TY - JOUR T1 - Switching From Conventional Photodynamic Therapy to Daylight Photodynamic Therapy For Actinic Keratoses: Systematic Review and Meta-analysis JO - Actas Dermo-Sifiliográficas T2 - AU - Tomás-Velázquez,A. AU - Redondo,P. SN - 15782190 M3 - 10.1016/j.adengl.2017.03.007 DO - 10.1016/j.adengl.2017.03.007 UR - https://www.actasdermo.org/es-switching-from-conventional-photodynamic-therapy-articulo-S1578219017300574 AB - Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization. The conclusion is that the difference in efficacy is clinically negligible (global estimate of the mean response rate difference,–3.69%; 95% CI,–6.54% to–0.84%). The adverse effects of daylight PDT are mild and localized (79% of patients report no discomfort), and patients report less pain (P<.001). Daylight PDT gives good to excellent cosmetic results in more than 90% of patients, and patient satisfaction is greater (P<.001). ER -