Original articleEffect of tonsillectomy on psoriasis: A systematic review
Section snippets
Data search
We searched MEDLINE, CINAHL, Cochrane, EMBASE, Web of Science, and OVID databases for articles published from August 1, 1960, to September 12, 2013. For MEDLINE, the following Medical Subject Headings (MeSH) were combined using the AND command:
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Psoriasis [MeSH].
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Tonsillectomy [MeSH Major Topic] OR Tonsillitis [MeSH Major Topic].
We also combined the aforementioned terms in an identical manner to locate pertinent citations in the other electronic databases: EMBASE, CINAHL, OVID, Web of Science, and
Results
Based on the aforementioned inclusion and exclusion criteria, we identified 674 initial citations from the electronic search published over the past 53 years. After removal of duplicates, 249 citations were selected for additional assessment. Fig 1 is a flow diagram displaying the search process. Specifically, MEDLINE search yielded 57 unique citations, whereas the EMBASE and CINAHL searches resulted in 239 and 139 citations, respectively. The OVID search results generated 191 results. The
Discussion
This systematic review examines data from 545 patients from 8 countries in 20 studies. To our knowledge, this represents the most comprehensive systematic review on the effect of tonsillectomy on the clinical course of guttate and plaque psoriasis available to date.
The epidemiologic association between streptococcal infection and psoriasis has been noted for many decades, beginning in 1916 with the case report of Winfield42 on the emergence of psoriasis after acute tonsillitis. Since then,
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Cited by (48)
Intranasal streptococcal infection exacerbates psoriasis-like dermatitis via the induction of skin tissue-resident memory T cells
2023, Biochimica et Biophysica Acta - Molecular Basis of DiseaseTonsillectomy and the subsequent risk of psoriasis: A nationwide population-based cohort study
2021, Journal of the American Academy of DermatologyCitation Excerpt :A systematic review showed extended remission of psoriasis and an improvement in response after tonsillectomy.15 Another systematic review concluded that tonsillectomy may be an option for patients with recalcitrant psoriasis whose psoriasis is associated with a previous tonsillitis infection.16 However, because there is a risk of psoriasis relapse after tonsillectomy and of adverse effects of tonsillectomy, it is generally recommended that tonsillectomy be reserved for specific patients with recalcitrant psoriasis that is exacerbated after tonsillitis.16
Leptin in skin disease modulation
2021, Clinica Chimica ActaCitation Excerpt :The well-known EFs that are strongly linked to psoriasis include dietary habits along with obesity, microbiota, infections, alcohol intake, tobacco smoking, and psychological factors [45,46]. There are numerous studies concerning on the adipokine levels in a course of psoriasis, and these observations comprised not only leptin but also resistin, adiponectin, and others [47]. Higher levels of leptin in sera of psoriatic patients in comparison with the controls were observed [48,49].
Psoriasis
2021, The LancetCitation Excerpt :Whereas most children and young adults with guttate psoriasis have spontaneous resolution after several weeks or months, approximately 40% of cases progress to chronic plaque disease.19 The role of antibiotics in managing guttate psoriasis is unclear, but tonsillectomy has shown some benefit in recurrent cases associated with tonsillitis.17,20 The factors that dictate permanent resolution or persistence are unknown.
Psoriasis: pathological mechanisms, current pharmacological therapies, and emerging drug delivery systems
2020, Drug Discovery TodayCitation Excerpt :TNF-α, interferon γ (IFN-γ), IL-8, and VEGF are produced by mast cells, which leads to increased T cells and neutrophils at the site of inflammation. TNF-α activates the NF-κB signaling pathway, which mediates keratinocyte and lymphocyte cell survival, proliferation, and antiapoptotic effects [5,12,13]. Recent efforts to understand the molecular events in psoriasis lesions have led to the identification of new therapeutics, including PDE4 inhibitors (e.g., apremilast) and JAK inhibitors (e.g., tofacitinib).
Triggers for the onset and recurrence of psoriasis: a review and update
2024, Cell Communication and Signaling
Funding sources: None.
Disclosure: Dr Rachakonda has served as a subinvestigator for Amgen, Abbvie, and Lilly. Dr Armstrong serves as investigator and/or consultant to Abbvie, Amgen, Janssen, Lilly, Pfizer, Celgene, Novartis, UCB, Modernizing Medicine, and Merck. Dr Florek serves as a subinvestigator for Abbvie, Lilly, Janssen, Regeneron, and Novartis. Mr Dhillon has no conflicts of interest to declare.