Data for this review were identified by searches of papers published in English on Medline, spanning the years 1975 through February 1, 2005 with the key words: “cellulitis”, “skin”, “soft tissue infection”, “rapidly progressive”, “rapidly spreading”, “rapid”, “necrotizing”, “fasciitis”, “myonecrosis”, “management”, and “treatment” in association with “group A streptococcus”, “Streptococcus pyogenes”, “Pasteurella”, “Clostridium”, “Aeromonas”, and “Vibrio”. Relevant references were also
ReviewRapidly progressive soft tissue infections
Introduction
Skin and soft tissue infections (SSTIs) account for approximately 7–10% of hospitalisations in North America.1, 2 There have been several excellent reviews of skin and soft tissue infections and their management. However, these reviews focus primarily upon classification systems, as well as diagnostic and therapeutic interventions for all the SSTIs, including the diabetic foot,2, 3, 4, 5, 6 but not specifically addressing those that are rapidly progressive. Thus, this overview will focus specifically upon rapidly progressive SSTIs. Infections caused by Staphylococcus aureus, particularly meticillin-resistant S aureus (MRSA), will be briefly addressed, as they have been reviewed elsewhere.2, 3, 7
Section snippets
Classification
The classification of SSTIs is complex. Some classification schemes have divided SSTIs into academic categories that may not be directly applicable at the bedside. However, a practical approach based on history and physical examination should be directed towards answering the following questions: “which organisms are likely to be involved?”, “what is the depth of the infection?”, and “is the infection life or limb threatening?”. The first question will guide empirical antimicrobial therapy. The
Pathophysiology
The skin and surrounding soft tissue is divided, from the most superficial to deeper structures, into the epidermis and dermis, the subcutaneous tissue (which contains vascular structures and nerves), and the fascia and muscle. Although any of these layers may be involved in the spectrum of SSTIs, the more severe infections tend to be associated with deeper tissue invasion. The portal of entry for microorganisms to gain access to the skin and soft tissue is most commonly trauma to the external
Community-acquired MRSA
S aureus is one of the most common causes of cellulitis. Cellulitis caused by S aureus can be difficult, if not impossible, to distinguish clinically from that caused by group A streptococcus, but it is usually associated with skin trauma, and is more likely to be bullous.2 If inadequately treated, local abscesses, necrotising fasciitis, or septicaemia may occur. As less than 5% of clinical isolates of S aureus are currently susceptible to penicillin because of the production of a
Conclusions
When a patient presents with a rapidly progressive SSTI, the potential consequences of the disease can be frightening. Clinicians must remember that only a limited number of common organisms can produce this entity. Clinically, it may be impossible to differentiate the aetiological agents responsible for the episode of rapidly progressive SSTI. Clues from the history, combined with characteristic clinical findings—eg, lesions with distinct raised borders or rapidly spreading crepitant
Search strategy and selection criteria
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2017, Medicine (United Kingdom)Tetanus after envenomations caused by freshwater stingrays
2015, ToxiconCitation Excerpt :We also reported an injury by Potamotrygon motoro that occurred in a biologist who was in an aquarium and evolved with necrosis and a serious local infection caused by Aeromonas caviae and requiring a skin graft (Minnaganti et al., 2000; Torrez et al., 2012). A substantial proportion of community-acquired, rapidly progressive soft tissue infections are monomicrobial and the most common causes are: group A. streptococcus, Clostridium perfringens, Pasteurella ssp, Aeromonas hydrophila and Vibrio spp. (Vinh and Embil, 2005; Finkelstein and Oren, 2011). But the bacteria most often associated with secondary infection after traumatic injury in skin in the freshwater exposure is Aeromonas.
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2015, BiochimieCitation Excerpt :Because of this multifunctional properties exhibited by γ-PLIs, we assumed that PIP protein and peptides could possibly display antibacterial activity like that exhibited by Habu snake PLIs [60]. Our BLASTP and Clustal Omega multiple sequence alignment results showed that PIP [26,29,34,56–69] segment had a 41% sequence identity with T. flavoviridis PLI [72–88] sequence segment, and the stretch of short amino acid sequences on both PIP and T. flavoviridis PLIs show 40% sequencey identity with the ADP-based amphibian (Australian frog) skin antimicrobial peptides. As shown in Table 4, these two peptide families from the two contrasting animal species, namely, snake blood PLI and amphibian skin antimicrobial peptides, do share the structural motifs that could possibly be explained by their common putative antimicrobial properties.
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