Clinical PictureDigital gangrene and Raynaud's phenomenon as complications of lung adenocarcinoma
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Vascular disease prevention: Before cancer therapy
2022, Cardio-Oncology Practice Manual: A Companion to Braunwald's Heart DiseaseCauses and outcomes of finger ischemia in hospitalized patients in the intensive care unit
2018, Journal of Vascular SurgeryAutoimmune paraneoplastic syndromes associated to lung cancer: A systematic review of the literature: Part 2: Hematologic, cutaneous and vascular syndromes
2017, Lung CancerCitation Excerpt :The frequent association with AC could be related to the mucus producing and its capacity to induce aPL [73]. Twelve single case reports were dedicated to this category [6,28,74–83]. Clinical features were classical Raynaud phenomenon described as classical discolored finger (initially white or blue then red) with discomfort, worsened in nine of the cases by reaching painful digital necrosis and not triggered by cold exposure.
Paraneoplastic Acral Vascular Syndrome
2015, Actas Dermo-SifiliograficasRheumatic Manifestations of Cancer
2011, Rheumatic Disease Clinics of North AmericaCitation Excerpt :This finding has recently been corroborated in a European population.62 The Raynaud phenomenon, a common manifestation of scleroderma, can also be an isolated manifestation of occult malignancy and, in some cases, the presenting manifestation.63–65 The Raynaud phenomenon together with panniculitis has also been described as a cutaneous manifestation of myeloma.66
Neoplastic and paraneoplastic vasculitis, vasculopathy, and hypercoagulability
2011, Rheumatic Disease Clinics of North AmericaCitation Excerpt :The episodic ischemia is characterized by a three-phasic color change of digital tips (pallor, cyanosis, and hyperemia). Unlike CLV, paraneoplastic Raynaud's is not associated with lymphoproliferative disorders but seems to be associated with metastatic solid tumors such as breast,71 ovarian,72 lung,73 head and neck,74 hepatocellular,75 and colorectal76 carcinomas. Raynaud's as a neoplastic phenomenon was first reported in 1884 in a middle-aged female with breast cancer metastatic to her cervical sympathetic trunk,77 leading to overstimulation of the sympathetic trunk, much like what is seen with connective tissues diseases.