JAAD onlineDevelopment and validation of a vitiligo-specific quality-of-life instrument (VitiQoL)
Section snippets
Methods
Adult patients (n = 90) were recruited at two university dermatology clinics and from the general public. All protocols were approved and patient consent obtained in accordance with the institutional review board at both institutions.
Results
We recruited 90 patients (29 from New York, NY, and 61 from Chicago, IL) using advertisements, from a generated list of clinic patients who were given the diagnosis of vitiligo, and via direct recruitment in outpatient university-based dermatology clinic. At New York University, 7 participants were recruited through public advertisements while the rest were through outpatient clinics. At Northwestern University, the enterprise data warehouse search identified a total of 210 patients with
Discussion
This study represents the development and preliminary validation of a HRQL instrument specifically for patients with vitiligo. We ensured face and content validity by developing vitiligo-specific items from in-depth open-ended interviews with 16 patients, clinical input, and literature review. Exploratory factor analysis with oblique rotation revealed 3 factors: participation limitation, stigma, and behavior. We demonstrated reliability by high internal consistency. Concurrent validity was
Conclusion
As a significant step, a HRQL instrument (VitiQoL–an objective measure of disease status, burden of disease, and treatment outcome), specifically for patients with vitiligo, has been validated using vitiligo-specific items from in-depth open-ended patient interviews, clinical input, and literature review. There was strong correlation between self-reported severity and VitiQoL score (significant psychosocial impairment). Despite some limitations, a validated vitiligo-specific HRQL instrument is
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Supported by the Ambi Skin of Color Society Research Award.
The first two authors contributed equally to this article.
Conflicts of interest: None declared.