Letter
Keratoacanthomas associated with sorafenib therapy

https://doi.org/10.1016/j.jaad.2006.10.032Get rights and content

References (4)

  • ClinicalTrials.gov [database online]. Bethesda, MD: National Library of Medicine; 2006. Available at:...
  • D. Strumberg et al.

    Raf kinase inhibitors in oncology

    Onkologie

    (2005)
There are more references available in the full text version of this article.

Cited by (85)

  • Emergence of ocular toxicities associated with novel anticancer therapeutics: What the oncologist needs to know

    2022, Cancer Treatment Reviews
    Citation Excerpt :

    Sunitinib has been associated with retinal detachments (at least 24 cases) [54]. Sorafenib is associated with squamoproliferative lesions, such as keratoacanthomas, and squamous cell carcinoma affecting the eyelid [55], retinal detachments (at least 7 reported cases), and retinal tears (at least 2 reported cases) in case reports [54,56]. Management: Periorbital edema from imatinib is typically mild and can be managed conservatively.

  • Anticancer therapies associated with secondary cutaneous malignancies: A review of the literature

    2020, Journal of the American Academy of Dermatology
    Citation Excerpt :

    This dose-dependent BRAF inhibitor–induced cutaneous toxicity substantiates the rates of SCM across the classes of drugs sharing this mechanism.13 Since 2006, when Lacouture et al35 reported the first cases of MKI-induced SCM, multiple publications have described a wide spectrum of squamoproliferative lesions,36-39 including follicular infundibular ectasia, inflamed actinic keratoses, KAs, and invasive cSCC.36 An association between MKIs and secondary BCCs has also been suggested, but no adequate mechanisms have been determined.

  • Targeted therapy in melanoma

    2013, Clinics in Dermatology
    Citation Excerpt :

    It has been reported to have the microscopic appearance of a lobular, neutrophilic panniculitis. A variety of other side effects, such as xerosis, keratosis pilaris (Figure 5), pruritus, paronychia, alopecia mimicking androgenic alopecia, and a change in hair texture to a “strawlike,” dry, and fine consistency83-87 have been reported. Localized or diffuse hyper- or hypopigmentation have also frequently been reported.89

View all citing articles on Scopus
View full text