Case & reviewKikuchi's disease: Case report and systematic review of cutaneous and histopathologic presentations
Section snippets
Case report
A white woman, 24 years old, was evaluated for fevers and lymphadenopathy of 6 weeks' duration and 8 days of a pruritic, burning skin eruption on the cheeks, neck, trunk, and extremities. She reported headache, ear pain, tinnitus, sore throat, cough, loose stools, and vomiting. Her medical history included chronic back pain, tonsillectomy, adenoidectomy, repair of a nasal fracture, and nonsteroidal anti-inflammatory drug–induced ulcers and gastritis. Her medications included hydroxyzine,
Methods
A systematic search of the scientific literature from 1966 through January 2007 was conducted to identify all case reports and case series describing Kikuchi's disease. Cases were identified by searches of PubMed/MEDLINE with the MeSH term Histiocytic Necrotizing Lymphadenitis and the entry terms Kikuchi-Fujimoto Disease; Disease, Kikuchi-Fujimoto; Kikuchi Fujimoto Disease; Kikuchi's Disease; Disease, Kikuchi's; Kikuchis Disease; Kikuchi Disease; Disease, Kikuchi; Lymphadenitis, Histiocytic
Discussion
The classic findings of Kikuchi's disease are lymphadenopathy and fever.103, 104. The etiology is unknown. Infections have been implicated, including Epstein-Barr virus,61, 67, 83, 105 human herpesvirus,6, 23, 106 human herpesvirus 8,107 HIV,108 HTLV1,5 dengue virus,21 parvovirus B19,93Yersinia enterocolitica,109Bartonella,110Brucella,111 and Toxoplasma organisms.90 Kikuchi's disease affects all ethnic groups and is more common in women.74, 80 Most affected patients are younger than 40 years.112
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Funding sources: None.
Conflicts of interest: None declared.
Presented in poster format at the annual meeting of the American Academy of Dermatology, Washington, DC, February 2-6, 2007.