ReportNew prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas
Section snippets
Patients and samples
For examination we used formalin-fixed skin biopsy specimens from patients with LBCL-L and LFCL. An informed consent was obtained from each patient before biopsy. All biopsy specimens were taken for diagnostic reasons. For inclusion into our study the lymphoma had to be restricted to the skin at the time of diagnosis. This was confirmed by appropriate staging procedures. Patients with immunosuppression have been excluded from the study. We only included cases composed of diffuse arranged
Clinical parameters
In all, 35 patients with primary cutaneous LBCL were included into the study; 16 of them were male and 19 were female. The lymphomas were classified as LFCL in 14 cases and as LBCL-L in 21 cases.
The mean age was 64.6 years (SD 14.8, median 68 years, range 23-90 years) at the time of diagnosis and the mean follow-up was 60.2 months (median 59.5 months, range 4-156 months).
The distribution of the lesions included legs (14 cases with exclusive location on the leg: 6 right, 6 left, 2 bilateral),
Discussion
In this study we investigated clinical and immunophenotypic characteristics in a large number of PCDLBCLs including cases with LBCL-L and LFCL.
Both groups show significant differences in clinical presentation and prognosis. In LBCL-L the patients are usually older and present more often with multiple lesions. Pooling all lymphomas together we identified diagnosis, location on the leg, ulceration, and multiple lesions at presentation as significant prognostic factors. In our study all 5 patients
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