board–approved protocol (Table I). Patients with moderate to severe psoriasis and >10% body surface area involvement, and patients with acute exacerbation of chronic AD (Scoring Atopic Dermatitis [SCORAD] between 21 and 72), were included in the study. A therapeutic
Results
Adult patients were studied with active lesions of chronic AD (n = 12) and psoriasis (n = 13) and clinical and demographic characteristics described in Table I.
Discussion
In this report, we explored the phenotype and cytokine production of different T-cell subsets in patients with chronic AD compared with psoriasis. Our findings expand current knowledge on the presence of TH17 T cells and shed new light on a unique subset of IL-22–producing T cells in blood (Fig 2) and skin (Figs 3 and 4) compartments of patients with chronic AD.
We found a significantly decreased frequency of CD4+ TH17 T cells in AD lesional skin compared with psoriasis, whereas comparable
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Supported by grant #5UL1RR024143-02 from the National Center for Research Resources, a component of the National Institutes of Health, and the National Institutes of Health Roadmap for Medical Research. K.E.N. is supported by the Clinical Scholars Program at the Rockefeller University, and L.C.Z. is supported by National Institutes of Health Medical Scientist Training Program (MSTP) grant GM07739.
Disclosure of potential conflict of interest: J. G. Krueger receives grant support from Centocor and Wyeth. The rest of the authors have declared that they have no conflict of interest.
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These authors contributed equally to this work.