Extracorporeal Photopheresis in Dermatology | Actas Dermo-Sifiliográficas

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"apellidos" => "Pérez-Carmona" "email" => array:1 [ 0 => "lpcarmona@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "¿" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "Harto-Castaño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Díez-Recio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario de Guadalajara, Universidad de Alcalá, Guadalajara, Spain" "etiqueta" => "b" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Carretera de Colmenar Viejo, km 9,100, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fotoféresis Extracorpórea en Dermatología" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2009-02-11" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84509" "palabras" => array:4 [ 0 => "photopheresis" 1 => "photochemotherapy" 2 => "extracorporeal" 3 => "treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84510" "palabras" => array:4 [ 0 => "fotoféresis" 1 => "fotoquimioterapia" 2 => "extracorpórea" 3 => "tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy. Blood from the patient is processed to give a leukocyte-rich plasma, which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient. The exact mechanism of action of photopheresis has not been fully elucidated although it is thought that induction of leukocyte apoptosis and formation of dendritic cells is essential for the development of an immune response to pathogenic cells. Extracorporeal photopheresis was initially used for treating cutaneous T-cell lymphoma. Since then, in view of its efficacy and safety, it has been used in a number of cutaneous and non cutaneous diseases with uneven results, which can in part be explained by the different patient selection criteria, therapy regimens, and follow-up protocols used in different hospitals." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "La fotoquimioterapia extracorpórea o fotoféresis es una terapia inmunomoduladora que combina la leucoféresis con la fototerapia. Después de la separación de un plasma rico en leucocitos, se administra ex vivo un fotosensibilizante junto con radiación ultravioleta A y posteriormente se reinfunde en el paciente. El mecanismo de acción exacto de la fotoféresis no se conoce completamente, aunque se piensa que la inducción de apoptosis de linfocitos y la formación de células dendríticas desempeña un papel fundamental en el desarrollo de una respuesta inmunológica contra las células patógenas. Esta terapia se utilizó inicialmente para el tratamiento del linfoma cutáneo de células T. Desde entonces, basándose en su eficacia y seguridad, se ha empleado en múltiples patologías tanto cutáneas como no cutáneas, con resultados variables. 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Estadísticas

Controversies in dermatology

Extracorporeal Photopheresis in Dermatology

Fotoféresis Extracorpórea en Dermatología

L. Pérez-Carmonaa,

Autor para correspondencia

lpcarmona@hotmail.com

Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal, Carretera de Colmenar Viejo, km 9,100, 28034 Madrid, Spain.

, A. Harto-Castañoa, E. Díez-Reciob, P. Jaén-Olasoloa

a Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, Spain

b Servicio de Dermatología, Hospital Universitario de Guadalajara, Universidad de Alcalá, Guadalajara, Spain

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        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Extracorporeal photochemotherapy or photopheresis is an immunomodulatory therapy that combines leukapheresis with phototherapy&#46; Blood from the patient is processed to give a leukocyte-rich plasma&#44; which is then treated ex vivo with a photosensitizer and ultraviolet A radiation before reinfusion back into the patient&#46; The exact mechanism of action of photopheresis has not been fully elucidated although it is thought that induction of leukocyte apoptosis and formation of dendritic cells is essential for the development of an immune response to pathogenic cells&#46; Extracorporeal photopheresis was initially used for treating cutaneous T-cell lymphoma&#46; Since then&#44; in view of its efficacy and safety&#44; it has been used in a number of cutaneous and non cutaneous diseases with uneven results&#44; which can in part be explained by the different patient selection criteria&#44; therapy regimens&#44; and follow-up protocols used in different hospitals&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La fotoquimioterapia extracorp&#243;rea o fotof&#233;resis es una terapia inmunomoduladora que combina la leucof&#233;resis con la fototerapia&#46; Despu&#233;s de la separaci&#243;n de un plasma rico en leucocitos&#44; se administra ex vivo un fotosensibilizante junto con radiaci&#243;n ultravioleta A y posteriormente se reinfunde en el paciente&#46; El mecanismo de acci&#243;n exacto de la fotof&#233;resis no se conoce completamente&#44; aunque se piensa que la inducci&#243;n de apoptosis de linfocitos y la formaci&#243;n de c&#233;lulas dendr&#237;ticas desempe&#241;a un papel fundamental en el desarrollo de una respuesta inmunol&#243;gica contra las c&#233;lulas pat&#243;genas&#46; Esta terapia se utiliz&#243; inicialmente para el tratamiento del linfoma cut&#225;neo de c&#233;lulas T&#46; Desde entonces&#44; bas&#225;ndose en su eficacia y seguridad&#44; se ha empleado en m&#250;ltiples patolog&#237;as tanto cut&#225;neas como no cut&#225;neas&#44; con resultados variables&#46; Los distintos centros han utilizado diferentes criterios de selecci&#243;n de pacientes&#44; pautas de tratamiento y protocolos de monitorizaci&#243;n&#44; lo que podr&#237;a contribuir a la diferencia de resultados&#46;</p>"
      ]
    ]
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Información del artículo

ISSN: 15782190
Idioma original: Inglés

DOI:10.1016/S1578-2190(09)70102-7

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