Brief report
Bull's-eye maculopathy associated with quinacrine therapy for malaria

https://doi.org/10.1016/j.ajo.2003.08.047Get rights and content

Abstract

Purpose

To report a side effect of quinacrine therapy for malaria.

Design

Case report.

Methods

Review of clinical chart and photographs.

Setting

Private retina practice.

Results

A patient developed a bilaterally symmetric bull's-eye maculopathy 45 years after taking quinacrine for 18 months as prophylaxis against malaria. Progression of the clinical picture was documented over 15 years of follow-up. The clinical picture was identical to that of chloroquine and hydroxychloroquine maculopathy.

Conclusions

Low dosages of quinacrine used for malaria prophylaxis can be associated with a delayed, severe maculopathy indistinguishable from chloroquine maculopathy in certain patients.

References (5)

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