Journal Information
Vol. 98. Issue 4.
Pages 276-278 (May 2007)
Vol. 98. Issue 4.
Pages 276-278 (May 2007)
Case reports
Full text access
Primary Cutaneous Aspergillosis in a Leukemic Child
Aspergilosis Cutánea Primaria en un Niño Con Leucemia
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A. Torreloa,??
Corresponding author
atorrelo@aedv.es

Correspondence: Servicio de Dermatología, Hospital del Niño Jesús, Avda. Menéndez Pelayo, 65, 28009 Madrid, Spain.
, A. Hernández-Martína, C. Scaglioneb, L. Maderob, I. Colmeneroc, A. Zambranoa
a Departments of Dermatología, Hospital del Niño Jesús, Madrid, Spain
b Departments of Oncología, Hospital del Niño Jesús, Madrid, Spain
c Departments of Anatomía Patológica, Hospital del Niño Jesús, Madrid, Spain
Article information
Abstract

Primary cutaneous aspergillosis is a rare cutaneous disease that usually affects immunodepressed patients of any age. The most common associated disorders in children are leukemias and lymphomas although it can also occur in neonates and preterms due to their intrinsic immunological immaturity. We report the case of a 4-year-old boy diagnosed of acute lymphoblastic leukemia that, during chemotherapy, developed an ulceronecrotic inflammatory cutaneous lesion in the venopuncture area of the left forearm, and whose microbiological culture was positive for Aspergillus flavus.

Key words:
primary cutaneous aspergillosis
inmunodepression
leukemia
Resumen

La aspergilosis cutánea primaria es una enfermedad cutánea infrecuente que suele presentarse en individuos inmunodeprimidos de cualquier edad. En los niños, las patologías asociadas con mayor frecuencia son las leucemias y los linfomas, aunque también puede ocurrir en neonatos y prematuros debido a su inmadurez inmunológica intrínseca. Presentamos el caso de un varón de 4 años diagnosticado de leucemia linfoblástica aguda que durante el tratamiento quimioterápico presentó una lesión cutánea inflamatoria ulceronecrótica en la zona de venopunción del antebrazo izquierdo, y cuyo cultivo microbiológico fue positivo para Aspergillus flavus.

Palabras clave:
aspergilosis cutánea primaria
inmunodepresión
leucemia
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References
[1.]
R. Galimberti, A. Kowalczuk, I. Hidalgo Parra, M. González Ramos, V. Flores.
Cutaneous aspergillosis: a report of six cases.
Br J Dermatol, 139 (1998), pp. 522-526
[2.]
C.M. Mowad, T.V. Nguyen, C. Jaworsky, P.J. Honig.
Primary cutaneous aspergillosis in an immunocompetent child.
J Am Acad Dermatol, 33 (1995), pp. 136-137
[3.]
C. Ajith, S. Dogra, B. Radotra, A. Chakrabarti, B. Kumar.
Primary cutaneous aspergillosis in an immunocompetent individual.
J Eur Acad Dermatol Venereol, 20 (2006), pp. 738-739
[4.]
D. D’Antonio, L. Pagano, C. Girmenia, G. Parruti, L. Mele, A. Candoni, et al.
Cutaneous aspergillosis in patients with haematological malignancies.
Eur J Clin Microbiol Infect Dis, 19 (2000), pp. 362-365
[5.]
L.S. Romero, S.J. Hunt.
Hickman catheter-associated primary cutaneous aspergillosis in a patient with the acquired immunodeficiency syndrome.
Int J Dermatol, 34 (1995), pp. 551-553
[6.]
S.L. Gerson, G.H. Talbot, S. Hurwitz, B.L. Strom, E.J. Lusk, P.A. Cassileth.
Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia.
Ann Intern Med, 100 (1984), pp. 345-351
[7.]
G.J. Murakawa, J.D. Harvell, P. Lubitz, S. Schnoll, S. Lee, T. Berger.
Cutaneous aspergillosis and acquired immunodeficiency syndrome.
Arch Dermatol, 136 (2000), pp. 365-369
[8.]
M.E. Grossman, E.C. Fithian, C. Behrens, J. Bissinger, M. Fracaro, H.C. Neu.
Primary cutaneous aspergillosis in six leukemic children.
J Am Acad Dermatol, 12 (1985), pp. 313-318
[9.]
K.A. Richards, A.J. Mancini.
A painful erythematous forearm nodule in a girl with Hodgkin disease. Diagnosis: primary cutaneous aspergillosis.
Arch Dermatol, 136 (2000), pp. 1165-1170
[10.]
J.G. Roth, J.L. Troy, N.B. Esterly.
Multiple cutaneous ulcers in a premature neonate.
Pediatr Dermatol, 8 (1991), pp. 253-255
[11.]
C.A. Woodruff, A.A. Hebert.
Neonatal primary cutaneous aspergillosis: case report and review of the literature.
Pediatr Dermatol, 19 (2002), pp. 439-444
[12.]
J.L. Rowen, A.G. Correa, D.M. Sokol, H.K. Hawkins, M.L. Levy, M.S. Edwards.
Invasive aspergillosis in neonates: report of five cases and literature review.
Pediatr Infect Dis J, 11 (1992), pp. 576-582
[13.]
S.J. Hunt, C. Nagi, K.G. Gross, D.S. Wong, W.C. Mathews.
Primary cutaneous aspergillosis near central venous catheters in patients with the acquired immunodeficiency syndrome.
Arch Dermatol, 128 (1992), pp. 1229-1232
[14.]
M. Aoun, P. Van der Auwera, J. Gerain, J. Klastersky.
Aspergillosis in the immunocompromised: focus on treatment.
Recent Results Cancer Res, 132 (1993), pp. 127-136
[15.]
P. García-Martos, L. García-Agudo, J. Gutiérrez-Calzada, J. Ruiz-Aragón, A. Saldarreaga, P. Marín.
Actividad in vitro de anfotericina B, itraconazol y voriconazol frente a 20 especies de Aspergillus empleando el método de microdilución Sensititre.
Enferm Infecc Microbiol Clin, 23 (2005), pp. 15-18
[16.]
T. Wieland, A. Liebold, M. Jagiello, G. Retzl, D.E. Birnbaum.
Superiority of voriconazole over amphotericin B in the treatment of invasive aspergillosis after heart transplantation.
J Heart Lung Transplant, 24 (2005), pp. 102-104
[17.]
F. Schuster, C. Moelter, I. Schmid, U.B. Graubner, B. Kammer, B.H. Belohradsky, et al.
Successful antifungal combination therapy with voriconazole and caspofungin.
Pediatr Blood Cancer, 44 (2005), pp. 682-685
[18.]
N. Auffret, F. Janssen, P. Chevalier, R. Guillemain, C. Amrein, C. Le Beller.
Voriconazole photosensitivity: 7 cases.
Ann Dermatol Venereol, 133 (2006), pp. 330-332
Copyright © 2007. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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