Información del artículo
Abstract
This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms behind psoriasis is described. The roles of different components of the adaptive and innate immune systems involved in driving the inflammatory response are explained. Discovery of new immune pathways i.e. the IL23/Th17 axis and its subsequent impact on the development of novel biological therapies is highlighted. Identification of potential targets warranting further research for future therapeutic development are also discussed.
Key words:
psoriasis
immunopathogenesis
T cells
adaptive/innate immune response
Resumen
Esta revisión se centra en el notable progreso que ha generado la aplicación de la investigación básica al conocimiento clínico, y viceversa, en la comprensión de la inmunopatogenia de la psoriasis. Se describe la trayectoria en el conocimiento de los mecanismos patogénicos de la psoriasis; se explican los roles de los diferentes componentes de los sistemas inmunológicos, adaptativo e innato, implicados en la respuesta inflamatoria; se destaca el descubrimiento de nuevas vías inmunológicas, como por ejemplo el eje Il23/Th17 y su posterior impacto en el desarrollo de terapias biológicas novedosas y también se discute la identificación de potenciales dianas que justifican una investigación adicional para el desarrollo terapéutico futuro.
Palabras clave:
psoriasis
inmunopatogenia
células T
respuesta inmunológica adaptativa/innata
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