ReviewCutaneous manifestations of IgG4-related disease (RD): A systematic review
Section snippets
Search strategy
A comprehensive systematic search of the literature was performed using the electronic database PubMed from January 1990 to August 2013 for all peer-reviewed publications pertaining to cutaneous manifestations of IgG4-RD. Search criteria were defined to include studies with specific key words in the title, abstract, or body. The search terms used were: “IgG4-related disease,” “IgG4-related sclerosing disease,” “hyper-IgG4 disease,” “IgG4-related systemic disease,” “retroperitoneal fibrosis,”
Results
The electronic search and bibliography screen with applied inclusion criteria retrieved 138 references. In all, 35 articles, consisting of case reports and case series, met inclusion criteria (Fig 1).10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43 Three articles including 16 cases were excluded given insufficient information to apply the diagnostic criteria. The remaining 32 articles comprising 58 cases were
Discussion
As IgG4-RD is a recently described multiorgan, systemic inflammatory disease, characteristic findings of cutaneous involvement in IgG4-RD have not to our knowledge been previously reported. This study reviewed 40 cases of cutaneous IgG4-RD. The primary finding was that the distribution of cutaneous IgG4-RD is significantly more likely to involve the head and neck than other areas of the body. Despite the frequency of the cutaneous presentation of papules, plaques, and nodules among cases, no
References (43)
- et al.
Cutaneous immunoglobulin G4-related systemic disease
Am J Med
(2011) - et al.
Clinicopathologic analysis of IgG4-related skin disease
Mod Pathol
(2013) - et al.
High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis–is this a cutaneous manifestation of IgG4-related disease?
Hum Pathol
(2009) - et al.
IgG4-related sclerosing disease clinically mimicking oral squamous cell carcinoma
Oral Surg Oral Med Oral Pathol Oral Radiol
(2013) - et al.
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease
Pathol Res Pract
(2012) Cutaneous inflammatory pseudotumor: a case report with immunohistochemical and ultrastructural studies
Pathology
(1993)- et al.
Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease
Mod Pathol
(2009) - et al.
IgG4-related disease
N Engl J Med
(2012) - et al.
High serum IgG4 concentrations in patients with sclerosing pancreatitis
N Engl J Med
(2001) - et al.
Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations
Arthritis Rheum
(2012)
Proposal for a new clinical entity, IgG4-positive multiorgan lymphoproliferative syndrome: analysis of 64 cases of IgG4-related disorders
Ann Rheum Dis
A novel clinical entity, IgG4-related disease (IgG4RD): general concepts and details
Mod Rheumatol
The clinical and pathological features of IgG(4)-related disease
Curr Rheumatol Rep
Comprehensive diagnostic criteria for IgG4 related disease (IgG4-RD), 2011
Mod Rheumatol
Cutoff values of serum IgG4 and histopathological IgG4 plasma cells for diagnosis of patients with IgG4-related disease
Int J Rheumatol
Isolated cutaneous manifestations of IgG4-related disease
J. Clin Pathology
IgG4-positive plasma cells in cutaneous Rosai-Dorfman disease: an additional immunohistochemical feature and possible relationship to IgG4-related sclerosing disease
J Cutan Pathol
Case report of anti-transcription intermediary factor-1-γ/α antibody-positive dermatomyositis associated with gastric cancer and immunoglobulin G4-positive pulmonary inflammatory pseudotumor
J Dermatol
IgG4-related skin disease successfully treated by thalidomide: a report of 2 cases with emphasis on pathological aspects
JAMA Dermatol
IgG4-related skin manifestations in patients with IgG4-related disease
Eur J Dermatol
IgG4-related neuropathy: a case report
JAMA Neurol
Cited by (36)
Imaging manifestations of IgG4-related disease
2023, Clinical RadiologyCutaneous IgG4-related disease associated with lymphocytic colitis
2023, JAAD Case ReportsAsymptomatic, reddish-brown papules and plaques in an elderly Japanese woman
2022, JAAD Case ReportsComprehensive analysis of protein-expression changes specific to immunoglobulin G4-related disease
2021, Clinica Chimica ActaCitation Excerpt :Diverse organs can be affected [3–6] and lymphocytic infiltration is pronounced; however, the fundamental tissue structures such as ducts are preserved, and during the early stage of disease, moderate amounts of corticosteroids can functionally restore affected organs. The clinical features of IgG4-related disease have been extensively investigated [7–9]; however, several ambiguities remain regarding the etiology and pathology of the disease. In IgG4-related disease, IgG4-positive plasma cells infiltrate IgG4-affected tissues [1,2] through an undetermined mechanism.
Immunoglobulin-G4–related skin disease
2021, Clinics in DermatologyCitation Excerpt :Clinically, cutaneous IgG4-RD presents as tumefactive lesions, swelling red-to-brown pruritic nodules, plaques, masses, or inflammatory pseudotumor lesions. The most common location is the face, particularly the cheek (Figure 1), peri-auricular region, mandibular area, neck, and less the arms and legs.28 Epidemiologically, skin involvement is similar to any other organ involvement, being more predominant in men.
Drs Charrow and Imadojemu contributed equally and are co-first authors.
Funding sources: None.
Disclosure: Dr Takeshita has a grant from Pfizer and received payment for CME work related to psoriasis. Dr Lipoff received a Pfizer Independent Grant for Learning and Change from the American Academy of Dermatology. Drs Charrow, Imadojemu, and Ogunleye have no conflicts of interest to declare.