Original articleDeficiency of serum concentration of 25-hydroxyvitamin D in psoriatic patients: A case-control study
Section snippets
Patients and control subjects
This case-control study included 86 outpatients: 43 patients with psoriasis randomly selected from among patients of the psoriasis unit and 43 randomly selected age- and sex-matched control subjects (28 male and 15 female in each group) with nonphotosensitive dermatologic diseases other than psoriasis (mainly nevi, seborrheic keratosis, or verruca) from the Dermatology Department of San Cecilio University Hospital, Granada, Spain. Randomization was conducted using randomized number tables. All
Results
We studied 43 Caucasian patients (28 male and 15 female) with generalized psoriasis plaques. The mean time period with psoriasis was 19.91 years, the mean PASI value was 4.42, and the mean body surface area was 4.38. Of these 43 patients with psoriasis 14% had nail psoriatic arthritis and 7% had psoriatic arthritis. No gender differences were observed in any of the above parameters. A family history of psoriasis was reported by 46.8% of psoriatic patients versus 8.7% of the control subjects (P
Discussion
In this study, multivariate analysis showed that serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects after adjusting for confounding factors. The 25-OHD levels were negatively associated with CRP, a marker of inflammatory activation, and with BMI in multiple linear regression analysis. Psoriatic patients with BMI greater than or equal to 27 kg/m2 were found to have a greater risk of 25-OHD insufficiency, with high sensitivity and specificity. A strength
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Funding sources: None.
Conflicts of interest: None declared.