Original articlePrevalence of autosomal recessive congenital ichthyosis: A population-based study using the capture-recapture method in Spain
Section snippets
Methods
This was a prospective, population-based, cross-sectional study. The study protocol was approved by the Comité Etico de Investigación Clínica de Galicia (2010/445), and by the ASIC.
Lists of patients with ARCI were obtained from 3 sources: dermatology departments acting as reference centers, the reference center for genetic diagnosis of the disease, and the ASIC (including members of the association and other affected individuals of whom they were aware). All provided a list of patients with
Results
We identified 144 patients with ARCI. Of these, 21 were present in two sources, and 4 in 3. A table showing the overlap of the data sources is available from the corresponding author. Diagnoses are described in Table I. Age distribution of patients was compared with the age distribution of the Spanish population (Fig 1).
The capture-recapture method generates several models to fit the relationship between the different data sources. In our study, all models gave very similar estimates, which is
Discussion
Estimates of the prevalence of ARCI in the Spanish population ranged from 7.2 to 16.2 cases per million, depending on the age group. We also showed that individual data sources were incomplete, so the use of the capture-recapture technique was justified to improve the estimation.
Assumptions of the capture-recapture method are: (1) a closed population (not affected by migration), (2) correct identification of subjects and overlap between the different data sources, and (3) the probability of
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Funding sources: None.
Conflicts of interest: None declared.