Case ReportAcrokeratosis paraneoplastica (Bazex's syndrome): Association with liposarcoma
Section snippets
Case report
A 71-year-old man, in good general health, was referred to our department with a diagnosis of suggested psoriasis vulgaris. He underwent extirpation of a liposarcoma in the right retroperitoneum 4 months before admission. Six weeks after operation, the patient developed a psoriasiform and moderately itching dermatitis.
He showed, typically for acrokeratosis paraneoplastica, erythematosquamous papules and plaques distributed symmetrically in the region of the knuckles, fingernails, fingertips,
Discussion
Bazex et al1, 6 described acrokeratosis paraneoplastica as evolving in 3 stages. Stage I is marked by symmetrically squamous, psoriasiform erythema of the tips of fingers and toes (nail changes frequently occurring), followed by scaling of the back of the nose and the helical region. Symptoms of the malignant disease are absent here. Stage II consists of skin lesions spread in a centripetal pattern. At this time, early general tumor-related symptoms are observed. Stage III is marked by the
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Cited by (15)
Annular and acral/facial dyskeratotic paraneoplastic disorders
2023, Clinics in DermatologyCutaneous alerts in systemic malignancy: Part 1
2013, Actas Dermo-SifiliograficasCitation Excerpt :Palmoplantar hyperkeratosis is more common at the pressure points of the palm and does not affect the central area. The lesions can precede the detection of the underlying malignancy by a year; commonly associated malignancies are squamous cell carcinomas of the larynx, esophagus, and lung,48,49 but some cases have been reported in other malignancies, including ductal breast adenocarcinoma, cholangiocarcinoma, adenocarcinoma of the colon and prostate,50 lymph node metastasis in the neck, and liposarcoma.51 Several factors have been implicated in the pathogenesis of acrokeratosis paraneoplastica of Bazex, including antigen cross-reactivity between the tumor and the skin, production of a keratinocyte growth factor, vitamin A deficiency, and genetic susceptibility.
Miscellaneous conditions
2009, Weedon's Skin Pathology: Third EditionBazex syndrome or dermatomyositis?
2007, Journal of the American Academy of DermatologyA Review of Nail Changes in Acrokeratosis Paraneoplastica (Bazex Syndrome)
2021, Skin Appendage DisordersCutaneous paraneoplastic manifestations in gynecologic oncology
2021, Gynakologe
Funding sources: None.
Conflicts of interest: None identified.