Journal Information
Vol. 100. Issue 7.
Pages 606-610 (September 2009)
Share
Share
Download PDF
More article options
Vol. 100. Issue 7.
Pages 606-610 (September 2009)
Case report
Full text access
Post-Traumatic Basal Cell Carcinoma Associated With Patch Testing
Carcinoma Basocelular Postraumático Relacionado con Pruebas Epicutáneas
Visits
5862
M.T. Bordel-Gómeza,
Corresponding author
maitebordel@aedv.es
matebordel@yahoo.es

Correspondence: C/ Martínez Villergas n.° 6, 1.° B, 49003 Zamora, Spain.
, A. Miranda-Romerob
a Servicio de Dermatología, Complejo Asistencial Virgen de la Concha, Zamora, Spain
b Servicio de Dermatología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain
This item has received
Article information
Abstract

Basal cell carcinoma is the most common epithelial skin cancer in humans and usually effects elderly individuals. Although the pathogenesis is directly related to exposure to ultraviolet sunlight, other factors, particularly trauma, may be involved. We present the case of a woman with contact dermatitis due to sensitization to metals. She developed superficial basal cell carcinoma at the same site as a patch test—performed 30 months earlier—that was strongly positive to 1% gold chloride. In the histologic study with a scanning electron microscope, we detected electron-dense particles in the dermis which were subsequently identified as gold.

Key words:
skin cancer
post-traumatic basal cell carcinoma
contact dermatitis
patch test
Resumen

El carcinoma basocelular (CBC) es la neoplasia cutánea epitelial más frecuente de la raza humana, que afecta generalmente a personas de edad avanzada. Aunque su patogénesis está directamente relacionada con la exposición a las radiaciones ultravioletas solares, también pueden involucrarse otros factores, entre los que destacamos los traumatismos. Aportamos el caso de una mujer con dermatitis de contacto por sensibilización a metales, que desarrolló un CBC superficial en la misma localización en la que tuvo una prueba epicutánea fuertemente positiva al cloruro de oro 1%, realizada 30 meses antes del desarrollo del tumor. Realizamos un estudio del corte histológico con el microscopio electrónico de barrido, que nos demostró la presencia de partículas electrón-densas en la dermis, que fueron identificadas definitivamente como oro.

Palabras clave:
neoplasia cutánea
carcinoma basocelular postraumático
dermatitis de contacto
pruebas epicutáneas
Full text is only aviable in PDF
References
[1.]
D.L. Miller, M.A. Weinstock.
Nonmelanoma skin cancer in the United States: incidence.
J Am Acad Dermatol, 30 (1994), pp. 774-778
[2.]
F. Festa, R. Kumar, S. Sanyal, B. Unden, L. Nordfors, B. Lindholm, et al.
Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism.
Mutat Res, 574 (2005), pp. 105-111
[3.]
R.P. Gallagher, B. Ma, D.I. McLean, C.P. Yang, V. Ho, J.A. Carruthers, et al.
Trends in basal cell carcinoma, squamous cell carcinoma, and melanoma of the skin from 1973 through 1987.
J Am Acad Dermatol, 23 (1990), pp. 413-421
[4.]
H. Von Domarus, P.J. Steven.
Metastatic basal cell carcinoma; report of five cases and review of 170 cases in the literature.
J Am Acad Dermatol, 10 (1984), pp. 1043-1060
[5.]
A.J. Cox, W.M. Kenneth.
Gold in the dermis following gold therapy for rheumatoid arthritis.
Arch Dermatol, 108 (1973), pp. 655-657
[6.]
C.E. Keen, K. Brady, N. Kirkham, D.A. Levison.
Gold in the dermis following chrysotherapy: histopathology and microanalysis.
Histopathology, 23 (1993), pp. 355-360
[7.]
A.W. Kopf.
Computer analysis of 3531 basal-cell carcinomas of the skin.
J Dermatol, 6 (1979), pp. 267-281
[8.]
M.R. Hussein.
Ultraviolet radiation and skin cancer: molecular mechanisms.
J Cutan Pathol, 32 (2005), pp. 191-205
[9.]
M.H. Rustin, T.J. Chambers, D.D. Munro.
Post-traumatic basal cell carcinomas.
Clin Exp Dermatol, 9 (1984), pp. 379-383
[10.]
J.K. Wilkin, D. Strobel.
Basal cell carcinoma arising at the site of venipuncture.
Cutis, 36 (1985), pp. 297-298
[11.]
A.J. Orfuss.
Lupus vulgaris and superimposed basal cell epitheliomas.
Arch Dermatol, 103 (1971), pp. 555
[12.]
J.D. Rich, B.F. Shesol, D.W. Horne 3rd.
Basal cell carcinoma arising in a smallpox vaccination site.
J Clin Pathol, 33 (1980), pp. 134-135
[13.]
I. Kantor, B.W. Berger, J.M. Wilentz.
Basal cell epithelioma in a thermal burn scar.
J Occup Med, 12 (1970), pp. 170-172
[14.]
J. Ewing.
Modern attitude toward traumatic cancer.
Arch Pathol, 19 (1935), pp. 690-728
[15.]
H.L. Stoll Jr, J.T. Crissey.
Epithelioma from single trauma.
N Y State J Med, 62 (1962), pp. 496-500
[16.]
I. Ozyazgan, O. Kontas.
Previous injuries or scars as risk factors for the development of basal cell carcinoma.
Scand J Plast Reconstr Hand Surg, 38 (2004), pp. 11-15
Copyright © 2009. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
Idiomas
Actas Dermo-Sifiliográficas
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?