Review
Interventional treatments for Hailey–Hailey disease

https://doi.org/10.1016/j.jaad.2016.08.039Get rights and content

Hailey–Hailey disease or familial benign chronic pemphigus is a rare blistering dermatosis that is characterized by recurrent erythematous plaques with a predilection for the skin folds. For extensive Hailey–Hailey disease that is recalcitrant to conventional therapy, laser ablation, photodynamic therapy, electron beam radiotherapy, botulinum toxin type A, dermabrasion, glycopyrrolate, and afamelanotide have been reported as useful treatments, but comparative trials are lacking. This review discusses the various treatment modalities for Hailey–Hailey disease and a summary of the evidence for the most recommended treatments.

Key words

botulinum toxin type A
familial benign chronic pemphigus
Hailey-Hailey disease
interventional treatments
laser ablation
recalcitrant Hailey-Hailey disease

Abbreviations used

ALA
aminolevulinic acid
BTX-A
botulinum toxin type A
CO2
carbon dioxide
HHD
Hailey–Hailey disease
MAL
methyl aminolevulinic acid
NA
not applicable
NR
not reported
PDT
photodynamic therapy
RF
radiofrequency

Cited by (0)

The first two authors contributed equally to this manuscript.

Funding sources: None.

Conflicts of interest: None declared.

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