Case ReportThree cases of lymphomatoid papulosis with a CD56+ immunophenotype
Section snippets
Case 1
A 29-year-old Caucasian man presented in 2002 with a 4-year history of recurring erythematous, crusted papules and nodules occurring on his arms and legs. The lesions lasted 2 to 3 months and healed with postinflammatory hyperpigmentation. He had no hepatosplenomegaly or lymphadenopathy. The disease pursued an indolent course with no treatment and the patient was subsequently lost to follow-up.
A skin biopsy specimen of a papule showed an epidermotropic infiltrate of medium atypical lymphocytes
Discussion
Only two cases of LyP with a CD56+ immunophenotype have been reported in the literature.3, 4 The initial case, reported by Bekkenk et al,3 described a patient with a 20-year history of recurrent self-healing skin lesions together with a CD30+ lymphoproliferative disease histologically, consistent with a diagnosis of LyP. The immunohistochemical findings were CD30+ and CD56+, but CD2−, CD3−, CD4−, CD8−, and TIA-1−. The disease had already pursued an indolent course for 20 years and was
References (9)
- et al.
Spectrum of primary cutaneous CD30 (Ki-1)-positive lymphoproliferative disorders: a proposal for classification and guidelines for management and treatment
J Am Acad Dermatol
(1993) - et al.
Mycosis fungoides with a CD56 positive immunophenotype: a report of three cases
J Am Acad Dermatol
(2005) - et al.
Lymphomatoid papulosis with a natural killer-cell phenotype
Br J Dermatol
(2001)
Cited by (27)
Cutaneous nonmycotic T- and natural killer/T-cell lymphomas: Diagnostic challenges and dilemmas
2014, Journal of the American Academy of DermatologyCitation Excerpt :Type-C (anaplastic large-cell lymphoma [ALCL]-like) lesions comprise monotonous or large sheets of CD30+ large cells with relatively few inflammatory cells. Very rare cases of LyP may express CD56, although the clinical course is indolent.29,30 Recently 2 morphologic variants have been proposed, namely epidermotropic cytotoxic (type D) and angioinvasive (type E).31-33
Lymphomatoid papulosis: Clinical and pathological findings in 18 patients
2012, Actas Dermo-SifiliograficasA case of indolent CD56-positive lymphomatoid papulosis
2010, Journal of the American Academy of DermatologyCutaneous infiltrates - lymphomatous and leukemic
2009, Weedon's Skin Pathology: Third EditionCutaneous CD30 lymphoproliferative disorders and similar conditions: a clinical and pathologic prospective on a complex issue
2009, Seminars in Diagnostic PathologyCitation Excerpt :However, recent study showed CD15 expression in 18% of LyP cases compared with 43% of CALCL.14 The anaplastic lymphoma kinase protein (ALK-1) is usually negative and coexpression of CD56 is observed in rare cases, but does not appear to be associated with an unfavorable prognosis.15 Pseudocarcinomatous epidermal hyperplasia was found in cases of LyP and CD30+ CALCL possibly associated with epidermal growth factor dysregulation.38
Mucosal involvement in lymphomatoid papulosis: Four cases
2008, Annales de Dermatologie et de Venereologie
Funding sources: None.
Conflicts of interest: None identified.
Reprint requests: Robin Russell-Jones, MA, FRCP, FRCPath, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Rd, London SE1 7EH, United Kingdom.