DermatopathologyIn vivo confocal scanning laser microscopy of benign lentigines: Comparison to conventional histology and in vivo characteristics of lentigo maligna
Section snippets
Patients
Patients were recruited prospectively during the period February 2002 through July 2005 for an ongoing Institutional Ethics Committee–approved study of CSLM at our pigmented lesion clinic at the Queen Elizabeth II Health Sciences Centre, Dalhousie University. Patients gave oral and written consent for the study. All patients were scheduled for biopsy of their lesion due to clinical suspicion of malignancy because of clinical appearance or change in the lesion.
Results
Ten patients were enrolled in this study, with lesions including 1 lentigo simplex, 1 lentigo simplex/evolving junctional nevus (“jentigo”), 4 solar lentigines, and 4 LMs. Demographic information, lesion characteristics, and pathologic diagnosis are listed in Table I. Patients' ages ranged from 39 to 70 years (mean, 53 years) and included 6 men and 4 women.
Discussion
Reflectance in vivo confocal microscopy has been recently investigated in dermatology as a tool with the potential to aid in clinical diagnosis of benign and malignant skin lesions. The nondestructive nature of optical “sectioning” avoids artifacts due to tissue processing and provides a high-resolution, instantaneous examination of the skin in its natural state, so dynamic processes and architectural and cellular features of the skin can be visualized.10, 17 Lentigines are particularly suited
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Supported by grants from Canadian Institute for Health Research/Faculty of Medicine, Dalhousie University Summer Studentship; Nova Scotia Health Research Foundation, and the Canadian Dermatology Foundation.
Conflicts of interest: None identified.
Study presented at the 14th Congress of the European Academy of Dermatology and Venereology, London, United Kingdom, Oct 12-16, 2005.