Elsevier

Clinics in Dermatology

Volume 26, Issue 2, March–April 2008, Pages 177-181
Clinics in Dermatology

Biorejuvenation: theory and practice

https://doi.org/10.1016/j.clindermatol.2007.09.011Get rights and content

Abstract

The aim of mesotherapy for skin rejuvenation is to increase the biosynthetic capacity of fibroblasts, inducing the reconstruction of an optimal physiologic environment, the enhancement of cell activity, and the synthesis of collagen, elastin, and hyaluronic acid.

The desired final effect is a firm, bright, and moisturized skin, and the injection in the superficial dermis of suitable products—perfectly biocompatible and totally absorbable—can achieve these results.

In addition to a daily sunscreen application and nonsmoking, mesotherapy is another antiaging strategy helping to maintain a globally firm and bright skin, protecting it from the environmental contributors to aging.

Section snippets

Theory

Biorejuvenation is a common term to indicate mesotherapy for skin rejuvenation (also called biorevitalization or mesolift).

The goal of this technique is to increase the biosynthetic capacity of fibroblasts, inducing the reconstruction of an optimal physiologic environment, the enhancement of cell activity, and the synthesis of collagen, elastin, and hyaluronic acid (HA). The desired final effect is a firm, bright, and moisturized skin, and the injection in the superficial dermis of suitable

Practice10

After the obtainment of a signed informed consent, the physician will clean the skin of the patient using an antiseptic solution (alcohol free) and will perform microinjections with a 5-mL Luer-Lock syringe equipped with a 30 1/2- or 32-G, 4-mm needle or with a syringe with a skin injection therapy 2.5-mm needle or with a Meso-gun.

The injection techniques that can be performed are the following (always keeping the needle with an inclination of 45°):

  • Picotage (Fig. 1, Fig. 2). Performing of

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