ReviewIntralesional chemotherapy for nonmelanoma skin cancer: A practical review
Section snippets
Methods
A search of the MEDLINE database (1950-present) was conducted to identify original studies evaluating intralesional chemotherapy agents as the main therapy of nonmelanoma skin cancer (NMSC). The terms “squamous cell carcinoma,” “basal cell carcinoma,” “keratoacanthoma,” “fluorouracil,” “methotrexate,” “bleomycin,” and “interferon” were used in combination. Additional primary sources were identified in the reference lists of articles identified by the MEDLINE search. More than 2500 articles were
Results
Of the 56 articles included in our review, 51 of the sources were case reports, case series, or open-label studies. Four were prospective, dose-comparison studies and one was a randomized, placebo-controlled trial. Table I, Table II, Table III, Table IV organize these references and data according to the intralesional agent.
Discussion
Surgery remains the mainstay of treatment of invasive SCC and some BCC. For high-risk tumors, Mohs micrographic surgery is the standard of care, because of its consistently superior cure rates. In select circumstances, for example when excisional modalities have repeatedly failed or are not possible, the treatment of tumors with intralesional chemotherapy may be a reasonable option (Table VI). The lack of well-designed trials or guidelines for the use of intralesional chemotherapy leaves the
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