Dermatologic surgeryThree-dimensional histology for dermatofibrosarcoma protuberans: Case series and surgical technique
Section snippets
Methods
The medical records of all patients with DFSP treated in our unit between April 2000 and May 2011 were reviewed. Diagnosis of DFSP was confirmed in all patients by biopsy. Patient demographics, along with clinical and surgical data, are summarized in Table I.
Results
During the last 2 decades, we have been treated 33 patients with DFSP using 3D histology surgery with paraffin sections. Four patients were excluded because of short follow-up (ie, <12 months). Of the 29 patients included in this study, 14 were female and 15 were male. Mean patient age was 40.7 years. As for tumor characteristic, 7 were located on the upper extremities, 15 on the trunk, 4 on the lower extremities, and 3 in the head and neck region (Table II). The mean average duration of tumor
Discussion
Traditionally, the mainstay of DFSP treatment has been surgical excision. However, because of the infiltrative growth that characterizes this kind of tumor, local recurrence after surgical excision tends to be high. In the past, for some authors wide local excision with negative margins was the optimal treatment. However, the optimal width of excision around the tumor has never been defined. and several series have been published with contradictory results.17, 18, 19 The classic recommendation
References (26)
- et al.
Mohs micrographic surgery for the treatment of dermatofibrosarcoma protuberans: results of a multiinstitutional series with an analysis of the extent of microscopic spread
J Am Acad Dermatol
(1997) - et al.
Dermatofibrosarcoma protuberans: wide local excision vs Mohs micrographic surgery
Cancer Treat Rev
(2008) Dermatofibrosarcoma protuberans resected by Mohs' surgery (chemosurgery): a 5-year prospective study
J Am Acad Dermatol
(1985)- et al.
Dermatofibrosarcoma protuberans
Cancer
(2004) - et al.
Dermatofibrosarcoma protuberans treated with Mohs micrographic surgery: cure rates and surgical margins
Dermatol Surg
(1996) - et al.
Mohs' micrographic surgery for dermatofibrosarcoma protuberans
Clin Exp Dermatol
(2010) - et al.
Current treatment options in dermatofibrosarcoma protuberans
J Cancer Res Clin Oncol
(2009) - et al.
Surgical treatment for dermatofibrosarcoma protuberans: the Dartmouth experience and literature review
Ann Plast Surg
(2008) - et al.
Mohs micrographic surgery and dermatofibrosarcoma protuberans: a multidisciplinary approach in 44 patients
Ann Plast Surg
(2008) - et al.
Dermatofibrosarcoma protuberans: a clinicopathologic analysis of patients treated and followed at a single institution
Cancer
(2000)
Transformed dermatofibrosarcoma protuberans: a clinicopathological study of eight cases
J Clin Pathol
Dermatofibrosarcoma protuberans: a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature
Cancer
Mohs micrographic surgery for dermatofibrosarcoma protuberans: University of Miami and NYU experience
Dermatol Surg
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Comparing Mohs micrographic surgery and wide local excision in the management of head and neck dermatofibrosarcoma protuberans: a scoping review
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Funding sources: None.
Conflicts of interest: None declared.