Original articleCorrelation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement
Section snippets
Patients
We collected data from 855 patients given the diagnosis of HS between 2007 and 2014 in The Netherlands at the Department of Dermatology at the Erasmus University Medical Center, Rotterdam; the Deventer Hospital, Deventer; and the Department of Plastic Surgery at the Diaconessenhuis, Leiden. Data extraction took place partly from our HS database, also used by Schrader et al.5 For this type of retrospective analysis, no medical ethical committee approval is required under Dutch law.
Data collection
Patient
Results
A total of 620 women and 235 men, mean age 37.9 ± 12.8 years, were included (Table I). Body sites most frequently affected were the inguinal/genital (89.7%), axillary (64.3%), and gluteal (41.2%) areas. The (infra) mammary (20.7%), perianal (19.5%), and abdominal (16.7%) regions were least affected. Most patients were current smokers (70.5%) or ex-smokers (14.2%), who started smoking at a mean age of 16.1 ± 3.9 years.
Discussion
In this retrospective study of 855 patients, 66 (7.7%) reported early-onset HS. This is higher than previously reported (2%),7 indicating that early-onset HS is not so rare. Our results suggest that for HS, as with psoriasis and atopic dermatitis,9, 10 clinically different disease subsets can be distinguished based on age of onset.
In the early-onset group 56% reported a family history for HS, a higher proportion than the generally reported 35%.3, 11 This supports the findings of previous
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Funding sources: None.
Conflicts of interest: None declared.