ReviewEfficacy and safety of treatments for childhood psoriasis: A systematic literature review
Section snippets
Methods
Three bibliographic databases were searched for articles published from January 1980 to September 2008: PubMed, EMBASE, and the Cochrane Controlled Clinical Trial Register. “Psoriasis,” “child,” and “treatment” were used as main key words, including all possible synonyms and antipsoriatic treatments (generic names and brand names). Languages were limited to English, German, and Dutch. Full details on the search strategy are available from the corresponding author on request. Because the
Results
In the results, all 116 full text articles are presented, as are the reasons for exclusion of 52 articles. The details on the 64 studies included are summarized in Table III.
Discussion
Literature concerning treatment efficacy and safety in childhood psoriasis is diverse. After thorough inspection of all literature, 64 studies could be included, describing 646 children in total. Of these 64 studies, only 6 were RCTs. Because of the paucity of RCTs, all LOEs were included in this study.
Most literature concerns induction of remission, rather than maintenance therapy. Although some studies describe treatment durations of up to almost 3.5 years,87 these are exceptional and
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Cited by (0)
Supported by University Medical Center St Radboud Foundation, which received funding from Wyeth Pharmaceuticals for the project. Wyeth Pharmaceuticals played no role in the design and execution of the study or in data collection, data management, data analysis, interpretation of the data, manuscript preparation, manuscript review, or manuscript approval.
Conflicts of interest: None declared.
Disclosure: Dr de Jager participated in trials funded by Schering Plough and Abbott. Dr de Jong served as consultant for Biogen, Serono, Wyeth, and Abbott. She also received research grants from Merck Serono and Wyeth. Dr van de Kerkhof served as consultant for Schering Plough, Cellgene, Centocor, Allmirall, UCB, Wyeth, Pfizer, Soffinova, Abbott, Actelion, Galderma, Novartis, Janssen Cilag, and Leo Pharma. He also received research grants from Centocor, Wyeth, Schering Plough, Merck Serono, Abbott, and Philips Lighting. Dr Seyger has served as a consultant for Wyeth and participated in trials funded by Schering Plough and Wyeth.