ReviewAntipruritic treatment with systemic μ-opioid receptor antagonists: A review
Section snippets
Methods
We conducted a literature research for reports on MORA in the treatment of chronic pruritus and itchy conditions. We searched different electronic databases (MEDLINE, Ovid, and DIMDI) using the free text key words “naltrexone,” “nalmefene,” “naloxone,” “opioid receptor antagonist,” “pharmacology,” “pruritus,” “itch,” and their combinations. Search was done without language restriction. Manufacturers of drugs and authors of articles were not contacted. In addition, we included information from
Results
Online search yielded a total of 318 reports from 1979 to 2009 containing the key words mentioned above. We included 58 clinical articles mainly reporting on chronic pruritus and some examples in acute pruritus. Case reports and studies on morphine-induced pruritus were excluded. The main topics addressed in these studies were the pharmacology of opioid receptor antagonists, their neuronal mechanism, and their clinical antipruritic potency.
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Conflicts of interest: None declared.