ReportEvaluating psoriasis with Psoriasis Area and Severity Index, Psoriasis Global Assessment, and Lattice System Physician's Global Assessment
Section snippets
Methods
Thirty-five patients with psoriasis were recruited for the study from the outpatient department, phototherapy unit, and the Day Treatment Center of the University of Michigan Department of Dermatology. Dermatology nurses asked patients to participate with a goal to recruit a range of severity of psoriasis; patients gave consent and were compensated for their time. No medications were used during the study; the patients were not participating in other research studies nor were they invited to do
Relationships of the rating systems to each other
The Spearman correlation coefficients for all physicians between PASI and PGA (0.87), PASI and LS-PGA (0.86), and PGA and LS-PGA (0.83) indicate that the measures were highly correlated. (A coefficient of 1 would indicate complete agreement of the scores whereas 0 would indicate absolutely no relationship among the scores.) These relationships were similar for both experienced and inexperienced raters for PASI and PGA (0.88 vs 0.86 respectively), PASI and LS-PGA (0.87 vs 0.86), and PGA and
Discussion
In this interrater and intrarater variability study, the psoriasis assessments, PASI, PGA, and LS-PGA, were assessed twice in 35 subjects by 17 raters yielding over 3300 completed observations. The PASI, PGA, and LS-PGA were highly correlated with each other (r > 0.8 for all comparisons). We did not expect a perfect correlation, which would have indicated that the rating systems were exactly the same; yet we expected the high correlations we found because all 3 systems attempt to measure the same
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Supported by Biogen, Inc., Cambridge, Mass.
Disclosure: A patent on the Lattice System Physician's Global Assessment has been filed by Dr Ellis.
Presented in part at the International Investigative Dermatology 2003 meeting, South Miami Beach, Florida, April 30-May 4, 2003.