array:24 [
  "pii" => "S0001731023008670"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2023.10.033"
  "estado" => "S300"
  "fechaPublicacion" => "2024-01-01"
  "aid" => "3726"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2023"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2024;115:T28-T35"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731023006890"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2023.08.006"
    "estado" => "S300"
    "fechaPublicacion" => "2024-01-01"
    "aid" => "3634"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2024;115:36-47"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Caracter&#237;sticas cl&#237;nicas y epidemiol&#243;gicas de pacientes diagnosticados de escabiosis en Espa&#241;a&#58; oportunidades de mejora&#46; Estudio transversal multic&#233;ntrico CLINI-AEDV"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:3 [
        0 => "es"
        1 => "es"
        2 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "36"
          "paginaFinal" => "47"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Clinical and Epidemiological Characteristics of Patients Being Treated for Scabies in Spain&#58; Opportunities for Improvement &#8212; A Multicenter Cross-Sectional CLINI-AEDV Study"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0005"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 888
              "Ancho" => 1333
              "Tamanyo" => 185297
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C&#46; Galv&#225;n Casas, R&#46; Ruiz-Villaverde, &#193;&#46; Prados-Carmona, &#193;&#46; Fern&#225;ndez Camporro, A&#46;G&#46; Angulo Men&#233;ndez, M&#46;C&#46; &#193;lvarez-Buylla Puente, P&#46; Pasquali, &#193;&#46; Aguado V&#225;zquez, E&#46; Masferrer, L&#46; Rodr&#237;guez Gonz&#225;lez, D&#46; Ruiz-S&#225;nchez, C&#46;F&#46; Caballero-Linares, A&#46; Tejera-Vaquerizo, N&#46; Iglesias-Pena, S&#46; Fern&#225;ndez de Pi&#233;rola, C&#46; Maldonado-Seral, M&#46; Armengot-Carb&#243;, L&#46; Alonso-Naranjo, R&#46; Barros Tornay, T&#46; Solano Novo, V&#46; Fern&#225;ndez Tapia, A&#46; Mart&#237;n-Gorgojo, J&#46; Adsuar Mas, M&#46;E&#46; Parera Amer, P&#46; P&#233;rez Feal, R&#46; Taberner, M&#46; Utrera-Busquets, I&#46; Vicente S&#225;nchez, L&#46; Palacio Aller, I&#46; S&#225;nchez-Guti&#233;rrez, T&#46; Usero-B&#225;rcena, B&#46; Aldea Manrique, A&#46; S&#225;nchez Vel&#225;zquez, E&#46; Mart&#237;nez Garc&#237;a, M&#46; Grau-P&#233;rez, I&#46; Garc&#237;a-Doval"
          "autores" => array:37 [
            0 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Galv&#225;n Casas"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Ruiz-Villaverde"
            ]
            2 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Prados-Carmona"
            ]
            3 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Fern&#225;ndez Camporro"
            ]
            4 => array:2 [
              "nombre" => "A&#46;G&#46;"
              "apellidos" => "Angulo Men&#233;ndez"
            ]
            5 => array:2 [
              "nombre" => "M&#46;C&#46;"
              "apellidos" => "&#193;lvarez-Buylla Puente"
            ]
            6 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Pasquali"
            ]
            7 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Aguado V&#225;zquez"
            ]
            8 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Masferrer"
            ]
            9 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Rodr&#237;guez Gonz&#225;lez"
            ]
            10 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ruiz-S&#225;nchez"
            ]
            11 => array:2 [
              "nombre" => "C&#46;F&#46;"
              "apellidos" => "Caballero-Linares"
            ]
            12 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Tejera-Vaquerizo"
            ]
            13 => array:2 [
              "nombre" => "N&#46;"
              "apellidos" => "Iglesias-Pena"
            ]
            14 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Fern&#225;ndez de Pi&#233;rola"
            ]
            15 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Maldonado-Seral"
            ]
            16 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Armengot-Carb&#243;"
            ]
            17 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Alonso-Naranjo"
            ]
            18 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Barros Tornay"
            ]
            19 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Solano Novo"
            ]
            20 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Fern&#225;ndez Tapia"
            ]
            21 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Gorgojo"
            ]
            22 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Adsuar Mas"
            ]
            23 => array:2 [
              "nombre" => "M&#46;E&#46;"
              "apellidos" => "Parera Amer"
            ]
            24 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "P&#233;rez Feal"
            ]
            25 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Taberner"
            ]
            26 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Utrera-Busquets"
            ]
            27 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Vicente S&#225;nchez"
            ]
            28 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Palacio Aller"
            ]
            29 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "S&#225;nchez-Guti&#233;rrez"
            ]
            30 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Usero-B&#225;rcena"
            ]
            31 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Aldea Manrique"
            ]
            32 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "S&#225;nchez Vel&#225;zquez"
            ]
            33 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Mart&#237;nez Garc&#237;a"
            ]
            34 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Grau-P&#233;rez"
            ]
            35 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Garc&#237;a-Doval"
            ]
            36 => array:1 [
              "colaborador" => "CLINI-AEDV"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0005"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023006890?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023006890/v1_202401030514/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0001731023006798"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2023.07.019"
    "estado" => "S300"
    "fechaPublicacion" => "2024-01-01"
    "aid" => "3624"
    "copyright" => "AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2024;115:28-35"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
      "titulo" => "Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia&#58; A Multicenter Study of 264 Patients"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:3 [
        0 => "en"
        1 => "en"
        2 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "28"
          "paginaFinal" => "35"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Seguridad de minoxidil oral a dosis bajas en pacientes con hipertensi&#243;n o arritmias&#58; estudio multic&#233;ntrico de 264 pacientes"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0015"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 793
              "Ancho" => 1333
              "Tamanyo" => 160949
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Jimenez-Cauhe, R&#46; Pirmez, P&#46; M&#252;ller-Ramos, D&#46;F&#46; Melo, D&#46; Ortega-Quijano, O&#46;M&#46; Moreno-Arrones, D&#46; Saceda-Corralo, R&#46; Gil-Redondo, A&#46; Hermosa-Gelbard, B&#46; Dias-Sanabria, D&#46; Restom, M&#46;L&#46; Porri&#241;o-Bustamante, C&#46; Pindado-Ortega, E&#46; Berna-Rico, D&#46; Fernandez-Nieto, M&#46; Ramos, P&#46; Jaen-Olasolo, S&#46; Va&#241;o-Galvan"
          "autores" => array:18 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Jimenez-Cauhe"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Pirmez"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "M&#252;ller-Ramos"
            ]
            3 => array:2 [
              "nombre" => "D&#46;F&#46;"
              "apellidos" => "Melo"
            ]
            4 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ortega-Quijano"
            ]
            5 => array:2 [
              "nombre" => "O&#46;M&#46;"
              "apellidos" => "Moreno-Arrones"
            ]
            6 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Saceda-Corralo"
            ]
            7 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Gil-Redondo"
            ]
            8 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Hermosa-Gelbard"
            ]
            9 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Dias-Sanabria"
            ]
            10 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Restom"
            ]
            11 => array:2 [
              "nombre" => "M&#46;L&#46;"
              "apellidos" => "Porri&#241;o-Bustamante"
            ]
            12 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Pindado-Ortega"
            ]
            13 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Berna-Rico"
            ]
            14 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Fernandez-Nieto"
            ]
            15 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Ramos"
            ]
            16 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Jaen-Olasolo"
            ]
            17 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Va&#241;o-Galvan"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0015"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023006798?idApp=UINPBA000044"
    "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023006798/v1_202401030514/en/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:18 [
      "pii" => "S0001731023006798"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2023.07.019"
      "estado" => "S300"
      "fechaPublicacion" => "2024-01-01"
      "aid" => "3624"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Actas Dermosifiliogr. 2024;115:28-35"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:14 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia&#58; A Multicenter Study of 264 Patients"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:3 [
          0 => "en"
          1 => "en"
          2 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "28"
            "paginaFinal" => "35"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Seguridad de minoxidil oral a dosis bajas en pacientes con hipertensi&#243;n o arritmias&#58; estudio multic&#233;ntrico de 264 pacientes"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 1
          "multimedia" => array:5 [
            "identificador" => "fig0015"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => false
            "mostrarDisplay" => true
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "fx1.jpeg"
                "Alto" => 793
                "Ancho" => 1333
                "Tamanyo" => 160949
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Jimenez-Cauhe, R&#46; Pirmez, P&#46; M&#252;ller-Ramos, D&#46;F&#46; Melo, D&#46; Ortega-Quijano, O&#46;M&#46; Moreno-Arrones, D&#46; Saceda-Corralo, R&#46; Gil-Redondo, A&#46; Hermosa-Gelbard, B&#46; Dias-Sanabria, D&#46; Restom, M&#46;L&#46; Porri&#241;o-Bustamante, C&#46; Pindado-Ortega, E&#46; Berna-Rico, D&#46; Fernandez-Nieto, M&#46; Ramos, P&#46; Jaen-Olasolo, S&#46; Va&#241;o-Galvan"
            "autores" => array:18 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Jimenez-Cauhe"
              ]
              1 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Pirmez"
              ]
              2 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "M&#252;ller-Ramos"
              ]
              3 => array:2 [
                "nombre" => "D&#46;F&#46;"
                "apellidos" => "Melo"
              ]
              4 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ortega-Quijano"
              ]
              5 => array:2 [
                "nombre" => "O&#46;M&#46;"
                "apellidos" => "Moreno-Arrones"
              ]
              6 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Saceda-Corralo"
              ]
              7 => array:2 [
                "nombre" => "R&#46;"
                "apellidos" => "Gil-Redondo"
              ]
              8 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Hermosa-Gelbard"
              ]
              9 => array:2 [
                "nombre" => "B&#46;"
                "apellidos" => "Dias-Sanabria"
              ]
              10 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Restom"
              ]
              11 => array:2 [
                "nombre" => "M&#46;L&#46;"
                "apellidos" => "Porri&#241;o-Bustamante"
              ]
              12 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Pindado-Ortega"
              ]
              13 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Berna-Rico"
              ]
              14 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Fernandez-Nieto"
              ]
              15 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Ramos"
              ]
              16 => array:2 [
                "nombre" => "P&#46;"
                "apellidos" => "Jaen-Olasolo"
              ]
              17 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Va&#241;o-Galvan"
              ]
            ]
          ]
        ]
        "resumen" => array:1 [
          0 => array:3 [
            "titulo" => "Graphical abstract"
            "clase" => "graphical"
            "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0015"></elsevierMultimedia></p></span>"
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023006798?idApp=UINPBA000044"
      "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023006798/v1_202401030514/en/main.assets"
    ]
  ]
  "es" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
    "titulo" => "&#91;Art&#237;ulo traducido&#93; Seguridad de minoxidil oral a dosis bajas en pacientes con hipertensi&#243;n o arritmias&#58; estudio multic&#233;ntrico de 264 pacientes"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T28"
        "paginaFinal" => "T35"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Jimenez-Cauhe, R&#46; Pirmez, P&#46; M&#252;ller-Ramos, D&#46;F&#46; Melo, D&#46; Ortega-Quijano, O&#46;M&#46; Moreno-Arrones, D&#46; Saceda-Corralo, R&#46; Gil-Redondo, A&#46; Hermosa-Gelbard, B&#46; Dias-Sanabria, D&#46; Restom, M&#46;L&#46; Porri&#241;o-Bustamante, C&#46; Pindado-Ortega, E&#46; Berna-Rico, D&#46; Fernandez-Nieto, M&#46; Ramos, P&#46; Jaen-Olasolo, S&#46; Va&#241;o-Galvan"
        "autores" => array:18 [
          0 => array:3 [
            "nombre" => "J&#46;"
            "apellidos" => "Jimenez-Cauhe"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Pirmez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "M&#252;ller-Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff0020"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "D&#46;F&#46;"
            "apellidos" => "Melo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff0025"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ortega-Quijano"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "O&#46;M&#46;"
            "apellidos" => "Moreno-Arrones"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          6 => array:4 [
            "nombre" => "D&#46;"
            "apellidos" => "Saceda-Corralo"
            "email" => array:1 [
              0 => "d.saceda@gmail.com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "R&#46;"
            "apellidos" => "Gil-Redondo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">f</span>"
                "identificador" => "aff0030"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Hermosa-Gelbard"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "B&#46;"
            "apellidos" => "Dias-Sanabria"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">g</span>"
                "identificador" => "aff0035"
              ]
            ]
          ]
          10 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Restom"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          11 => array:3 [
            "nombre" => "M&#46;L&#46;"
            "apellidos" => "Porri&#241;o-Bustamante"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          12 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Pindado-Ortega"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          13 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Berna-Rico"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          14 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Fernandez-Nieto"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          15 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Ramos"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">h</span>"
                "identificador" => "aff0040"
              ]
            ]
          ]
          16 => array:3 [
            "nombre" => "P&#46;"
            "apellidos" => "Jaen-Olasolo"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          17 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Va&#241;o-Galvan"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:8 [
          0 => array:3 [
            "entidad" => "Dermatology Department&#44; Hospital Universitario Ramon y Cajal&#44; IRYCIS&#44; Universidad de Alcala&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Trichology Unit&#44; Grupo de Dermatologia Pedro Jaen&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Instituto de Dermatologia Professor Rubem David Azulay&#44; Santa Casa de Miseric&#243;rdia do Rio de Janeiro&#44; Rio de Janeiro&#44; Brazil"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
          3 => array:3 [
            "entidad" => "Universidade Estadual Paulista &#8211; UNESP&#44; Botucatu&#44; S&#227;o Paulo&#44; Brazil"
            "etiqueta" => "d"
            "identificador" => "aff0020"
          ]
          4 => array:3 [
            "entidad" => "Dermatology Department&#44; University of State of Rio de Janeiro &#40;UERJ&#41;&#44; Spain"
            "etiqueta" => "e"
            "identificador" => "aff0025"
          ]
          5 => array:3 [
            "entidad" => "Dermatology Department&#44; Hospital Universitario La Paz&#44; Madrid&#44; Spain"
            "etiqueta" => "f"
            "identificador" => "aff0030"
          ]
          6 => array:3 [
            "entidad" => "Universidade Federal do Mato Grosso do Sul&#44; Campo Grande&#44; Mato Grosso do Sul&#44; Brazil"
            "etiqueta" => "g"
            "identificador" => "aff0035"
          ]
          7 => array:3 [
            "entidad" => "Cardiology Department&#44; Hospital Universitario de la Cruz Roja San Jose y Santa Adela&#44; Universidad Alfonso X El Sabio&#44; Madrid&#44; Spain"
            "etiqueta" => "h"
            "identificador" => "aff0040"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Safety of Low-Dose Oral Minoxidil in Patients With Hypertension and Arrhythmia&#58; A Multicenter Study of 264 Patients"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 1
      "multimedia" => array:5 [
        "identificador" => "fig0015"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 840
            "Ancho" => 1333
            "Tamanyo" => 152060
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El minoxidil es un vasodilatador arteriolar aprobado en la d&#233;cada de 1970 como tratamiento de la hipertensi&#243;n refractaria grave&#44; con una dosis est&#225;ndar que oscilan entre 10 y 40<span class="elsevierStyleHsp" style=""></span>mg diarios &#40;hasta 100<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#237;a&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a>&#46; En los &#250;ltimos a&#241;os&#44; el minoxidil oral a dosis bajas &#40;MODB&#41; se ha utilizado cada vez con mayor frecuencia en el tratamiento de distintos tipos de alopecia&#44; teniendo el respaldo de numerosos estudios que describen su eficacia y su perfil de seguridad favorable<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#44;3</span></a>&#46; Uno de los estudios m&#225;s amplios describi&#243; exhaustivamente la frecuencia y cronolog&#237;a de los efectos adversos &#40;EA&#41; del tratamiento con MODB en 1404 pacientes<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a>&#46; La hipertricosis es un EA bien conocido y el m&#225;s frecuente de MODB y se presentar&#225; en aproximadamente el 15&#37; de los pacientes<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;5</span></a>&#46; Aunque son infrecuentes&#44; pueden producirse EA sist&#233;micos que&#44; en una minor&#237;a de pacientes&#44; conducen a la interrupci&#243;n del tratamiento con MODB&#46; La mayor&#237;a de los EA sist&#233;micos est&#225;n relacionados con el efecto cardiovascular y hemodin&#225;mico del minoxidil&#44; incluyendo la presencia de mareos &#40;v&#233;rtigo&#44; hipotensi&#243;n postural&#41;&#44; retenci&#243;n de l&#237;quidos &#40;edema de miembros inferiores o facial&#41;&#44; taquicardia &#40;palpitaciones&#41;&#44; alteraciones del electrocardiograma &#40;principalmente en la onda T&#41;&#44; cefalea&#44; insomnio&#44; pesadillas o aumento del apetito<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;4&#44;6&#44;7</span></a>&#46; Estos EA son generalmente bien tolerados y se resuelven tras la interrupci&#243;n o el ajuste de la dosis del MODB&#46; Se han notificado EA graves con dosis altas de minoxidil oral cuando se utiliza para la hipertensi&#243;n grave o debido a errores de composici&#243;n en el tratamiento de la ca&#237;da del cabello&#44; incluyendo s&#237;ncope hipotensor&#44; pericarditis&#44; derrame peric&#225;rdico o infarto de miocardio<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">1&#44;8</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Los EA sist&#233;micos representan la principal preocupaci&#243;n del tratamiento con MODB en la poblaci&#243;n general con p&#233;rdida de cabello&#44; que en su mayor&#237;a son adultos sanos de mediana edad&#46; Teniendo en cuenta que el MODB se utiliza como un tratamiento que est&#225; fuera de ficha t&#233;cnica&#44; estos problemas de seguridad adquieren mayor importancia cuando se prescribe en situaciones especiales&#44; como pacientes con antecedentes personales de hipertensi&#243;n arterial &#40;HTA&#41; o arritmia&#46; A&#250;n se desconoce si el MODB podr&#237;a potenciar el efecto hipotensor de otros f&#225;rmacos antihipertensivos o aumentar el riesgo de EA sist&#233;micos en estos pacientes&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El objetivo de este estudio fue evaluar la seguridad del MODB en el tratamiento de la ca&#237;da del cabello en pacientes con HTA o arritmia&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">M&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Este estudio de tipo retrospectivo&#44; descriptivo y multic&#233;ntrico incluy&#243; pacientes adultos con antecedentes personales de HTA o arritmia que estaban en tratamiento con MODB para la p&#233;rdida de cabello de cualquier causa durante al menos un mes&#59; los pacientes se incluyeron a partir de cinco centros de Brasil y Espa&#241;a&#44; desde enero de 2018 hasta abril de 2022&#46; La duraci&#243;n m&#237;nima del tratamiento de un mes se estableci&#243; teniendo en cuenta la cronolog&#237;a de los EA de MODB previamente descrita<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a>&#46; Los datos epidemiol&#243;gicos&#44; m&#233;dicos y de seguridad se recogieron de los registros m&#233;dicos de los pacientes&#44; incluidos los tratamientos previos para la HTA&#44; los EA y la necesidad de retirar o ajustar la dosis de MODB o los tratamientos antihipertensivos&#46; En algunos pacientes&#44; la dosis de MODB se titul&#243; en funci&#243;n de la respuesta y la tolerabilidad&#44; y los par&#225;metros anteriores se analizaron para cada dosis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El an&#225;lisis estad&#237;stico se realiz&#243; con IBM SPSS Statistics &#40;Versi&#243;n 25&#46;0&#58; IBM Corp&#46;&#44; 2017&#41;&#46; Las variables continuas se expresaron como media &#40;rango&#41;&#46; Se utiliz&#243; la regresi&#243;n log&#237;stica para identificar las variables asociadas con un mayor riesgo de EA sist&#233;micos&#44; suspensi&#243;n o ajuste de los tratamientos con MODB o antihipertensivos&#44; que se consideraron estad&#237;sticamente significativas si el valor P era<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Hipertensi&#243;n</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se incluyeron 254 pacientes &#91;176 mujeres &#40;69&#44;3&#37;&#41; y 78 hombres &#40;30&#44;7&#37;&#41;&#93; con una edad media de 56&#44;9 a&#241;os &#40;rango 19-82&#41;&#46; De ellos&#44; se titul&#243; la dosis de MODB en varias dosis increment&#225;ndolas seg&#250;n la tolerancia en 82 pacientes &#40;32&#44;2&#37;&#41;&#44; lo que permiti&#243; analizar 382 dosis diferentes&#46; La dosis media de MODB fue de 1&#44;59<span class="elsevierStyleHsp" style=""></span>mg &#40;rango 0&#44;2-10&#41; y la duraci&#243;n media fue de 10&#44;9 meses &#40;1-51&#41;&#46; El MODB fue la &#250;nica terapia sist&#233;mica para la ca&#237;da del cabello en 124 pacientes &#40;48&#44;8&#37;&#41;&#46; En los pacientes restantes&#44; el f&#225;rmaco concomitante m&#225;s frecuente fue la dutasterida oral&#46; La indicaci&#243;n m&#225;s frecuente para el tratamiento con MODB fue la alopecia androgen&#233;tica &#40;68&#44;9&#37;&#41;&#44; seguida de la alopecia frontal fibrosante &#40;10&#44;2&#37;&#41;&#44; el efluvio tel&#243;geno &#40;4&#44;3&#37;&#41;&#44; el liquen plano pilar &#40;3&#44;5&#37;&#41;&#44; la alopecia fibrosante en patr&#243;n de distribuci&#243;n &#40;3&#44;1&#37;&#41;&#44; la alopecia areata &#40;2&#44;4&#37;&#41; y otros tipos de alopecia menos frecuentes&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Antes del tratamiento con MODB&#44; los pacientes recib&#237;an una media de 1&#44;4 f&#225;rmacos antihipertensivos &#40;rango 0-5&#41;&#46; S&#243;lo 5 pacientes &#40;1&#44;3&#37;&#41; no recib&#237;an tratamiento para la HTA&#46; La clase de f&#225;rmacos m&#225;s frecuente fueron los antagonistas de los receptores de la angiotensina II &#40;ARA-II&#41; en 190 pacientes &#40;49&#44;7&#37;&#41;&#44; seguidos de las tiazidas &#40;28&#44;5&#37;&#41;&#44; los betabloqueantes &#40;28&#37;&#41; y otros &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Se detectaron EA en 71 pacientes &#40;27&#44;9&#37;&#41; con 84 dosis &#40;21&#44;9&#37;&#41;&#46; El EA m&#225;s frecuente fue la hipertricosis en 49 pacientes &#40;19&#44;2&#37;&#41; con 61 dosis &#40;15&#44;9&#37;&#41;&#44; dado que 7 pacientes &#40;2&#44;7&#37;&#41; desarrollaron hipertricosis con varias dosis&#46; Se identificaron EA sist&#233;micos en 23 pacientes &#40;9&#37;&#41; con 26 dosis &#40;6&#44;8&#37;&#41; y entre estos se incluyeron los mareos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12&#59; 3&#46; 1&#37;&#41;&#44; la retenci&#243;n de l&#237;quidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>10&#59; 2&#44;6&#37;&#41;&#44; el malestar general &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#59; 0&#44;8&#37;&#41;&#44; taquicardia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#59; 0&#44;8&#37;&#41; y cefalea &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#59; 0&#44;5&#37;&#41;&#46; Cinco pacientes &#40;1&#44;9&#37;&#41; desarrollaron m&#225;s de un EA&#58; hipertricosis m&#225;s mareo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; hipertricosis m&#225;s taquicardia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; mareo m&#225;s malestar general &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; y mareo m&#225;s malestar general m&#225;s retenci&#243;n de l&#237;quidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44; que requiri&#243; la interrupci&#243;n del MODB&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Todos los EA mejoraron con el ajuste de la dosis o la interrupci&#243;n del f&#225;rmaco&#44; y no se observaron EA potencialmente mortales&#46; La dosis de MODB se redujo en 14 casos &#40;3&#44;6&#37;&#41;&#44; de los cuales 8 se debieron a EA sist&#233;micos y 6 a hipertricosis&#46; Fue necesario interrumpir el tratamiento con MODB en 6 casos &#40;1&#46; 5&#37;&#41; debido a una intensa ca&#237;da del cabello &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; retenci&#243;n de l&#237;quidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; mareos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; mareos m&#225;s malestar general &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; mareo&#44; malestar general m&#225;s retenci&#243;n de l&#237;quidos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; y taquicardia m&#225;s hipertricosis &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#59; este paciente interrumpi&#243; el MODB por taquicardia&#44; luego reinici&#243; el tratamiento sin EA sist&#233;micos&#44; y volvi&#243; a interrumpirlo al cabo de 1 a&#241;o por hipertricosis&#41;&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">El EA m&#225;s frecuente que condujo al ajuste o la retirada de la MODB fue el mareo &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>7&#59; P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; La hipertricosis se asoci&#243; con un mayor riesgo de ajuste de la dosis &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41;&#44; pero no con la interrupci&#243;n &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;65&#41;&#46; La edad&#44; el sexo y la dosis de MODB no se asociaron con el riesgo de EA sist&#233;micos ni con el ajuste de MODB&#46; Otros factores asociados con el ajuste y la retirada de MODB se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Los pacientes que recib&#237;an 3 o m&#225;s f&#225;rmacos antihipertensivos ten&#237;an mayor riesgo de desarrollar m&#225;s de 1 EA &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; mareo &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; malestar general &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; y de requerir la interrupci&#243;n del MODB &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;012&#41;&#46; Asimismo&#44; el tratamiento previo con doxazosina se asoci&#243; a un mayor riesgo de mareo &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; malestar general &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#44; retenci&#243;n de l&#237;quidos &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41; y necesidad tanto de ajustar la dosis &#40;P<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;006&#41; como de retirar el MODB &#40;P<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">En cuanto al tratamiento antihipertensivo&#44; s&#243;lo dos pacientes &#40;0&#44;7&#37;&#41; requirieron un ajuste o la interrupci&#243;n de su tratamiento previo&#46; Una mujer de 67 a&#241;os tratada con minoxidil 0&#44;5<span class="elsevierStyleHsp" style=""></span>mg y espironolactona 50<span class="elsevierStyleHsp" style=""></span>mg diarios&#44; desarroll&#243; hipotensi&#243;n sintom&#225;tica cuatro d&#237;as despu&#233;s de cambiar de ramipril a olmesart&#225;n &#40;por su m&#233;dico de cabecera&#41;&#46; Se suspendi&#243; el olmesart&#225;n y se control&#243; la HTA con minoxidil y espironolactona&#46; La otra paciente era una mujer de 71 a&#241;os cuyo tratamiento previo con losart&#225;n se suspendi&#243; debido al buen control de su HTA con minoxidil 2&#44;5<span class="elsevierStyleHsp" style=""></span>mg diarios&#46; El resto de pacientes no refirieron cambios o alteraciones de su HTA durante el tratamiento con MODB&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Arritmia</span><p id="par0065" class="elsevierStylePara elsevierViewall">Se incluyeron un total de 10 pacientes &#40;8 mujeres y 2 hombres&#41; con una mediana de edad de 61 a&#241;os &#40;rango 37-74&#41;&#46; De ellos&#44; se titul&#243; la dosis de MODB en tres pacientes&#44; lo que permiti&#243; analizar 15 dosis&#46; La mediana de la dosis de MODB fue de 0&#44;75<span class="elsevierStyleHsp" style=""></span>mg &#40;rango 0&#44;25-5&#41; y la mediana de la duraci&#243;n fue de 5 meses &#40;rango 1-11&#41;&#46; La indicaci&#243;n m&#225;s frecuente para el tratamiento con MODB fue la alopecia androgen&#233;tica &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#41;&#44; seguida del efluvio tel&#243;geno cr&#243;nico &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; y la alopecia frontal fibrosante &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#46; Nueve pacientes ten&#237;an antecedentes personales de arritmia&#44; entre ellas&#44; extras&#237;stole supraventricular &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41;&#44; fibrilaci&#243;n auricular &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; taquicardia sinusal &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; s&#237;ncope cardiaco &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41; y arritmia desconocida &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#44; faltaban datos&#41;&#46; De ellos&#44; cuatro pacientes estaban bajo tratamiento m&#233;dico con betabloqueantes &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3&#41; o amiodarona &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#44; dos pacientes se hab&#237;an sometido a una ablaci&#243;n card&#237;aca&#44; un paciente ten&#237;a un marcapasos y dos pacientes no recib&#237;an ning&#250;n tratamiento&#46; El paciente restante ten&#237;a una v&#225;lvula a&#243;rtica mec&#225;nica debido a un aneurisma a&#243;rtico reparado por el procedimiento de Bentall&#46; De estos 10 pacientes&#44; en cinco de ellos se realiz&#243; una consulta con el cardi&#243;logo antes de iniciar el tratamiento con MODB&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">S&#243;lo se notificaron EA sist&#233;micos en un paciente con extras&#237;stole supraventricular en tratamiento con carvedilol que desarroll&#243; edema periorbitario y de pies con MODB 1<span class="elsevierStyleHsp" style=""></span>mg&#44; que se resolvi&#243; tras ajustar la dosis a 0&#44;25<span class="elsevierStyleHsp" style=""></span>mg&#46; Ning&#250;n paciente notific&#243; palpitaciones&#44; empeoramiento de su arritmia previa ni ning&#250;n otro EA cardiol&#243;gico&#44; y ninguno de ellos requiri&#243; una modificaci&#243;n de su tratamiento m&#233;dico previo&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Hasta donde sabemos&#44; &#233;ste representa el primer estudio sobre la seguridad del MODB en pacientes con HTA o arritmia&#46; Numerosos estudios han demostrado su perfil de seguridad favorable en poblaci&#243;n general<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#8211;4&#44;6</span></a> y estudios recientes han investigado el uso de MODB en situaciones especiales como en la poblaci&#243;n pedi&#225;trica<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">9</span></a>&#44; adolescente<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">10</span></a> y anciana<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">11</span></a>&#44; pero hay escasos datos de su uso en pacientes con HTA o arritmia&#46; La prevalencia global de HTA en adultos es del 34&#37;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">12</span></a>&#44; por lo que parece importante ampliar el conocimiento sobre el manejo y los aspectos de seguridad del tratamiento con el MODB en estos pacientes&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">En nuestra cohorte de pacientes hipertensos tratados con el MODB&#44; la frecuencia global y el tipo de EA fueron consistentes con los encontrados en estudios recientes<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46; Se detectaron EA en el 21&#44;9&#37; de los casos&#44; y la hipertricosis fue el m&#225;s frecuente &#40;15&#44;9&#37;&#41;&#44; de forma similar a los datos encontrados por Va&#241;o-Galv&#225;n et al<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">4</span></a>&#46; Sin embargo&#44; encontramos una mayor frecuencia de EA cardiovasculares &#40;mareo y retenci&#243;n de l&#237;quidos&#41;&#44; y m&#225;s pacientes que presentaron m&#225;s de 1 EA &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">El mareo y la taquicardia se asociaron significativamente con un mayor riesgo tanto de ajuste como de suspensi&#243;n del MODB &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La hipertricosis se asoci&#243; al ajuste de dosis pero no a la suspensi&#243;n&#44; lo que apoya que este EA suele ser bien tolerado&#46; Los pacientes tratados con tres o m&#225;s f&#225;rmacos antihipertensivos presentaron un mayor riesgo de mareo y de suspensi&#243;n del MODB&#46; Entre todos los f&#225;rmacos antihipertensivos&#44; la doxazosina provoc&#243; un mayor riesgo de mareo&#44; retenci&#243;n de l&#237;quidos y suspensi&#243;n del MODB&#46; Esto podr&#237;a explicarse por el hecho de que la doxazosina es un bloqueante alfaadren&#233;rgico que tambi&#233;n provoca vasodilataci&#243;n arteriolar<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">13</span></a>&#44; lo que podr&#237;a producir un efecto sin&#233;rgico con el minoxidil&#46; Aunque podr&#237;a ser plausible que otros vasodilatadores&#44; como la hidralazina o los antagonistas del calcio&#44; aumentaran este efecto sin&#233;rgico con el minoxidil&#44; no encontramos una asociaci&#243;n estad&#237;sticamente significativa&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">El mareo &#40;tambi&#233;n denominado v&#233;rtigo o hipotensi&#243;n postural&#41; fue el EA sist&#233;mico m&#225;s frecuente y la causa m&#225;s com&#250;n tanto de ajuste como de interrupci&#243;n del MODB &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#41;&#46; En general fue leve y se notific&#243; con mayor frecuencia en verano y por la ma&#241;ana&#46; No hubo casos de hipotensi&#243;n grave ni de alteraci&#243;n del control de la presi&#243;n arterial &#40;PA&#41;&#46; A este respecto&#44; dos estudios recientes investigaron la variaci&#243;n de la PA en pacientes varones tratados con 5<span class="elsevierStyleHsp" style=""></span>mg de MODB mediante monitorizaci&#243;n ambulatoria de la PA durante 24<span class="elsevierStyleHsp" style=""></span>h&#46; Encontraron una ligera reducci&#243;n de la PA en las 2<span class="elsevierStyleHsp" style=""></span>h posteriores a la toma de MODB <a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">14</span></a> y en la semana 24<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a>&#46; Pocos estudios adicionales han evaluado la PA durante el tratamiento con MODB a dosis entre 0&#44;45 y 5<span class="elsevierStyleHsp" style=""></span>mg&#44; obteniendo resultados similares<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">15&#8211;17</span></a>&#46; Esto concuerda con estudios de los a&#241;os setenta con minoxidil de 2&#44;5<span class="elsevierStyleHsp" style=""></span>mg&#44; 5<span class="elsevierStyleHsp" style=""></span>mg y 10<span class="elsevierStyleHsp" style=""></span>mg que encontraron un efecto hipotensor m&#237;nimo o nulo en pacientes normotensos<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">18</span></a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">La retenci&#243;n de l&#237;quidos &#40;principalmente edema de pies&#59; s&#243;lo 2 casos de edema facial&#41; se detect&#243; en nuestro estudio en el 2&#44;6&#37; de los pacientes&#44; lo que supone una frecuencia ligeramente superior a la de estudios previos en poblaci&#243;n general<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">3&#44;4</span></a>&#44; pero muy inferior al tratamiento con dosis est&#225;ndar &#40;7&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a>&#46; No encontramos una frecuencia inferior en los pacientes que tomaban diur&#233;ticos como antihipertensivos &#40;tiazidas o espironolactona&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">La taquicardia solo se detect&#243; en el 0&#44;8&#37; de los pacientes con hipertensi&#243;n arterial&#44; requiriendo todos ellos ajuste o suspensi&#243;n del MODB&#46; La taquicardia es el resultado de una activaci&#243;n simp&#225;tica refleja inducida por el efecto vasodilatador del minoxidil oral&#44; y tradicionalmente se describe como un EA frecuente con la dosis est&#225;ndar<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a>&#46; Sin embargo&#44; los estudios con el MODB han demostrado que las palpitaciones son bastante infrecuentes y transitorias&#44; apareciendo generalmente dentro de las primeras tomas del MODB<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">4&#44;7&#44;15&#44;17</span></a>&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Los cambios en el electrocardiograma son otro EA com&#250;n con la dosis est&#225;ndar de minoxidil&#44; presentando cambios en la direcci&#243;n y en la magnitud de las ondas T hasta en el 60&#37; de los pacientes&#44; debido principalmente a un mecanismo de robo coronario asociado a la reducci&#243;n de la presi&#243;n arterial en las arterias coronarias&#46; Son asintom&#225;ticas y suelen desaparecer a pesar de la continuaci&#243;n del tratamiento<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">1</span></a>&#46; Solo en pocos estudios se han realizado electrocardiogramas en pacientes con MODB&#46; Un estudio realizado en Tailandia encontr&#243; cambios asintom&#225;ticos en la onda T en el 10-20&#37; de los pacientes &#40;inversi&#243;n de la onda T no isqu&#233;mica en una derivaci&#243;n&#41;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">15</span></a>&#46; Sanabria et al&#46; encontraron un aumento no significativo en la aparici&#243;n de extras&#237;stole supraventricular y ventricular despu&#233;s de 24 semanas de tratamiento con 5<span class="elsevierStyleHsp" style=""></span>mg del MODB&#44; sin alteraciones notables en la repolarizaci&#243;n ventricular en la monitorizaci&#243;n Holter de 24<span class="elsevierStyleHsp" style=""></span>h<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">De manera interesante&#44; en esta cohorte de pacientes con arritmia&#44; ning&#250;n paciente inform&#243; palpitaciones o empeoramiento de su enfermedad previa&#46; A estos pacientes no se les realiz&#243; un electrocardiograma de rutina&#44; pero cinco de ellos fueron remitidos a su cardi&#243;logo&#44; quien aprob&#243; el tratamiento con MODB&#46; Sin embargo&#44; se debe extremar la precauci&#243;n en pacientes con enfermedad coronaria o insuficiencia card&#237;aca cr&#243;nica&#44; ya que la taquicardia puede limitar la oxigenaci&#243;n del miocardio &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">De manera consistente con aquellos estudios previos de MODB&#44; no se detect&#243; ning&#250;n EA cardiovascular grave&#44; como la presencia de s&#237;ncopes&#44; cardiopat&#237;a isqu&#233;mica&#44; pericarditis o derrame peric&#225;rdico&#46; Estos EA se describieron con dosis est&#225;ndar de minoxidil&#44; pero ocurrieron principalmente en pacientes con enfermedades de base como el lupus eritematoso sist&#233;mico&#44; la enfermedad renal avanzada o insuficiencia card&#237;aca congestiva&#44; y son extremadamente raros con el MODB<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">19&#44;20</span></a>&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Bas&#225;ndonos en nuestros resultados&#44; la experiencia cl&#237;nica de los autores en el tratamiento del MODB y la colaboraci&#243;n de un cardi&#243;logo en este estudio &#40;MR&#41;&#44; la mayor&#237;a de los pacientes sometidos a tratamiento para la HTA pueden iniciar MODB sin necesidad de derivaci&#243;n previa al cardi&#243;logo&#46; Sin embargo&#44; sugerimos algunas recomendaciones para el manejo de la terapia MODB en pacientes con HTA o arritmia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Las limitaciones de este estudio fueron el dise&#241;o retrospectivo&#44; la ausencia de un grupo control y la ausencia de la medici&#243;n objetiva de la presi&#243;n arterial y la realizaci&#243;n de ECG&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; el tratamiento con el MODB demostr&#243; un perfil de seguridad favorable en pacientes con HTA o arritmia&#44; similar al de la poblaci&#243;n general&#46; Los EA sist&#233;micos m&#225;s frecuentes fueron el mareo y la retenci&#243;n de l&#237;quidos&#44; que mejoraron tras el ajuste o la retirada del MODB&#46; La combinaci&#243;n de MODB con 3 o m&#225;s f&#225;rmacos antihipertensivos o con doxazosina se asoci&#243; con un mayor riesgo de estos EA sist&#233;micos&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0135" class="elsevierStylePara elsevierViewall">Los autores declaran que no tienen ning&#250;n conflicto de intereses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:11 [
        0 => array:3 [
          "identificador" => "xres2067363"
          "titulo" => "Graphical abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:3 [
          "identificador" => "xres2067364"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Antecedentes y objetivo"
            ]
            1 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Material y m&#233;todo"
            ]
            2 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        2 => array:2 [
          "identificador" => "xpalclavsec1764142"
          "titulo" => "Palabras clave"
        ]
        3 => array:3 [
          "identificador" => "xres2067365"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Background and objective"
            ]
            1 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Patients and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0045"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "xpalclavsec1764141"
          "titulo" => "Keywords"
        ]
        5 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introducci&#243;n"
        ]
        6 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "M&#233;todos"
        ]
        7 => array:3 [
          "identificador" => "sec0015"
          "titulo" => "Resultados"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Hipertensi&#243;n"
            ]
            1 => array:2 [
              "identificador" => "sec0025"
              "titulo" => "Arritmia"
            ]
          ]
        ]
        8 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Discusi&#243;n"
        ]
        9 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Conflicto de intereses"
        ]
        10 => array:1 [
          "titulo" => "Referencias"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2023-06-23"
    "fechaAceptado" => "2023-07-20"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1764142"
          "palabras" => array:7 [
            0 => "Alopecia androg&#233;nica"
            1 => "Hipotensi&#243;n"
            2 => "Hipertensi&#243;n arterial"
            3 => "Presi&#243;n arterial"
            4 => "Alopecia"
            5 => "Arritmia"
            6 => "Cardiopat&#237;a"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1764141"
          "palabras" => array:7 [
            0 => "Androgenetic alopecia"
            1 => "Hypotension"
            2 => "Arterial hypertension"
            3 => "Blood pressure"
            4 => "Hair loss"
            5 => "Arrhythmia"
            6 => "Heart disease"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Antecedentes y objetivo</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los efectos adversos sist&#233;micos son una de las principales limitaciones del uso de minoxidil oral a dosis bajas &#40;MODB&#41;&#44; especialmente en pacientes con hipertensi&#243;n arterial o arritmias&#46; El objetivo de este estudio fue evaluar la seguridad de MODB en estos pacientes&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todo</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo multic&#233;ntrico con pacientes con antecedentes de hipertensi&#243;n o arritmias tratados con MODB para cualquier tipo de alopecia&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; un total de 254 pacientes con hipertensi&#243;n &#40;176 mujeres &#91;69&#44;3&#37;&#93; y 78 hombres &#91;30&#44;7&#37;&#93;&#41; con una edad media de 56&#44;9 a&#241;os &#40;rango 19 &#8211; 82&#41;&#46; La dosis de MODB se increment&#243; gradualmente en 128 pacientes&#44; obteniendo un total de 382 dosis analizadas&#46; Los sujetos estaban tomando de media 1&#44;45 f&#225;rmacos antihipertensivos &#40;rango 0 &#8211; 5&#41;&#46; Se detectaron EA sist&#233;micos en 26 casos &#40;6&#44;8&#37;&#41;&#44; incluyendo mareo &#40;3&#44;1&#37;&#41;&#44; retenci&#243;n de l&#237;quidos &#40;2&#44;6&#37;&#41;&#44; malestar general &#40;0&#44;8&#37;&#41;&#44; taquicardia &#40;0&#44;8&#37;&#41; y cefalea &#40;0&#44;5&#37;&#41;&#44; requiriendo suspensi&#243;n del MODB en seis casos &#40;1&#44;5&#37;&#41;&#46; Los pacientes en tratamiento con doxazosina &#40;p &#60; 0&#44;001&#41; o con tres o m&#225;s antihipertensivos &#40;p &#61; 0&#44;012&#41; presentaron mayor riesgo de suspensi&#243;n de MODB&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusi&#243;n</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El tratamiento con MODB mostr&#243; un perfil de seguridad favorable en pacientes con hipertensi&#243;n o arritmias&#44; similar al de la poblaci&#243;n general&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Antecedentes y objetivo"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material y m&#233;todo"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Background and objective</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Systemic adverse effects &#40;AE&#41; are a major concern of low-dose oral minoxidil &#40;LDOM&#41; treatment&#44; especially in patients with arterial hypertension or arrhythmia&#46; The objective of this study was to evaluate the safety of LDOM in patients with hypertension or arrhythmia&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Patients and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Retrospective multicenter study of patients with hypertension or arrhythmia treated with LDOM for any type of alopecia&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A total of 254 patients with hypertension &#91;176 women &#40;69&#46;3&#37;&#41; and 78 men &#40;30&#46;7&#37;&#41;&#93; with a mean age of 56&#46;9 years &#40;range 19&#8211;82&#41; were included&#46; From them&#44; the dose of LDOM was titrated in 128 patients&#44; allowing the analysis of 382 doses&#46; Patients were receiving a mean of 1&#46;45 &#40;range 0&#8211;5&#41; antihypertensive drugs&#46; Systemic AE were detected in 26 cases &#40;6&#46;8&#37;&#41; and included lightheadedness &#40;3&#46;1&#37;&#41;&#44; fluid retention &#40;2&#46;6&#37;&#41;&#44; general malaise &#40;0&#46;8&#37;&#41;&#44; tachycardia &#40;0&#46;8&#37;&#41; and headache &#40;0&#46;5&#37;&#41;&#44; leading to LDOM discontinuation in 6 cases &#40;1&#46;5&#37;&#41;&#46; Prior treatment with doxazosin &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#44; or with three or more antihypertensive drugs &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#41; was associated with a higher risk of discontinuation of LDOM&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">LDOM treatment showed a favorable safety profile in patients with hypertension or arrhythmia&#44; similar to general population&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Background and objective"
          ]
          1 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Patients and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1248
            "Ancho" => 2516
            "Tamanyo" => 312086
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Diagrama de flujo que describe el tipo y la frecuencia de los efectos adversos&#44; el ajuste de la dosis y la interrupci&#243;n del tratamiento con MODB en pacientes hipertensos&#46;&#42; La suma de las frecuencias individuales puede diferir de la frecuencia total porque algunos pacientes desarrollaron m&#225;s de un efecto adverso&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2355
            "Ancho" => 2518
            "Tamanyo" => 734609
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Recomendaciones para el manejo de la terapia con MODB en pacientes con hipertensi&#243;n o arritmia &#40;basadas en la experiencia cl&#237;nica de los autores y los resultados de este estudio&#41;&#46; <span class="elsevierStyleSup">a</span> Comentario del cardi&#243;logo&#58; el dermat&#243;logo puede considerar disminuir la dosis o cambiar la hora de ingesta del medicamento antihipertensivo anterior si el paciente desarrolla mareos&#46; <span class="elsevierStyleSup">b</span> Contraindicaciones seg&#250;n la monograf&#237;a del producto minoxidil&#46; <span class="elsevierStyleSup">c</span> Comentario del cardi&#243;logo&#58; El MODB podr&#237;a utilizarse despu&#233;s de un infarto de miocardio s&#243;lo una vez que se haya alcanzado un estado estable despu&#233;s del infarto &#40;12 meses despu&#233;s&#41;&#46; No usar si se trata de angina no revascularizada&#47;evento isqu&#233;mico&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:3 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">ECA&#58; enzima convertidora de angiotensina&#59; EA&#58; efectos adversos&#59; BRA&#58; antagonistas de los receptores de la angiotensina II&#59; MODB&#58; minoxidil oral en dosis bajas&#59; El valor de p se considera estad&#237;sticamente significativo si &#60;0&#44;05 &#40;negrita&#41;&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">N</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Requiere ajuste de dosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Valor de p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Requiere la interrupci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">Valor de p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Total</span><a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;382 &#40;3&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;382 &#40;1&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;367&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">277 &#40;72&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#47;277&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;277&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hombre&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">105 &#40;27&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;105&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad&#44; media &#40;rango&#41;&#44; a&#241;os</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56&#46;9 &#40;19&#8211;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#46;79 years &#40;45&#8211;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#46;33 years &#40;49&#8211;70&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Minoxidil &#40;MODB&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dosis&#44; media &#40;rango&#41;&#44; mg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;59 &#40;0&#46;2&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;46<span class="elsevierStyleHsp" style=""></span>mg &#40;0&#46;42&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;29<span class="elsevierStyleHsp" style=""></span>mg &#40;0&#46;5&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Duraci&#243;n&#44; media &#40;rango&#41;&#44; meses&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;9 &#40;1&#8211;51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;7 &#40;1&#8211;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5 &#40;1&#8211;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span> MODB en combinaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">353 &#40;92&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#47;353&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;353&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span> MODB en monoterapia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">187 &#40;49&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#47;187&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;187&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Efectos Adversos &#40;EA&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#40;21&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#62;1 EA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;1&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;024</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertricosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">61 &#40;15&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;003</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;61<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;651&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ca&#237;da intensa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">EA Sist&#233;micos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#40;6&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#47;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mareo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;3&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Retenci&#243;n de l&#237;quidos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;2&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;315&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;009</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Malestar general&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;106&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;004</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;3<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;047</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">F&#225;rmaco antihipertensivo&#44; n&#250;mero medio &#40;rango&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;45 &#40;0&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;79 &#40;1&#8211;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;83 &#40;1&#8211;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>0 f&#225;rmacos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;1&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>1 farmaco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">225 &#40;58&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#47;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#47;225&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>2 farmacos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">125 &#40;32&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;125&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>3 o m&#225;s farmacos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;7&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;012</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ARBs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">190 &#40;49&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;190&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#47;190&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tiazidas&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">109 &#40;28&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#47;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;109&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Betabloqueantes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107 &#40;28&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#47;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;06&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;107&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Inbidores ECA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75 &#40;19&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bloqueadores de canales de Ca&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;16&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Espironolactona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#40;6&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidralazina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;1&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#47;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Doxazosina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;0&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;006</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">&#60;0&#46;001</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3424681.png"
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tblfn0005"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">La suma de los porcentajes de cada efecto adverso y tipo de f&#225;rmacos antihipertensivos puede no ser del 100&#37; porque algunos pacientes desarrollaron m&#225;s de 1 efecto adverso o fueron tratados con m&#225;s de 1 f&#225;rmaco&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tblfn0010"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Un paciente requiri&#243; suspender el tratamiento debido a una taquicardia&#46; El MODB se reinici&#243; con buena tolerancia&#44; pero se suspendi&#243; nuevamente despu&#233;s de 1 a&#241;o debido a la hipertricosis&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de la cohorte de pacientes con hipertensi&#243;n tratados con minoxidil oral a dosis bajas &#40;MODB&#41; y de los subgrupos que requirieron ajuste de dosis y suspensi&#243;n de MODB</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Estudio actual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2021&#44; Va&#241;o-Galvan et al&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dosis&#44; n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2469&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad&#44; media</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">56&#46;9 a&#241;os</span> &#40;19&#8211;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 a&#241;os &#40;8&#8211;86&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dosis de MODB&#44; media</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;59<span class="elsevierStyleHsp" style=""></span>mg &#40;0&#46;2&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;63<span class="elsevierStyleHsp" style=""></span>mg &#40;0&#46;03&#8211;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Efectos Adversos</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertricosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EA sist&#233;micos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">6&#46;8&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mareo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">3&#46;1&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Retenci&#243;n de l&#237;quidos &#40;periorbital o tobillos&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">2&#46;6&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Taquicardia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Malestar general&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cefalea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;4&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>M&#225;s de 1 EA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">1&#46;9&#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;9&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Suspensi&#243;n de MODB</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertricosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;5&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ca&#237;da de pelo intensa&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;08&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EA sist&#233;micos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;3&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3424680.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n de la frecuencia de los efectos adversos y de la interrupci&#243;n de las dosis bajas de minoxidil oral &#40;MODB&#41; encontrados en pacientes hipertensos &#40;estudio actual&#41; y en poblaci&#243;n general &#40;estudio de Va&#241;o-Galv&#225;n&#41;</p>"
        ]
      ]
      4 => array:5 [
        "identificador" => "fig0015"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 840
            "Ancho" => 1333
            "Tamanyo" => 152060
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Referencias"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Loniten &#40;Minoxidil Tablets USP&#41;&#46; Kirkland&#44; Quebeq&#58; Pharmacia &#38; Upjohn Company LLC&#44; Pfizer Canada Inc&#59; 2013&#46; Published online 2013&#46;"
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral minoxidil treatment for hair loss&#58; A review of efficacy and safety"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Randolph"
                            1 => "A&#46; Tosti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.06.1009"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46; Published online July 1"
                        "fecha" => "2020"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of low-dose oral minoxidil treatment for hair loss&#46; A systematic review and pooled-analysis of individual patient data"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jimenez-Cauhe"
                            1 => "D&#46; Saceda-Corralo"
                            2 => "R&#46; Rodrigues-Barata"
                            3 => "O&#46; Morreno-Arrones"
                            4 => "D&#46; Ortega-Quijano"
                            5 => "D&#46; Fernandez-Nieto"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/dth.14106"
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Ther&#46;"
                        "fecha" => "2020"
                        "volumen" => "33"
                        "paginaInicial" => "e14106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32757405"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety of low-dose oral minoxidil for hair loss&#58; A multicenter study of 1404 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Va&#241;&#243;-Galv&#225;n"
                            1 => "R&#46; Pirmez"
                            2 => "A&#46; Hermosa-Gelbard"
                            3 => "O&#46; Morreno-Arrones"
                            4 => "D&#46; Saceda-Corralo"
                            5 => "R&#46; Rodrigues-Barata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2021.02.054"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "1644"
                        "paginaFinal" => "1651"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33639244"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterization and management of hypertrichosis induced by low-dose oral minoxidil in the treatment of hair loss"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jimenez-Cauhe"
                            1 => "D&#46; Saceda-Corralo"
                            2 => "R&#46; Rodrigues-Barata"
                            3 => "A&#46; Hermosa-Gelbard"
                            4 => "O&#46; Morreno-Arrones"
                            5 => "R&#46; Gil-Redondo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.08.124"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "222"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32926970"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adverse effects of low-dose oral minoxidil for androgenetic alopecia in 435 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Sanabria"
                            1 => "T&#46; Vanzela"
                            2 => "N&#46; de"
                            3 => "H&#46;A&#46; Miot"
                            4 => "P&#46; Mu&#776;ller Ramos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2020.11.035"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2021"
                        "volumen" => "84"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33253848"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective cardiovascular evaluation with 24-hour Holter and 24-hour ambulatory blood pressure monitoring in men using 5-mg oral minoxidil for androgenetic alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;D&#46; Sanabria"
                            1 => "E&#46; Palmegiani"
                            2 => "A&#46;F&#46; Seron"
                            3 => "Y&#46;C&#46; Perdomo"
                            4 => "H&#46;A&#46; Miot"
                            5 => "P&#46; Mu&#776;ller Ramos"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.05.026"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46; Published online May 18"
                        "fecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Serious Adverse effects From Compounding Errors With Low-Dose Oral Minoxidil for Alopecia Treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46;M&#46; Moreno-Arrones"
                            1 => "R&#46; Rodrigues-Barata"
                            2 => "C&#46; Morales"
                            3 => "A&#46; Imbernon-Moya"
                            4 => "D&#46; Saceda-Corralo"
                            5 => "A&#46; Matji"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ad.2021.03.004"
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifiliogr&#46;"
                        "fecha" => "2022"
                        "volumen" => "113"
                        "paginaInicial" => "T725"
                        "paginaFinal" => "T727"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low-dose oral minoxidil for treatment of androgenetic alopecia and telogen effluvium in a pediatric population&#58; A descriptive study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Nicolas-Ruanes"
                            1 => "O&#46;M&#46; Moreno-Arrones"
                            2 => "D&#46; Saceda-Corralo"
                            3 => "A&#46; Hermosa-Gelbard"
                            4 => "R&#46; Rodrigues-Barata"
                            5 => "R&#46; Gil-Redondo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.04.030"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and tolerability of low-dose oral minoxidil in adolescents&#58; A retrospective review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46;M&#46; John"
                            1 => "R&#46; Sinclair"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.06.1195"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Perfil de seguridad y efectos adversos de minoxidil oral a dosis bajas en los pacientes mayores de 60 an&#771;os"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46; Vega-Diez"
                            1 => "M&#46; Gonzalez-Can&#771;ete"
                            2 => "A&#46; Rodriguez-Villa Lario"
                            3 => "A&#46; G&#243;mez-Zubiaur"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Poster presentation at AEDV Annual Congress&#46;"
                        "fecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019&#58; a pooled analysis of 1201 population-representative studies with 104 million participants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "NCD Risk Factor Collaboration &#40;NCD-RisC&#41;"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(21)01330-1"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet&#46;"
                        "fecha" => "2021"
                        "volumen" => "398"
                        "paginaInicial" => "957"
                        "paginaFinal" => "980"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34450083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Kim J&#44; Nguyen H&#46; Doxazosin&#46; In&#58; StatPearls&#46; StatPearls Publishing&#59; 2022&#46; Accessed July 24&#44; 2022&#46; <a target="_blank" href="http://www.ncbi.nlm.nih.gov/books/NBK557459/">http&#58;&#47;&#47;www&#46;ncbi&#46;nlm&#46;nih&#46;gov&#47;books&#47;NBK557459&#47;</a>&#46;"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Before-after study with 24- hour ambulatory blood pressure monitoring after the first dose of 5<span class="elsevierStyleHsp" style=""></span>mg oral minoxidil"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Jimenez-Cauhe"
                            1 => "D&#46; Saceda-Corralo"
                            2 => "A&#46; Hermosa-Gelbard"
                            3 => "O&#46; Morreno-Arrones"
                            4 => "C&#46; Pindado-Ortega"
                            5 => "E&#46; Berna-Rico"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2022.06.1205"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46;"
                        "fecha" => "2022"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and Safety of Oral Minoxidil 5<span class="elsevierStyleHsp" style=""></span>mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia&#58; An Open-Label and Global Photographic Assessment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Panchaprateep"
                            1 => "S&#46; Lueangarun"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s13555-020-00448-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Dermatol Ther &#40;Heidelb&#41;&#46;"
                        "fecha" => "2020"
                        "volumen" => "10"
                        "paginaInicial" => "1345"
                        "paginaFinal" => "1357"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32970299"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minoxidil 1<span class="elsevierStyleHsp" style=""></span>mg Orally versus Minoxidil 5&#37; Solution Topically for the Treatment of Female Pattern Hair Loss&#58; A Randomized Clinical Trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;M&#46; Ramos"
                            1 => "R&#46;D&#46; Sinclair"
                            2 => "M&#46; Kasprzak"
                            3 => "H&#46;A&#46; Miot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2019.08.060"
                      "Revista" => array:2 [
                        "tituloSerie" => "J Am Acad Dermatol&#46; Published online August 29"
                        "fecha" => "2019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of male and female pattern hair loss with sublingual minoxidil&#58; a retrospective case-series of 64 patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Sinclair"
                            1 => "L&#46; Trindade de Carvalho"
                            2 => "F&#46; Ferial Ismail"
                            3 => "N&#46; Meah"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.16616"
                      "Revista" => array:5 [
                        "tituloSerie" => "J EurAcad Dermatol Venereol&#46;"
                        "fecha" => "2020"
                        "volumen" => "34"
                        "paginaInicial" => "e795"
                        "paginaFinal" => "e796"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pharmacokinetics of 2&#46;5- to 10- mg oral doses of minoxidil in healthy volunteers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "J&#46;C&#46; Fleishaker"
                            1 => "N&#46;A&#46; Andreadis"
                            2 => "I&#46;R&#46; Welshman"
                            3 => "C&#46;E&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/j.1552-4604.1989.tb7.x0330"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol&#46;"
                        "fecha" => "1989"
                        "volumen" => "29"
                        "paginaInicial" => "162"
                        "paginaFinal" => "167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2715373"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "KazuomiKario&#46; Central Sympathetic Agents and Direct Vasodilators&#44; Editor&#40;s&#41;&#58; George L&#46; Bakris&#44; Matthew J&#46; Sorrentino&#44; Hypertension&#58; A Companion to Braunwald&#39;s Heart Disease &#40;Third Edition&#41;&#44; Elsevier&#44; 2018&#44; Pages 254-260&#44; ISBN 9780323429733&#44; doi&#46;org&#47;10&#46;1016&#47;B978-0-323-42973-3&#46;00026-3&#46;"
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minoxidil for severe hypertension after failure of other hypotensive drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;L&#46; Devine"
                            1 => "R&#46; Fife"
                            2 => "P&#46;M&#46; Trust"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.2.6191.667-c"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br Med J&#46;"
                        "fecha" => "1977"
                        "volumen" => "2"
                        "paginaInicial" => "667"
                        "paginaFinal" => "669"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/583030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023008670/v1_202401030514/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6163"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000001/v1_202401030514/S0001731023008670/v1_202401030514/es/main.pdf?idApp=UINPBA000044&text.app=https://www.actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023008670?idApp=UINPBA000044"
]